Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9921159 | European Journal of Pharmacology | 2005 | 5 Pages |
Abstract
The local peripheral (subcutaneous) injection of phosphodiesterase 3 inhibitor trequinsin dose-dependently enhanced formalin-evoked flinching during late second phase of this test. Treatment with the nitric oxide synthase inhibitor N-L-nitro-arginine methyl ester or guanylyl cyclase inhibitor 1-H-[1,2,4,]oxadiazolo[4,3-a]quinoxalin-1-one significantly reversed trequinsin-induced pronociceptive effect. Results suggest that the peripheral phosphodiesterase 3 may play an important physiologic role on inflammatory pain by controlling cyclic AMP levels and therefore the nociceptor threshold.
Related Topics
Life Sciences
Neuroscience
Cellular and Molecular Neuroscience
Authors
Jorge E. Torres-López, Vinicio Granados-Soto,