The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice Fulltext Access 11 Pages 2016
LRRC8A channels support TNFα-induced superoxide production by Nox1 which is required for receptor endocytosis Fulltext Access 11 Pages 2016
A novel quinone derived from 5-hydroxyindoleacetic acid reacts with protein: Possible participation of oxidation of serotonin and its metabolite in the development of atherosclerosis Fulltext Access 11 Pages 2016
PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease Fulltext Access 11 Pages 2016
Review articleMitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders Fulltext Access 11 Pages 2016
Corpus callosum microstructural changes associated with Kawashima Nintendo Brain Training in patients with multiple sclerosis Fulltext Access 11 Pages 2016
Tissue remodeling after interference RNA mediated knockdown of transthyretin in a familial amyloidotic polyneuropathy mouse model Fulltext Access 11 Pages 2016
Potential role of 8-oxoguanine DNA glycosylase 1 as a STAT1 coactivator in endotoxin-induced inflammatory response Fulltext Access 11 Pages 2016
The effects of short-term JNK inhibition on the survival and growth of aged sympathetic neurons Fulltext Access 11 Pages 2016
Preservation of cell-survival mechanisms by the presenilin-1 K239N mutation may cause its milder clinical phenotype Fulltext Access 11 Pages 2016
IDH2 deficiency impairs mitochondrial function in endothelial cells and endothelium-dependent vasomotor function Fulltext Access 11 Pages 2016
Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer's disease Fulltext Access 11 Pages 2016
Molecular basis of reactive oxygen species-induced inactivation of α4β2 nicotinic acetylcholine receptors Fulltext Access 11 Pages 2016
Imaging the accumulation and suppression of tau pathology using multiparametric MRI Fulltext Access 11 Pages 2016
Signaling in dopamine D2 receptor-oxytocin receptor heterocomplexes and its relevance for the anxiolytic effects of dopamine and oxytocin interactions in the amygdala of the rat Fulltext Access 11 Pages 2016
Propofol but not sevoflurane prevents mitochondrial dysfunction and oxidative stress by limiting HIF-1α activation in hepatic ischemia/reperfusion injury Fulltext Access 11 Pages 2016
Theory of Mind in aging: Comparing cognitive and affective components in the faux pas test Fulltext Access 11 Pages 2016
Inhibitory nitrosylation of mammalian thioredoxin reductase 1: Molecular characterization and evidence for its functional role in cellular nitroso-redox imbalance Fulltext Access 11 Pages 2016
ERβ expression in the endothelium ameliorates ischemia/reperfusion-mediated oxidative burst and vascular injury Fulltext Access 11 Pages 2016
On the use of peroxy-caged luciferin (PCL-1) probe for bioluminescent detection of inflammatory oxidants in vitro and in vivo - Identification of reaction intermediates and oxidant-specific minor products Fulltext Access 11 Pages 2016
Manganese ions enhance mitochondrial H2O2 emission from Krebs cycle oxidoreductases by inducing permeability transition Fulltext Access 11 Pages 2016
A comprehensive evaluation of the [2-14C](-)-epicatechin metabolome in rats Fulltext Access 11 Pages 2016
Regulation of mitochondrial genome replication by hypoxia: The role of DNA oxidation in D-loop region Fulltext Access 11 Pages 2016
SPAK plays a pathogenic role in IgA nephropathy through the activation of NF-κB/MAPKs signaling pathway Fulltext Access 11 Pages 2016
Abdominal paracentesis drainage protects rats against severe acute pancreatitis-associated lung injury by reducing the mobilization of intestinal XDH/XOD Fulltext Access 11 Pages 2016
Knockdown of delta-5-desaturase promotes the anti-cancer activity of dihomo-γ-linolenic acid and enhances the efficacy of chemotherapy in colon cancer cells expressing COX-2 Fulltext Access 11 Pages 2016
Reactive oxygen species facilitate the EDH response in arterioles by potentiating intracellular endothelial Ca2+ release Fulltext Access 11 Pages 2016
The tetrahydrobiopterin radical interacting with high- and low-spin heme in neuronal nitric oxide synthase - A new indicator of the extent of NOS coupling Fulltext Access 11 Pages 2016
Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIPAHA) Fulltext Access 11 Pages 2016
Heme oxygenase-1 dependant pathway contributes to protection by tetramethylpyrazine against chronic hypoxic injury on medulla oblongata in rats Fulltext Access 11 Pages 2016
Modification of platelet proteins by 4-hydroxynonenal: Potential Mechanisms for inhibition of aggregation and metabolism Fulltext Access 11 Pages 2016
Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays Fulltext Access 11 Pages 2016
