| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9996755 | Archives of Oral Biology | 2005 | 8 Pages |
Abstract
Genome sequencing and gene mapping permitted to refine the amelogenin story, in relation to the common location (chromosome 4 in human) of several genes coding for dental proteins and SPARCL1, a SPARC (osteonectin) relative. Amelogenin shares a similar organisation with these genes and a blast search in databanks indicates a strong relationship between amelogenin, ameloblastin and enamelin. Taken together these data suggest that amelogenin could have originated from either ameloblastin or enamelin, themselves being created from SPARCL1, which itself originated from a SPARC duplication, 600 millions years ago.
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Authors
Jean-Yves Sire, Sidney Delgado, Delphine Fromentin, Marc Girondot,