Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9956904 | International Journal of Cardiology | 2005 | 4 Pages |
Abstract
Previous studies have shown that endothelin-1 (ET-1) may play a pathophysiological role in myocardial ischemia/reperfusion injury. In the present study, BMS-182874 significantly improved the recovery of cardiac function and reduced the release of CK during reperfusion after ischemia and the content of tumor necrosis factor (TNF-α) in myocardial tissues. BMS-182874 also reduced myocardial injury and the increased level of TNF-α by exogenous ET-1. These results suggest that the cardioprotective effects of the ET receptor antagonist may be related to inhibition of TNF-α production.
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Authors
Tian-Lun Yang, Mei-Fang Chen, Jun-Ling Jiang, Qi-Ying Xie, Yun-Ping Li, Yuan-Jian Li,