Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration

Article ID	Journal	Published Year	Pages	File Type
9954064	Redox Biology	2018	15 Pages	PDF

Keywords

IVD cyt-c PGC-1α NMN VDAC SOD2 MPTP Sirtuins AGEs Sirtuin 3 GAPDH TrxR2 SkQ1 TRX2 MMP CCK-8 MitoTEMPO AMPK EdU ROS mitochondrial permeability transition pore Intervertebral disc degeneration Thioredoxin 2 Thioredoxin reductase 2 TdT-mediated dUTP nick end labeling TUNEL Intervertebral disc Sirts Superoxide dismutase 2 cytochrome c cell counting kit-8 Advanced glycation end products nicotinamide mononucleotide Nucleus pulposus Mitochondrial membrane potential adenosine monophosphate-activated protein kinase voltage-dependent anion channel glyceraldehyde-3-phosphate dehydrogenase Reactive oxygen species Peroxisome proliferator-activated receptor-γ coactivator 1α

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Ageing

Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration

Authors

Yu Song, Shuai Li, Wen Geng, Rongjin Luo, Wei Liu, Ji Tu, Kun Wang, Liang Kang, Huipeng Yin, Xinghuo Wu, Yong Gao, Yukun Zhang, Cao Yang,