Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9921116 | European Journal of Pharmacology | 2005 | 5 Pages |
Abstract
We have recently reported that coadministration of sulpiride, an antipsychotic drug, and fluvoxamine, a selective serotonin (5-HT) reuptake inhibitor, selectively increases in vivo dopamine release in the prefrontal cortex. This study examined the effects of coadministration of these drugs on duration of immobility in the tail suspension test using mice. Neither sulpiride (3 or 10 mg/kg) nor fluvoxamine (10 or 20 mg/kg) alone affected immobility time, whereas coadministration significantly reduced immobility time. WAY100635, a 5-HT1A receptor antagonist, did not affect the effects of sulpiride and fluvoxamine coadministration, but reduced immobility time in combination with fluvoxamine (20 mg/kg). A high dose of fluvoxamine alone (60 mg/kg) also reduced immobility time. These results suggest that the antidepressant-like effects of fluvoxamine in combination with sulpiride or WAY100635 in the tail suspension test are mediated by the activation of dopamine or 5-HT systems, respectively.
Related Topics
Life Sciences
Neuroscience
Cellular and Molecular Neuroscience
Authors
Yukio Ago, Toshiya Harasawa, Soichi Itoh, Shigeo Nakamura, Akemichi Baba, Toshio Matsuda,