Quercetin and baicalein suppress monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats Fulltext Access 9 Pages 2017
Protective effect of betulinic acid on early atherosclerosis in diabetic apolipoprotein-E gene knockout mice Fulltext Access 9 Pages 2017
Isoliquiritigenin inhibits TNF-α-induced release of high-mobility group box 1 through activation of HDAC in human intestinal epithelial HT-29 cells Fulltext Access 9 Pages 2017
Mefloquine inhibits voltage dependent Nav1.4 channel by overlapping the local anaesthetic binding site Fulltext Access 9 Pages 2017
Betaine attenuates memory impairment after water-immersion restraint stress and is regulated by the GABAergic neuronal system in the hippocampus Fulltext Access 9 Pages 2017
Tanshinone IIA induced cell death via miR30b-p53-PTPN11/SHP2 signaling pathway in human hepatocellular carcinoma cells Fulltext Access 9 Pages 2017
Penehyclidine hydrochloride prevents anoxia/reoxygenation injury and induces H9c2 cardiomyocyte apoptosis via a mitochondrial pathway Fulltext Access 9 Pages 2017
Rho-kinase inhibitor prevents acute injury against transient focal cerebral ischemia by enhancing the expression and function of GABA receptors in rats Fulltext Access 9 Pages 2017
Cucurbitacin B purified from Ecballium elaterium (L.) A. Rich from Tunisia inhibits α5β1 integrin-mediated adhesion, migration, proliferation of human glioblastoma cell line and angiogenesis Fulltext Access 9 Pages 2017
Antihyperalgesic effect of CB1 receptor activation involves the modulation of P2X3 receptor in the primary afferent neuron Fulltext Access 9 Pages 2017
Spinal astrocytic c-Jun N-terminal kinase (JNK) activation as counteracting mechanism to the amitriptyline analgesic efficacy in painful peripheral neuropathies Fulltext Access 9 Pages 2017
Protective effect of Nrf2-ARE activator isolated from green perilla leaves on dopaminergic neuronal loss in a Parkinson's disease model Fulltext Access 9 Pages 2017
Epigallocatechin-3-gallate inhibits adipogenesis through down-regulation of PPARγ and FAS expression mediated by PI3K-AKT signaling in 3T3-L1 cells Fulltext Access 9 Pages 2017
Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes Fulltext Access 9 Pages 2017
A comparison of vasodilation mode among selexipag (NS-304; [2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide]), its active metabolite MRE-269 and various prostacyclin receptor agonists in rat, porcine and human pulmonar Fulltext Access 9 Pages 2017
Protective effect of 3H-1, 2-dithiole-3-thione on cellular model of Alzheimer's disease involves Nrf2/ARE signaling pathway Fulltext Access 9 Pages 2017
Activating AKT to inhibit JNK by troxerutin antagonizes radiation-induced PTEN activation Fulltext Access 9 Pages 2017
A novel urotensin II receptor antagonist, KR-36996, improved cardiac function and attenuated cardiac hypertrophy in experimental heart failure Fulltext Access 9 Pages 2017
HIV antiretroviral drug Efavirenz induces anxiety-like and depression-like behavior in rats: evaluation of neurotransmitter alterations in the striatum Fulltext Access 9 Pages 2017
ErbB4 cleavage by gonadotropin-releasing hormone receptor stimulation in cultured gonadotroph cells Fulltext Access 9 Pages 2017
Further analysis of the inhibition by agmatine on the cardiac sympathetic outflow: Role of the α2-adrenoceptor subtypes Fulltext Access 9 Pages 2017
Pharmacological evidence for systemic and peripheral antinociceptive activities of pioglitazone in the rat formalin test: Role of PPARγ and nitric oxide Fulltext Access 9 Pages 2017
The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice Fulltext Access 9 Pages 2017
Simultaneous targeting of CD14 and factor XIa by a fusion protein consisting of an anti-CD14 antibody and the modified second domain of bikunin improves survival in rabbit sepsis models Fulltext Access 9 Pages 2017
In vitro neurotoxic hazard characterization of different tricresyl phosphate (TCP) isomers and mixtures Fulltext Access 9 Pages 2017
