Inhibition of chemical and low-intensity mechanical nociception by activation of histamine H3 receptors

Certain classes of pain-transmitting fibers possess histamine H3 receptors, but the localization and functional significance of these inhibitory receptors was not known. The present study shows that drugs that stimulate H3 receptors can reduce behavioral responses produced by some, but not all, painful stimuli. Thus, H3 agonists could be a new type of therapy for certain kinds of pain disorders.