Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning Fulltext Access 12 Pages 2013
Δ9-THC-Caused Synaptic and Memory Impairments Are Mediated through COX-2 Signaling Fulltext Access 12 Pages 2013
Probabilistic Splicing of Dscam1 Establishes Identity at the Level of Single Neurons Fulltext Access 12 Pages 2013
Sonic Hedgehog Signaling Switches the Mode of Division in the Developing Nervous System Fulltext Access 12 Pages 2013
Identification of PHRF1 as a Tumor Suppressor that Promotes the TGF-β Cytostatic Program through Selective Release of TGIF-Driven PML Inactivation Fulltext Access 12 Pages 2013
Integrating Genomic, Epigenomic, and Transcriptomic Features Reveals Modular Signatures Underlying Poor Prognosis in Ovarian Cancer Fulltext Access 12 Pages 2013
Low-Affinity T Cells Are Programmed to Maintain Normal Primary Responses but Are Impaired in Their Recall to Low-Affinity Ligands Fulltext Access 12 Pages 2013
Chronic Lymphocytic Leukemia Cells Are Activated and Proliferate in Response to Specific T Helper Cells Fulltext Access 12 Pages 2013
Precise Developmental Gene Expression Arises from Globally Stochastic Transcriptional Activity Fulltext Access 12 Pages 2013
The Ubiquitin Receptor S5a/Rpn10 Links Centrosomal Proteasomes with Dendrite Development in the Mammalian Brain Fulltext Access 12 Pages 2013
5S Ribosomal RNA Is an Essential Component of a Nascent Ribosomal Precursor Complex that Regulates the Hdm2-p53 Checkpoint Fulltext Access 12 Pages 2013
PLK1 Signaling in Breast Cancer Cells Cooperates with Estrogen Receptor-Dependent Gene Transcription Fulltext Access 12 Pages 2013
An iPSC Line from Human Pancreatic Ductal Adenocarcinoma Undergoes Early to Invasive Stages of Pancreatic Cancer Progression Fulltext Access 12 Pages 2013
Cellular Source and Mechanisms of High Transcriptome Complexity in the Mammalian Testis Fulltext Access 12 Pages 2013
Generation of Integration-free and Region-Specific Neural Progenitors from Primate Fibroblasts Fulltext Access 12 Pages 2013
PU.1 Level-Directed Chromatin Structure Remodeling at the Irf8 Gene Drives Dendritic Cell Commitment Fulltext Access 12 Pages 2013
Phosphorylation-Regulated Binding of RNA Polymerase II to Fibrous Polymers of Low-Complexity Domains Fulltext Access 12 Pages 2013
Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle Fulltext Access 12 Pages 2013
A Nanobody-Based System Using Fluorescent Proteins as Scaffolds for Cell-Specific Gene Manipulation Fulltext Access 12 Pages 2013
Incisive Imaging and Computation for Cellular Mysteries: Lessons from Abscission Fulltext Access 12 Pages 2013
Genetically Encoded Chemical Probes in Cells Reveal the Binding Path of Urocortin-I to CRF Class B GPCR Fulltext Access 12 Pages 2013
Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity Fulltext Access 12 Pages 2013
Sperm, but Not Oocyte, DNA Methylome Is Inherited by Zebrafish Early Embryos Fulltext Access 12 Pages 2013
Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy Fulltext Access 12 Pages 2013
Single Naive CD4+ T Cells from a Diverse Repertoire Produce Different Effector Cell Types during Infection Fulltext Access 12 Pages 2013
A Polymorphism in IRF4 Affects Human Pigmentation through a Tyrosinase-Dependent MITF/TFAP2A Pathway Fulltext Access 12 Pages 2013
Increased Expression of Enzymes of Triglyceride Synthesis Is Essential for the Development of Hepatic Steatosis Fulltext Access 13 Pages 2013
TDP-43 Loss-of-Function Causes Neuronal Loss Due to Defective Steroid Receptor-Mediated Gene Program Switching in Drosophila Fulltext Access 13 Pages 2013
Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation Fulltext Access 13 Pages 2013
Addiction of t(8;21) and inv(16) Acute Myeloid Leukemia to Native RUNX1 Fulltext Access 13 Pages 2013
The emergence of influenza A H7N9 in human beings 16 years after influenza A H5N1: a tale of two cities Fulltext Access 13 Pages 2013
The Serine Hydrolase ABHD6 Is a Critical Regulator of the Metabolic Syndrome Fulltext Access 13 Pages 2013
Spontaneous Lytic Replication and Epitheliotropism Define an Epstein-Barr Virus Strain Found in Carcinomas Fulltext Access 13 Pages 2013
Pluripotent Stem Cell Protein Sox2 Confers Sensitivity to LSD1 Inhibition in Cancer Cells Fulltext Access 13 Pages 2013
Integrin-Matrix Clusters Form Podosome-like Adhesions in the Absence of Traction Forces Fulltext Access 13 Pages 2013
Structural Basis for Enhanced HIV-1 Neutralization by a Dimeric Immunoglobulin G Form of the Glycan-Recognizing Antibody 2G12 Fulltext Access 13 Pages 2013
Transcription Factors Mediate the Enzymatic Disassembly of Promoter-Bound 7SK snRNP to Locally Recruit P-TEFb for Transcription Elongation Fulltext Access 13 Pages 2013
An IKKα-Nucleophosmin Axis Utilizes Inflammatory Signaling to Promote Genome Integrity Fulltext Access 13 Pages 2013
DUB-Resistant Ubiquitin to Survey Ubiquitination Switches in Mammalian Cells Fulltext Access 13 Pages 2013
Feedback Regulation of Receptor-Induced Ca2+ Signaling Mediated by E-Syt1 and Nir2 at Endoplasmic Reticulum-Plasma Membrane Junctions Fulltext Access 13 Pages 2013
Combinatorial H3K9acS10ph Histone Modification in IgH Locus S Regions Targets 14-3-3 Adaptors and AID to Specify Antibody Class-Switch DNA Recombination Fulltext Access 13 Pages 2013
DCC Expression by Neurons Regulates Synaptic Plasticity in the Adult Brain Fulltext Access 13 Pages 2013
Analysis of the DNA-Binding Profile and Function of TALE Homeoproteins Reveals Their Specialization and Specific Interactions with Hox Genes/Proteins Fulltext Access 13 Pages 2013
A Feedback Regulatory Loop between G3P and Lipid Transfer Proteins DIR1 and AZI1 Mediates Azelaic-Acid-Induced Systemic Immunity Fulltext Access 13 Pages 2013
Silencing the Majority of Cerebellar Granule Cells Uncovers Their Essential Role in Motor Learning and Consolidation Fulltext Access 13 Pages 2013
Plantas con actividad fotosensibilizadora y potencial terapéutico en leishmaniasis cutánea: hipericina, una alternativa prometedora Fulltext Access 13 Pages 2013
Modeling Neural Crest Induction, Melanocyte Specification, and Disease-Related Pigmentation Defects in hESCs and Patient-Specific iPSCs Fulltext Access 13 Pages 2013
Definition of RNA Polymerase II CoTC Terminator Elements in the Human Genome Fulltext Access 13 Pages 2013
Eukaryotic Replisome Components Cooperate to Process Histones During Chromosome Replication Fulltext Access 13 Pages 2013
ABH2 Couples Regulation of Ribosomal DNA Transcription with DNA Alkylation Repair Fulltext Access 13 Pages 2013
Glycine Receptor α2 Subunit Activation Promotes Cortical Interneuron Migration Fulltext Access 13 Pages 2013
The Deubiquitinase USP28 Stabilizes LSD1 and Confers Stem-Cell-like Traits to Breast Cancer Cells Fulltext Access 13 Pages 2013
TRF2 Interaction with Ku Heterotetramerization Interface Gives Insight into c-NHEJ Prevention at Human Telomeres Fulltext Access 13 Pages 2013
Transcriptome Surveillance by Selective Termination of Noncoding RNA Synthesis Fulltext Access 13 Pages 2013
Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing Fulltext Access 13 Pages 2013