Repeated asenapine treatment does not participate in the mild stress induced FosB/ÎFosB expression in the rat hypothalamic paraventricular nucleus neurons Fulltext Access 9 Pages 2017
Neuropeptide Y neuronal network dysfunction in the frontal lobe of a genetic mouse model of schizophrenia Fulltext Access 9 Pages 2017
Embryonic ablation of neuronal VGF increases energy expenditure and reduces body weight Fulltext Access 9 Pages 2017
Centrally located GLP-1 receptors modulate gastric slow waves and cardiovascular function in ferrets consistent with the induction of nausea Fulltext Access 9 Pages 2017
Analgesic and anxiolytic effects of [Leu31,Pro34]-neuropeptide Y microinjected into the periaqueductal gray in rats Fulltext Access 9 Pages 2017
Anti-atherosclerotic effect of hesperidin in LDLrâ/â mice and its possible mechanism Fulltext Access 9 Pages 2017
Antinociception induced by a novel α2A adrenergic receptor agonist in rodents acute and chronic pain models Fulltext Access 9 Pages 2017
Homoharringtonine prevents surgery-induced epidural fibrosis through endoplasmic reticulum stress signaling pathway Fulltext Access 9 Pages 2017
Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization Fulltext Access 9 Pages 2017
Evaluation of the neurotoxic effects of chronic embryonic exposure with inorganic mercury on motor and anxiety-like responses in zebrafish (Danio rerio) larvae Fulltext Access 9 Pages 2017
Full length articlePrenatal and postnatal polybrominated diphenyl ether (PBDE) exposure and measures of inattention and impulsivity in children Fulltext Access 9 Pages 2017
p73 gene in dopaminergic neurons is highly susceptible to manganese neurotoxicity Fulltext Access 9 Pages 2017
Modulation by NADPH oxidase of the chronic cardiovascular and autonomic interaction between cyclosporine and NSAIDs in female rats Fulltext Access 9 Pages 2017
Carbon disulfide potentiates the effects of impulse noise on the organ of Corti Fulltext Access 9 Pages 2017
Fluoride and arsenic exposure affects spatial memory and activates the ERK/CREB signaling pathway in offspring rats Fulltext Access 9 Pages 2017
Neonatal exposure to BDE 209 impaired learning and memory, decreased expression of hippocampal core SNAREs and synaptophysin in adult rats Fulltext Access 9 Pages 2017
Modeling U-shaped dose-response curves for manganese using categorical regression Fulltext Access 9 Pages 2017
Association of neurobehavioral performance with R2* in the caudate nucleus of asymptomatic welders Fulltext Access 9 Pages 2017
Pharmacological characterization of histamine-gated chloride channels from the housefly Musca domestica Fulltext Access 9 Pages 2017
Alternative in vitro assays to assess the potency of sensory irritants-Is one TRP channel enough? Fulltext Access 9 Pages 2017
Potential mechanisms of development-dependent adverse effects of the herbicide paraquat in 3D rat brain cell cultures Fulltext Access 9 Pages 2017
Hypoxia and nicotine effects on Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor 1 (PAC1) in the developing piglet brainstem Fulltext Access 9 Pages 2017
Toluene exposure enhances acute and chronic formalin-induced nociception in rats: Participation of 5-HT3 receptors Fulltext Access 9 Pages 2017
Enhanced legumain-recognition and NIR controlled released of cisplatin-indocyanine nanosphere against gastric carcinoma Fulltext Access 9 Pages 2017
AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids Fulltext Access 9 Pages 2017
Tramadol: Effects on sexual behavior in male rats are mainly caused by its 5-HT reuptake blocking effects Fulltext Access 9 Pages 2017
The discriminative stimulus effects of i.v. nicotine in rhesus monkeys: Pharmacokinetics and apparent pA2 analysis with dihydro-β-erythroidine Fulltext Access 9 Pages 2017
Opposite control of mesocortical and mesoaccumbal dopamine pathways by serotonin2B receptor blockade: Involvement of medial prefrontal cortex serotonin1A receptors Fulltext Access 9 Pages 2017
Properties of the corticostriatal long term depression induced by medial prefrontal cortex high frequency stimulation in vivo Fulltext Access 9 Pages 2017
