D-ribose-glycation of insulin prevents amyloid aggregation and produces cytotoxic adducts Fulltext Access 12 Pages 2016
A cardiac myocyte-restricted Lin28/let-7 regulatory axis promotes hypoxia-mediated apoptosis by inducing the AKT signaling suppressor PIK3IP1 Fulltext Access 12 Pages 2016
Hexa (ethylene glycol) derivative of benzothiazole aniline promotes dendritic spine formation through the RasGRF1–Ras dependent pathway Fulltext Access 12 Pages 2016
Peroxiredoxin-2 nitrosylation facilitates cardiomyogenesis of mouse embryonic stem cells via XBP-1s/PI3K pathway Fulltext Access 13 Pages 2016
The MAOA, COMT, MTHFR and ESR1 gene polymorphisms are associated with the risk of depression in menopausal women Fulltext Access 13 Pages 2016
Antigen presenting cell abnormalities in the Cln3â/â mouse model of juvenile neuronal ceroid lipofuscinosis Fulltext Access 13 Pages 2016
Suppression of PKC-α attenuates TNF-α-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen-plasmin system Fulltext Access 13 Pages 2016
A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytes Fulltext Access 13 Pages 2016
Organ-specific alteration in caspase expression and STK3 proteolysis during the aging process Fulltext Access 13 Pages 2016
Toxicity, bio-distribution and metabolism of CO-releasing molecules based on cobalt Fulltext Access 13 Pages 2016
Induction of mitochondrial reactive oxygen species production by GSH mediated S-glutathionylation of 2-oxoglutarate dehydrogenase Fulltext Access 13 Pages 2016
Oncogenic circuit constituted by Ser31-HBx and Akt increases risks of chronic hepatitis and hepatocellular carcinoma Fulltext Access 13 Pages 2016
Tat-PRAS40 prevent hippocampal HT-22 cell death and oxidative stress induced animal brain ischemic insults Fulltext Access 13 Pages 2016
Caffeic acid phenethyl ester alleviates asthma by regulating the airway microenvironment via the ROS-responsive MAPK/Akt pathway Fulltext Access 13 Pages 2016
Envejecimiento activo y de éxito o saludable: una breve historia de modelos conceptuales Fulltext Access 13 Pages 2016
NOX4 supports glycolysis and promotes glutamine metabolism in non-small cell lung cancer cells Fulltext Access 13 Pages 2016
Peroxiredoxin 5 (Prx5) decreases LPS-induced microglial activation through regulation of Ca2+/calcineurin-Drp1-dependent mitochondrial fission Fulltext Access 13 Pages 2016
Sestrin2 inhibits hypoxia-inducible factor-1α accumulation via AMPK-mediated prolyl hydroxylase regulation Fulltext Access 13 Pages 2016
Investigating mitochondrial redox state using NADH and NADPH autofluorescence Fulltext Access 13 Pages 2016
Peroxiredoxin 6 expression is inversely correlated with nuclear factor-κB activation during Clonorchis sinensis infestation Fulltext Access 13 Pages 2016
Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence Fulltext Access 13 Pages 2016
C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins Fulltext Access 13 Pages 2016
Frequent inactivation of MCC/CTNNBIP1 and overexpression of phospho-beta-cateninY654 are associated with breast carcinoma: Clinical and prognostic significance Fulltext Access 13 Pages 2016
Mitochondrial ClpP activity is required for cisplatin resistance in human cells. Fulltext Access 13 Pages 2016
Bone marrow-derived macrophages and the CNS: An update on the use of experimental chimeric mouse models and bone marrow transplantation in neurological disorders Fulltext Access 13 Pages 2016
Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways Fulltext Access 13 Pages 2016
TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation Fulltext Access 13 Pages 2016
Chronic vagus nerve stimulation attenuates vascular endothelial impairments and reduces the inflammatory profile via inhibition of the NF-κB signaling pathway in ovariectomized rats Fulltext Access 13 Pages 2016
The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass Fulltext Access 13 Pages 2016
The neutral sphingomyelinase-2 is involved in angiogenic signaling triggered by oxidized LDL Fulltext Access 13 Pages 2016
Unique cistrome defined as CsMBE is strictly required for Nrf2-sMaf heterodimer function in cytoprotection Fulltext Access 13 Pages 2016
Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling Fulltext Access 13 Pages 2016
