Left Ventricular Dysfunction After Acute Intracranial Hypertension is Associated with Increased Hydroxyl Free Radical Production, Cardiac Ryanodine Hyperphosphorylation, and Troponin I Degradation

The present findings demonstrate that hemodynamic instability after intracranial hypertension is associated with oxidative stress and post-translational changes to RyR2 and TnI degradation. Despite this, the myocardial responsiveness to β1 adrenergic stimulation is preserved in rats with depressed myocardial function.