Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9954855 | Biomedicine & Pharmacotherapy | 2018 | 6 Pages |
Abstract
In the present study, we investigated the hypolipidemic and hepatoprotective potential of the commercially available crushed Ajwa date seed-extract on the toxicity caused by the atorvastatin in high-fat diet (HFD)-induced hyperlipidemic rats. Male albino rats were divided into two main groups, Group I (normal control) and Group II (HFD); Group II was further divided into four subgroups: Group IIa (HFD control), Group IIb (Atorvastatin: A10)-6 rats were administered with 10âmg/kg atorvastatin daily for 30 days, Group IIc (Ajwa seed extract: AJ)-6 rats were given 1000âmg/kg Ajwa seed extract daily for 30 days, Group IId (AJâ+âA10)-6 rats were given Ajwa seed extract 1000âmg/kg and Atorvastatin 10âmg/kg daily for 30 days. The data obtained suggested that Ajwa seed extract lowered the serum cholesterol level in HFD rats and demonstrated the hepatoprotective effect in combination with atorvastatin by reducing the levels of ALT and AST. In conclusion, it protected the tissues from the detrimental effects of hyperglycemia and enhanced antioxidant activity. Furthermore, the dose-limiting toxicity of atorvastatin may be reduced if the Ajwa seed extract is incorporated in the current treatment regimens to treat hyperlipidemia in hypercholesteremic individuals.
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Authors
Tariq Jamal Khan, Abudukadeer Kuerban, Syed Shoeb Razvi, Mohamed G. Mehanna, Khalid Ali Khan, Yaaser Q. Almulaiky, Hassan Mostafa Faidallah,