A Systematic Approach for the Genetic Dissection of Protein Complexes in Living Cells Fulltext Access 13 Pages 2013
The Genomic Landscape of the Somatic Linker Histone Subtypes H1.1 to H1.5 in Human Cells Fulltext Access 13 Pages 2013
DNA-Damage-Induced Nuclear Export of Precursor MicroRNAs Is Regulated by the ATM-AKT Pathway Fulltext Access 13 Pages 2013
SOX2 Regulates YAP1 to Maintain Stemness and Determine Cell Fate in the Osteo-Adipo Lineage Fulltext Access 13 Pages 2013
The Ku Heterodimer and the Metabolism of Single-Ended DNA Double-Strand Breaks Fulltext Access 13 Pages 2013
Commensal Microbiota Are Required for Systemic Inflammation Triggered by Necrotic Dendritic Cells Fulltext Access 13 Pages 2013
Structural Basis for LMO2-Driven Recruitment of the SCL:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets Fulltext Access 13 Pages 2013
RhoGAPs Attenuate Cell Proliferation by Direct Interaction with p53 Tetramerization Domain Fulltext Access 13 Pages 2013
Circadian Control of Global Gene Expression by the Cyanobacterial Master Regulator RpaA Fulltext Access 13 Pages 2013
High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis Fulltext Access 13 Pages 2013
Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module Fulltext Access 13 Pages 2013
Vaccinia Virus Entry Is Followed by Core Activation and Proteasome-Mediated Release of the Immunomodulatory Effector VH1 from Lateral Bodies Fulltext Access 13 Pages 2013
Roquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs Fulltext Access 13 Pages 2013
An Aberrant Transcription Factor Network Essential for Wnt Signaling and Stem Cell Maintenance in Glioblastoma Fulltext Access 13 Pages 2013
A Fasting-Responsive Signaling Pathway that Extends Life Span in C. elegans Fulltext Access 13 Pages 2013
Endothelial Jagged-1 Is Necessary for Homeostatic and Regenerative Hematopoiesis Fulltext Access 13 Pages 2013
Molecular Basis for DNA Double-Strand Break Annealing and Primer Extension by an NHEJ DNA Polymerase Fulltext Access 13 Pages 2013
ATR Activates the S-M Checkpoint during Unperturbed Growth to Ensure Sufficient Replication Prior to Mitotic Onset Fulltext Access 13 Pages 2013
High-Frequency Promoter Firing Links THO Complex Function to Heavy Chromatin Formation Fulltext Access 13 Pages 2013
Combined Targeting of JAK2 and Bcl-2/Bcl-xL to Cure Mutant JAK2-Driven Malignancies and Overcome Acquired Resistance to JAK2 Inhibitors Fulltext Access 13 Pages 2013
The Circadian Molecular Clock Regulates Adult Hippocampal Neurogenesis by Controlling the Timing of Cell-Cycle Entry and Exit Fulltext Access 13 Pages 2013
MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity Fulltext Access 13 Pages 2013
A Vibrio parahaemolyticus T3SS Effector Mediates Pathogenesis by Independently Enabling Intestinal Colonization and Inhibiting TAK1 Activation Fulltext Access 13 Pages 2013
Transcription Factor Binding in Human Cells Occurs in Dense Clusters Formed around Cohesin Anchor Sites Fulltext Access 13 Pages 2013
The Yeast Ski Complex: Crystal Structure and RNA Channeling to the Exosome Complex Fulltext Access 13 Pages 2013
Exploitation of Latent Allostery Enables the Evolution of New Modes of MAP Kinase Regulation Fulltext Access 13 Pages 2013
S6K1 Alternative Splicing Modulates Its Oncogenic Activity and Regulates mTORC1 Fulltext Access 13 Pages 2013
PRMT4 Blocks Myeloid Differentiation by Assembling a Methyl-RUNX1-Dependent Repressor Complex Fulltext Access 14 Pages 2013
Switch Enhancers Interpret TGF-β and Hippo Signaling to Control Cell Fate in Human Embryonic Stem Cells Fulltext Access 14 Pages 2013