Article ID Journal Published Year Pages File Type
9956904 International Journal of Cardiology 2005 4 Pages PDF
Abstract
Previous studies have shown that endothelin-1 (ET-1) may play a pathophysiological role in myocardial ischemia/reperfusion injury. In the present study, BMS-182874 significantly improved the recovery of cardiac function and reduced the release of CK during reperfusion after ischemia and the content of tumor necrosis factor (TNF-α) in myocardial tissues. BMS-182874 also reduced myocardial injury and the increased level of TNF-α by exogenous ET-1. These results suggest that the cardioprotective effects of the ET receptor antagonist may be related to inhibition of TNF-α production.
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Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine
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