Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9933544 | International Journal of Developmental Neuroscience | 2005 | 14 Pages |
Abstract
There are three main findings in this study. First, changes in the distribution and amount of cell death correlate well with measured PARP-1 levels after hypoxia-ischemia, and both display biphasic characteristics. Second, there are significant early, transient morphological and biochemical changes in the contralateral cortex after neonatal hypoxia-ischemia due to unilateral permanent occlusion of a carotid artery followed by 2Â h of systemic hypoxia. Third, variability in the responses of individual pups to hypoxia-ischemia suggests the presence of unidentified confounding factors.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Developmental Biology
Authors
Shannon S. Martin, J. Regino Perez-Polo, Kristin M. Noppens, Marjorie R. Grafe,