Glial influences on BBB functions and molecular players in immune cell trafficking Fulltext Access 11 Pages 2016
Identification of melanoma cells and lymphocyte subpopulations in lymph node metastases by FTIR imaging histopathology Fulltext Access 11 Pages 2016
S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation Fulltext Access 11 Pages 2016
Hepatic carboxylesterase 3 (Ces3/Tgh) is downregulated in the early stages of liver cancer development in the rat Fulltext Access 11 Pages 2016
Regular articleEpilepsy, amyloid-β, and D1 dopamine receptors: a possible pathogenetic link? Fulltext Access 11 Pages 2016
Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins Fulltext Access 11 Pages 2016
Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels Fulltext Access 11 Pages 2016
Transcriptome profiling of equine vitamin E deficient neuroaxonal dystrophy identifies upregulation of liver X receptor target genes Fulltext Access 11 Pages 2016
miR-214 protects erythroid cells against oxidative stress by targeting ATF4 and EZH2 Fulltext Access 11 Pages 2016
Epigallocatechin-3-gallate enhances key enzymatic activities of hepatic thioredoxin and glutathione systems in selenium-optimal mice but activates hepatic Nrf2 responses in selenium-deficient mice Fulltext Access 12 Pages 2016
Taurine promotes cognitive function in prenatally stressed juvenile rats via activating the Akt-CREB-PGC1α pathway Fulltext Access 12 Pages 2016
The synthetic progestin norgestrel modulates Nrf2 signaling and acts as an antioxidant in a model of retinal degeneration Fulltext Access 12 Pages 2016
Reversible glutathionylation of Sir2 by monothiol glutaredoxins Grx3/4 regulates stress resistance Fulltext Access 12 Pages 2016
Reactive oxygen species production in cardiac mitochondria after complex I inhibition: Modulation by substrate-dependent regulation of the NADH/NAD+ ratio Fulltext Access 12 Pages 2016
Glutathione-deficient Plasmodium berghei parasites exhibit growth delay and nuclear DNA damage Fulltext Access 12 Pages 2016
TRAP-positive osteoclast precursors mediate ROS/NO-dependent bactericidal activity via TLR4 Fulltext Access 12 Pages 2016
Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6 Fulltext Access 12 Pages 2016
Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer Fulltext Access 12 Pages 2016
Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production Fulltext Access 12 Pages 2016
Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4 Fulltext Access 12 Pages 2016
Protective role of biliverdin against bile acid-induced oxidative stress in liver cells Fulltext Access 12 Pages 2016
2-Oxoglutarate dehydrogenase is a more significant source of O2·â/H2O2 than pyruvate dehydrogenase in cardiac and liver tissue Fulltext Access 12 Pages 2016
Citron Rho-interacting kinase mediates arsenite-induced decrease in endothelial nitric oxide synthase activity by increasing phosphorylation at threonine 497: Mechanism underlying arsenite-induced vascular dysfunction Fulltext Access 12 Pages 2016
Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity Fulltext Access 12 Pages 2016
Key role of cysteine residues and sulfenic acids in thermal- and H2O2-mediated modification of β-lactoglobulin Fulltext Access 12 Pages 2016
Reciprocal interaction among gasotransmitters in isolated pancreatic β-cells Fulltext Access 12 Pages 2016
Dietary (-)-epicatechin mitigates oxidative stress, NO metabolism alterations, and inflammation in renal cortex from fructose-fed rats Fulltext Access 12 Pages 2016
Peroxiredoxin 6 homodimerization and heterodimerization with glutathione S-transferase pi are required for its peroxidase but not phospholipase A2 activity Fulltext Access 12 Pages 2016
Mitochondrial aldehyde dehydrogenase 2 protects gastric mucosa cells against DNA damage caused by oxidative stress Fulltext Access 12 Pages 2016
KatB, a cyanobacterial Mn-catalase with unique active site configuration: Implications for enzyme function Fulltext Access 12 Pages 2016
Connexin43 hemichannels contributes to the disassembly of cell junctions through modulation of intracellular oxidative status Fulltext Access 12 Pages 2016
The antioxidant uncoupling protein 2 stimulates hnRNPA2/B1, GLUT1 and PKM2 expression and sensitizes pancreas cancer cells to glycolysis inhibition Fulltext Access 12 Pages 2016
ROS-JNK1/2-dependent activation of autophagy is required for the induction of anti-inflammatory effect of dihydroartemisinin in liver fibrosis Fulltext Access 12 Pages 2016
MicroRNAs in heart failure: Non-coding regulators of metabolic function Fulltext Access 12 Pages 2016
123I-meta-iodobenzylguanidine (MIBG) cardiac scintigraphy in α-synucleinopathies Fulltext Access 12 Pages 2016