Hepatocyte-specific Keap1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development Fulltext Access 13 Pages 2016
Distinct oxidative cleavage and modification of bovine [Cu- Zn]-SOD by an ascorbic acid/Cu(II) system: Identification of novel copper binding site on SOD molecule Fulltext Access 13 Pages 2016
The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome Fulltext Access 14 Pages 2016
Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways Fulltext Access 14 Pages 2016
Nanoceria restrains PM2.5-induced metabolic disorder and hypothalamus inflammation by inhibition of astrocytes activation related NF-κB pathway in Nrf2 deficient mice Fulltext Access 14 Pages 2016
Altered mitochondrial dynamics and response to insulin in cybrid cells harboring a diabetes-susceptible mitochondrial DNA haplogroup Fulltext Access 14 Pages 2016
Mitochondrial permeabilization without caspase activation mediates the increase of basal apoptosis in cells lacking Nrf2 Fulltext Access 14 Pages 2016
Mitochondrial impairments contribute to Spinocerebellar ataxia type 1 progression and can be ameliorated by the mitochondria-targeted antioxidant MitoQ Fulltext Access 14 Pages 2016
LZ-106, a novel analog of enoxacin, inducing apoptosis via activation of ROS-dependent DNA damage response in NSCLCs Fulltext Access 14 Pages 2016
Redox chemistry of Mycobacterium tuberculosis alkylhydroperoxide reductase E (AhpE): Structural and mechanistic insight into a mycoredoxin-1 independent reductive pathway of AhpE via mycothiol Fulltext Access 14 Pages 2016
Leukoencephalopathy with thalamus and brainstem involvement and high lactate caused by novel mutations in the EARS2 gene in two siblings Fulltext Access 14 Pages 2016
The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells Fulltext Access 14 Pages 2016
Aging is associated with dimerization and inactivation of the brain-enriched tyrosine phosphatase STEP Fulltext Access 14 Pages 2016
Complex coordinated extracellular metabolism: Acid phosphatases activate diluted human leukocyte proteins to generate energy flow as NADPH from purine nucleotide ribose Fulltext Access 14 Pages 2016
Direct measurement of actual levels of nitric oxide (NO) in cell culture conditions using soluble NO donors Fulltext Access 14 Pages 2016
Infertility and recurrent miscarriage with complex II deficiency-dependent mitochondrial oxidative stress in animal models Fulltext Access 14 Pages 2016
Original articleGlutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes Fulltext Access 14 Pages 2016
Comparative effects of diet and carcinogen on microRNA expression in the stem cell niche of the mouse colonic crypt Fulltext Access 14 Pages 2016
Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition Fulltext Access 14 Pages 2016
Caspase-cleaved Tau-D421 is colocalized with the immunophilin FKBP52 in the autophagy-endolysosomal system of Alzheimer's disease neurons Fulltext Access 14 Pages 2016
Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis Fulltext Access 14 Pages 2016
Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models Fulltext Access 14 Pages 2016
Long-term effect of PROLI/NO on cellular proliferation and phenotype after arterial injury Fulltext Access 15 Pages 2016
Caloric restriction and the precision-control of autophagy: A strategy for delaying neurodegenerative disease progression Fulltext Access 15 Pages 2016
DHA-induced stress response in human colon cancer cells - Focus on oxidative stress and autophagy Fulltext Access 15 Pages 2016
A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways Fulltext Access 15 Pages 2016
Lipoxin A4 attenuates LPS-induced mouse acute lung injury via Nrf2-mediated E-cadherin expression in airway epithelial cells Fulltext Access 15 Pages 2016
Cytochrome P450-2E1 promotes aging-related hepatic steatosis, apoptosis and fibrosis through increased nitroxidative stress Fulltext Access 15 Pages 2016
Liraglutide protects cardiac microvascular endothelial cells against hypoxia/reoxygenation injury through the suppression of the SR-Ca2+-XO-ROS axis via activation of the GLP-1R/PI3K/Akt/survivin pathways Fulltext Access 15 Pages 2016
