Ethanol Withdrawal-Associated Allodynia and Hyperalgesia: Age-Dependent Regulation by Protein Kinase Cϵ and γ Ιsozymes

This study examines age-specific nociceptive responses after ethanol exposure by using 2 different ages of rats. The results suggest that ethanol age-dependently alters sensitivity to mechanical and thermal stimuli via specific protein kinase C isozymes. These results begin to ascertain the mechanisms that produce abnormal pain after alcohol exposure.