| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9932008 | The Journal of Pain | 2005 | 9 Pages |
Abstract
Chronic pain diminishes the quality of life. Here, we show that the immediate early gene Egr1 plays a role in chronic inflammatory, but not acute, pain. Egr1 knockout mice showed reduced nociceptive behaviors to persistent inflammatory pain and inflammation increased Egr1 expression in the anterior cingulate cortex of wild-type mice.
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Authors
Shanelle W. Ko, Kunjumon I. Vadakkan, Hushan Ao, Amelia Gallitano-Mendel, Feng Wei, Jeffrey Milbrandt, Min Zhuo,