| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9945112 | The Annals of Thoracic Surgery | 2005 | 9 Pages |
Abstract
The DNA damage assayed by 8-oxoG was significantly increased in statically preserved versus continuously perfused hearts. The DNA repair enzymes MYH, OGG1, and MSH2 were also markedly decreased in the static preservation versus continuous hypothermic perfusion groups. Continuous hypothermic perfusion reduces oxidative damage and extends preservation without compromising function.
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Authors
Torin P. MD, Christopher J. MD, Pramod N. MD, MS, Chiming MD, PhD, Fred PhD, Rene PhD, John V. MD,