Adenomatoid Odontogenic Tumour of the Maxilla: Immunohistochemical Study

To define the nature of the tumour cells in adenomatoid odontogenic tumour and assess whether the tumour is a neoplastic or developmental lesion, the expression of 2 markers of the cell cycle, p16INK4A and Ki-67, and the alteration of 1 gene, the p16INK4A gene, were evaluated in a patient with adenomatoid odontogenic tumour The results showed that neither p16INK4A expression nor Ki-67 expression were detected. Based on the immunohistochemical and fluorescence in situ hybridisation results, adenomatoid odontogenic tumour is not considered to be a neoplastic growth of the odontogenic epithelium.