Inhibition of Obliterative Airway Disease Development Following Heterotopic Murine Tracheal Transplantation by Costimulatory Molecule Blockade Using Anti-CD40 Ligand Alone or in Combination With Donor Bone Marrow

The administration of MR-1 alone in combination with infusions of donor bone marrow cells significantly attenuated the development of OAD. Tolerance-inducing regimens such as this deserve further investigation in the prevention of post-lung transplant obliterative bronchiolitis following human lung transplantation.