| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9945811 | The Annals of Thoracic Surgery | 2005 | 7 Pages |
Abstract
Hypoxia-reoxygenation induces ERK 1/2 phosphorylation, as well as transactivation of the transcription factors NFκB and EGR-1 in PAEC. Cyclosporine selectively reduces proinflammatory mediator secretion, likely by transcriptional regulation through NFκB and EGR-1. This is the first demonstration of ERK 1/2 inhibition afforded by CSA.
Keywords
EMSATNFPAECJnkMCPNFATEGRERK 1/2MWMTACc-Jun N-terminal kinaseMAPKNFκBLIRIElectrophoretic mobility shift assayenzyme linked immunosorbent assayCSAischemia-reperfusioninterleukinTacrolimusELISAstandard error of meanPulmonary artery endothelial cellsCyclosporineextracellular signal regulated kinaselung ischemia-reperfusion injuryNuclear Factor of Activated T Cellstumor necrosis factornuclear factor kappa BAlveolar macrophageSEMHypoxia and reoxygenationearly growth responsemonocyte chemoattractant proteinmitogen activated protein kinaseCINC
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Authors
Alexander S. MD, Brendan C. BS, Andrew D. Pharm D, Anton S. MBChB, Michael S. MD,