| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9951957 | Psychiatry Research: Neuroimaging | 2018 | 15 Pages |
Abstract
Connectivity features based on resting-state (RS) functional magnetic resonance imaging (fMRI) demonstrate great promise as biomarkers to guide diagnosis and treatment in major depressive disorder (MDD). However, there is a pressing need for valid, reliable biomarkers closer to the bedside for clinical research and practice. This study directly compared RS-fMRI connectivity features with transcranial magnetic stimulation (TMS) neurophysiological measures, long interval cortical inhibition (LICI) and cortical silent period (CSP), in female adolescents with MDD. LICI-200 showed the most significant associations with RS functional connectivity features, demonstrating its potential to evaluate the neurochemical underpinnings of network features in MDD.
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Authors
Irena Balzekas, Charles P. Lewis, Julia Shekunov, John D. Port, Gregory A. Worrell, Hang Joon Jo, Paul E. Croarkin,