Oxidative instability of hemoglobin E (β26 Glu→Lys) is increased in the presence of free α subunits and reversed by α-hemoglobin stabilizing protein (AHSP): Relevance to HbE/β-thalassemia Fulltext Access 12 Pages 2016
Value of the 8-oxodG/dG ratio in chronic liver inflammation of patients with hepatocellular carcinoma Fulltext Access 12 Pages 2016
The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation Fulltext Access 12 Pages 2016
Photoprotection by dietary phenolics against melanogenesis induced by UVA through Nrf2-dependent antioxidant responses Fulltext Access 12 Pages 2016
Parkinson's disease-related gene variants influence pre-mRNA splicing processes Fulltext Access 12 Pages 2016
Changes in Drosophila mitochondrial proteins following chaperone-mediated lifespan extension confirm a role of Hsp22 in mitochondrial UPR and reveal a mitochondrial localization for cathepsin D Fulltext Access 12 Pages 2016
Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis Fulltext Access 12 Pages 2016
Designing exercise clinical trials for older adults with cancer: Recommendations from 2015 Cancer and Aging Research Group NCI U13 Meeting Fulltext Access 12 Pages 2016
Down-regulation of the mitochondrial matrix peptidase ClpP in muscle cells causes mitochondrial dysfunction and decreases cell proliferation Fulltext Access 12 Pages 2016
Fructose-derived advanced glycation end-products drive lipogenesis and skeletal muscle reprogramming via SREBP-1c dysregulation in mice Fulltext Access 12 Pages 2016
Nrf2 antioxidant defense is involved in survival signaling elicited by 27-hydroxycholesterol in human promonocytic cells Fulltext Access 12 Pages 2016
Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats Fulltext Access 12 Pages 2016
Bcl-xL-mediated antioxidant function abrogates the disruption of mitochondrial dynamics induced by LRRK2 inhibition Fulltext Access 12 Pages 2016
Nuclear receptor NR5A2 is involved in the calreticulin gene regulation during renal fibrosis Fulltext Access 12 Pages 2016
Detailed protocol to assess in vivo and ex vivo myeloperoxidase activity in mouse models of vascular inflammation and disease using hydroethidine Fulltext Access 12 Pages 2016
Endoplasmic reticulum-derived reactive oxygen species (ROS) is involved in toxicity of cell wall stress to Candida albicans Fulltext Access 12 Pages 2016
Identification of an adaptor protein that facilitates Nrf2-Keap1 complex formation and modulates antioxidant response Fulltext Access 12 Pages 2016
Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension Fulltext Access 12 Pages 2016
The TIR/BB-loop mimetic AS-1 attenuates mechanical stress-induced cardiac fibroblast activation and paracrine secretion via modulation of large tumor suppressor kinase 1 Fulltext Access 12 Pages 2016
Exclusive expression of the Rab11 effector SH3TC2 in Schwann cells links integrin-α6 and myelin maintenance to Charcot-Marie-Tooth disease type 4C Fulltext Access 12 Pages 2016
Loss of striatal 90-kDa ribosomal S6 kinase (Rsk) is a key factor for motor, synaptic and transcription dysfunction in Huntington's disease Fulltext Access 12 Pages 2016
Adolescent exposure to MDMA induces dopaminergic toxicity in substantia nigra and potentiates the amyloid plaque deposition in the striatum of APPswe/PS1dE9 mice Fulltext Access 12 Pages 2016
In vivo evidence of mitochondrial dysfunction and altered redox homeostasis in a genetic mouse model of propionic acidemia: Implications for the pathophysiology of this disorder Fulltext Access 12 Pages 2016
Novel miR-5582-5p functions as a tumor suppressor by inducing apoptosis and cell cycle arrest in cancer cells through direct targeting of GAB1, SHC1, and CDK2 Fulltext Access 12 Pages 2016
HDAC6 alleviates prion peptide-mediated neuronal death via modulating PI3K-Akt-mTOR pathway Fulltext Access 12 Pages 2016
Missense mutations in progranulin gene associated with frontotemporal lobar degeneration: study of pathogenetic features Fulltext Access 12 Pages 2016
MRI-based brain atrophy rates in ADNI phase 2: acceleration and enrichment considerations for clinical trials Fulltext Access 12 Pages 2016
Aging-associated changes in motor axon voltage-gated Na+ channel function in mice Fulltext Access 12 Pages 2016
Metabolic changes over the course of aging in a mouse model of tau deposition Fulltext Access 12 Pages 2016
The presence of heterogeneous nuclear ribonucleoproteins in frontotemporal lobar degeneration with FUS-positive inclusions Fulltext Access 12 Pages 2016
Mitochondrial ferritin affects mitochondria by stabilizing HIF-1α in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration Fulltext Access 12 Pages 2016