Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9921353 | European Journal of Pharmacology | 2005 | 12 Pages |
Abstract
Dextromethorphan (5-40 mg/kg, s.c.), mecamylamine (0.25-4 mg/kg, i.p.) and bupropion (10-30 mg/kg, i.p.) alone produced variable effects on signs of withdrawal. However, two low-dose combinations, i.e., dextromethorphan (5 mg/kg, s.c.) and mecamylamine (0.25 mg/kg, i.p.), mecamylamine (0.25 mg/kg, i.p.) and bupropion (10 mg/kg, i.p.) as well as the three-drug combination significantly attenuated diarrhea and weight loss; none of the agents administered alone had these effects. The results of the present study provide evidence that α3β4 nicotinic receptors are involved in the expression of at least two signs of opioid withdrawal.
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Authors
Olga D. Taraschenko, Vishal Panchal, Isabelle M. Maisonneuve, Stanley D. Glick,