| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9974997 | The Journal of Heart and Lung Transplantation | 2005 | 4 Pages |
Abstract
Autoantibodies to prothrombin, first described almost 50 years ago, are paradoxically associated with thrombosis. Described is an unusual case of fatal hypercoagulability in a patient with multiple arterial and venous thromboembolic complications despite intense anticoagulation while being bridged to transplantation with a left ventricular assist device. Serum analysis revealed the presence of prothrombin autoantibodies and high titers of anti-nuclear antibodies, and autopsy revealed pulmonary arteriolar vasculitis. These findings suggest an autoimmune basis for the presence of anti-prothrombin antibodies and the hypercoagulable state observed in the present case.
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Authors
Yasmin MD, Perumal MD, MRCP, Reynolds MD, Paul MD, Kimberly Robertson, O.H. MD,