Rupestonic acid derivative YZH-106 suppresses influenza virus replication by activation of heme oxygenase-1-mediated interferon response Fulltext Access 15 Pages 2016
Nrf2 signaling and redox homeostasis in the aging heart: A potential target to prevent cardiovascular diseases? Fulltext Access 15 Pages 2016
The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: In vitro and in vivo studies Fulltext Access 15 Pages 2016
Dl-3-n-butylphthalide-induced upregulation of antioxidant defense is involved in the enhancement of cross talk between CREB and Nrf2 in an Alzheimer's disease mouse model Fulltext Access 15 Pages 2016
CellNO trap: Novel device for quantitative, real-time, direct measurement of nitric oxide from cultured RAW 267.4 macrophages Fulltext Access 15 Pages 2016
S-nitrosylation of endogenous protein tyrosine phosphatases in endothelial insulin signaling Fulltext Access 15 Pages 2016
Effects of muscular dystrophy, exercise and blocking activin receptor IIB ligands on the unfolded protein response and oxidative stress Fulltext Access 15 Pages 2016
Thioredoxin-mimetic peptides (TXM) inhibit inflammatory pathways associated with high-glucose and oxidative stress Fulltext Access 15 Pages 2016
Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development Fulltext Access 16 Pages 2016
Estrogen receptor β actions in the female cardiovascular system: A systematic review of animal and human studies Fulltext Access 16 Pages 2016
Directly interact with Keap1 and LPS is involved in the anti-inflammatory mechanisms of (-)-epicatechin-3-gallate in LPS-induced macrophages and endotoxemia Fulltext Access 16 Pages 2016
Effects of transgenic methionine sulfoxide reductase A (MsrA) expression on lifespan and age-dependent changes in metabolic function in mice Fulltext Access 16 Pages 2016
The homocysteine associated variant rs548987 of SLC17A3 confers susceptibility to ischemic stroke in Chinese population Fulltext Access 16 Pages 2016
Assessment of electrophile damage in a human brain endothelial cell line utilizing a clickable alkyne analog of 2-chlorohexadecanal Fulltext Access 16 Pages 2016
Increases in intracellular calcium perturb blood-brain barrier via protein kinase C-alpha and apoptosis Fulltext Access 16 Pages 2016
Update on the spider and the fly: An extended commentary on “Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-Oxidase activation” Fulltext Access 16 Pages 2016
rs2802292 polymorphism in the FOXO3A gene and exceptional longevity in two ethnically distinct cohorts Fulltext Access 16 Pages 2016
Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease Fulltext Access 16 Pages 2016
A novel 10-base pair insertion mutation in exon 5 of the SOD1 gene in a Chinese family with amyotrophic lateral sclerosis Fulltext Access 17 Pages 2016
Microablative fractional CO2-laser therapy and the genitourinary syndrome of menopause: An observational study Fulltext Access 17 Pages 2016
Neurorehabilitation for Parkinson's disease: Future perspectives for behavioural adaptation Fulltext Access 17 Pages 2016
Regulation of endothelial dynamics by PGC-1α relies on ROS control of VEGF-A signaling Fulltext Access 17 Pages 2016
Impaired Nrf2 regulation of mitochondrial biogenesis in rostral ventrolateral medulla on hypertension induced by systemic inflammation Fulltext Access 17 Pages 2016
Cognitive study on Chinese patients with idiopathic REM sleep behavior disorder Fulltext Access 18 Pages 2016
Focal status epilepticus as a manifestation of idiopathic hypertrophic cranial pachymeningitis Fulltext Access 18 Pages 2016
Analysis of the retinal nerve fiber and ganglion cell - Inner plexiform layer by optical coherence tomography in Parkinson's patients Fulltext Access 18 Pages 2016
The neuron-astrocyte-microglia triad involvement in neuroinflammaging mechanisms in the CA3 hippocampus of memory-impaired aged rats Fulltext Access 18 Pages 2016
Apolipoprotein E ε4 does not affect cognitive performance in patients with Parkinson's disease Fulltext Access 18 Pages 2016
Cerulein-induced pancreatic fibrosis is modulated by Smad7, the major negative regulator of transforming growth factor-β signaling Fulltext Access 18 Pages 2016
Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells Fulltext Access 18 Pages 2016