| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9951494 | Thrombosis Research | 2018 | 9 Pages |
Abstract
While arachidonic acid induces platelet activation at low concentrations and during short incubation time, higher concentrations and lasting incubation evokes adenylate cyclase activation and subsequent protein phosphorylation corresponding to reduced platelet activation, but also enhanced pro-coagulant activity and reduced viability. Our observations provide further proof for the complex fine tuning of platelet responses in a time and agonist concentration dependent manner.
Keywords
VASPCOXCalDAG-GEFITxA2FITCSGCPKGFSCPrPIP3SSCPGD2pKaPDEPGE2inositol 1,4,5 trisphosphateROScyclooxygenaseacetoxymethylArachidonic acidLOXThromboxane A2diacylglycerolDAGSoluble guanylate cyclasephycoerythrinPhosphatidylserinePhosphodiesteraseProtein phosphorylationVasodilator-stimulated phosphoproteinfluorescein isothiocyanatelipoxygenasesodium nitroprussideNitric oxideVasodilator stimulated phosphoproteinforward scatterside scattercAMP-dependent protein kinasecAMP dependent protein kinasecGMP-dependent protein kinaseProstaglandin D2Prostaglandin E2Platelet rich plasmaBlood plateletswashed plateletsSNPstimulatory G-proteinReactive oxygen speciesthromboxane receptor
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
Natalia Rukoyatkina, Valentina Shpakova, Michael Panteleev, Alexandra Kharazova, Stepan Gambaryan, Joerg Geiger,