| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9975027 | The Journal of Heart and Lung Transplantation | 2005 | 5 Pages |
Abstract
Endogenous B-type natriuretic peptide (BNP) is thought to be produced in the cardiac ventricles. After sub-total cardiectomy and implantation of a total artificial heart (TAH), the abrupt withdrawal of BNP impairs renal function despite normal hemodynamic variables. We hypothesized that abrupt withdrawal of endogenous BNP may impair renal function and volume homeostasis and BNP may have a direct renal influence unrelated to its cardiovascular effect. Nesiritide infusion should be supplemented in the interim and weaned slowly until BNP levels normalize, which suggests that BNP is produced in tissues other than the cardiac ventricles.
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Authors
Reynolds MD, Yasmin MD, Biswajit MD, Whitson MD, Aly MD, Toni RN, Timothy J. MD, Nancy RN, O.H. MD,