| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9921095 | European Journal of Pharmacology | 2005 | 10 Pages |
Abstract
In conclusion, PDE5 is present in human and guinea pig cerebral arteries, and is inhibited by sildenafil at micromolar levels. Sildenafil in vitro is a poor dilator of guinea pig cerebral arteries unless a nitric oxide donor is co-administered, corresponding to the previous findings in vivo.
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Authors
Christina Kruuse, Tejvir S. Khurana, Sergei D. Rybalkin, Steffen Birk, Ulla Engel, Lars Edvinsson, Jes Olesen,