Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9933583 | International Journal of Developmental Neuroscience | 2005 | 7 Pages |
Abstract
Because our previous work showed that intermittent hypoxia alters neuronal excitability and Na+ current density, we examined in this work the effect of intermittent hypoxia on Na+ channel subtypes using 3H-saxitoxin (3H-STX) autoradiography and immunoblotting. Mice were exposed to intermittent hypoxia for 2 or 4 weeks from postnatal day 2 or 3. A 2-week intermittent hypoxia reduced cerebral STX binding density with significant decrease in Nav1.2 in the rostral and Nav1.1 in the caudal regions. In contrast, a 4-week intermittent hypoxia tended to increase STX binding density in most brain regions. Our data suggest that intermittent hypoxia differentially regulates plasma membrane Na+ channels in the developing brain, depending on duration of intermittent hypoxia.
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Authors
Peng Zhao, Jin Xue, Xiang-Qun Gu, Gabriel G. Haddad, Ying Xia,