Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9974950 | The Journal of Heart and Lung Transplantation | 2005 | 12 Pages |
Abstract
Our highly sensitive method permits quantitation of many gene transcripts simultaneously in small, bronchoscopically acquired biopsy specimens of allografts. Transcript signatures obtained by this approach suggest that airway and alveolar responses to rejection differ and that endobronchial biopsy specimens assess lymphocytic bronchitis and chronic rejection but are not proxies for transbronchial biopsy specimens. Further, they reveal changes in airway expression of the specific genes involved in host defense and remodeling and suggest that the measurement of transcripts correlating with lymphocytic bronchitis may be diagnostic adjuncts to histopathology.
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Authors
Xiang MD, PhD, Jeffrey A. MD, Gregory MD, PhD, Kirk D. MD, Samantha PhD, Timothy BSc, George H. MD,