Targeting NLRP3 inflammasome via acetylsalicylic acid: Role in suppressing hepatic dysfunction and insulin resistance induced by atorvastatin in naïve versus alcoholic liver in rats

Article ID	Journal	Published Year	Pages	File Type
9954854	Biomedicine & Pharmacotherapy	2018	10 Pages	PDF

Keywords

NACHT, LRR and PYD domains-containing protein 3 RER KCS NLRP3 Bcl2 BSP IL-1β HOMA-IR HFD ALT GSSG GSH AFL Mallory-Denk bodies MDB ASA cox-I ROS UDP-glucuronosyltransferase Atorvastatin ALD AST ALK Alkaline phosphatase Homeostasis model assessment-insulin resistance acetylsalicylic acid Inflammasome Alcohol interleukin 1beta SER alcoholic liver disease aspartate transaminase Oxidative stress High fat diet rough endoplasmic reticulum smooth endoplasmic reticulum polymerase chain reaction PCR alcoholic fatty liver Glutathione glutathione disulfide Reactive oxygen species

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Targeting NLRP3 inflammasome via acetylsalicylic acid: Role in suppressing hepatic dysfunction and insulin resistance induced by atorvastatin in naïve versus alcoholic liver in rats

Authors

Omnyah A. El-Kharashi, Dalia Alaa El-Din Aly El-Waseef, Enas S. Nabih, Doaa I. Mohamed,