| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9978788 | The Journal of Thoracic and Cardiovascular Surgery | 2005 | 7 Pages |
Abstract
Induction of brain death leads to significant left ventricular dysfunction in this porcine model. Cardiac β-adrenergic receptors are clearly uncoupled after brain death, and our data suggest that the mechanism is acute increase of myocardial β-adrenergic receptor kinase activity, leading to β-adrenergic receptor desensitization and ventricular dysfunction.
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Authors
Prakash K. MD, Jefferson M. MD, Jodie Y. PhD, Kelly M. MD, Connie J. BS, Walter H. MD, Jeffrey M. MD, Shahab A. MD,