Locomotor sensitization to intermittent ketamine administration is associated with nucleus accumbens plasticity in male and female rats Fulltext Access 9 Pages 2017
CRFR1 in the ventromedial caudate putamen modulates acute stress-enhanced expression of cocaine locomotor sensitization Fulltext Access 9 Pages 2017
The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes Fulltext Access 9 Pages 2017
Facial pain and anxiety-like behavior are reduced by pregabalin in a model of facial carcinoma in rats Fulltext Access 9 Pages 2017
Mutation of the inhibitory ethanol site in GABAA Ï1 receptors promotes tolerance to ethanol-induced motor incoordination Fulltext Access 9 Pages 2017
Hippocampal 5-HT1A receptor expression changes in prodromal stages of Alzheimer's disease: Beneficial or deleterious? Fulltext Access 9 Pages 2017
The novel multitarget iron chelating and propargylamine drug M30 affects APP regulation and processing activities in Alzheimer's disease models Fulltext Access 9 Pages 2017
Cannabidiol reduces brain damage and improves functional recovery in a neonatal rat model of arterial ischemic stroke Fulltext Access 9 Pages 2017
Candesartan prevents resiniferatoxin-induced sensory small-fiber neuropathy in mice by promoting angiotensin II-mediated AT2 receptor stimulation Fulltext Access 9 Pages 2017
Anesthetics inhibit extracellular signal-regulated Kinase1/2 phosphorylation via NMDA receptor, phospholipase C and protein kinase C in mouse hippocampal slices Fulltext Access 9 Pages 2017
Type-I interferon signalling through IFNAR1 plays a deleterious role in the outcome after stroke Fulltext Access 9 Pages 2017
Functional research and molecular mechanism of Kainic acid-induced denitrosylation of thioredoxin-1 in rat hippocampus Fulltext Access 9 Pages 2017
ALCAR promote adult hippocampal neurogenesis by regulating cell-survival and cell death-related signals in rat model of Parkinson's disease like-phenotypes Fulltext Access 9 Pages 2017
Decreased spinal endomorphin-2 contributes to mechanical allodynia in streptozotocin-induced diabetic rats Fulltext Access 9 Pages 2017
Glucagon-like petide-2 acts on colon cancer myofibroblasts to stimulate proliferation, migration and invasion of both myofibroblasts and cancer cells via the IGF pathway Fulltext Access 9 Pages 2017
Antimicrobial and immunomodulatory activity of host defense peptides, clavanins and LL-37, in vitro: An endodontic perspective Fulltext Access 9 Pages 2017
Cardioprotective effect of nesfatin-1 against isoproterenol-induced myocardial infarction in rats: Role of the Akt/GSK-3β pathway Fulltext Access 9 Pages 2017
Identification of mature peptides from pban and capa genes of the moths Heliothis peltigera and Spodoptera littoralis Fulltext Access 9 Pages 2017
Research ArticleCationic peptides from peptic hydrolysates of rice endosperm protein exhibit antimicrobial, LPS-neutralizing, and angiogenic activities Fulltext Access 9 Pages 2017
Endogenous and synthetic neuroactive steroids evoke sustained increases in the efficacy of GABAergic inhibition via a protein kinase C-dependent mechanism Fulltext Access 9 Pages 2017
L-F001, a novel multifunctional ROCK inhibitor, suppresses neuroinflammation in vitro and in vivo: Involvement of NF-κB inhibition and Nrf2 pathway activation Fulltext Access 9 Pages 2017
n-Propyl gallate suppresses lipopolysaccharide-induced inducible nitric oxide synthase activation through protein kinase Cδ-mediated up-regulation of heme oxygenase-1 in RAW264.7 macrophages Fulltext Access 9 Pages 2017
Characterization of 6-methoxyflavanone as a novel anxiolytic agent: A behavioral and pharmacokinetic approach Fulltext Access 9 Pages 2017
The superoxide dismutase mimetic tempol blunts diabetes-induced upregulation of NADPH oxidase and endoplasmic reticulum stress in a rat model of diabetic nephropathy Fulltext Access 9 Pages 2017
A new benzenediamine derivative modulates Toll-like receptors-induced myeloid dendritic cells activation and ameliorates lupus-like syndrome in MRLlpr/lpr mice Fulltext Access 9 Pages 2017
Inhibition of agonist-induced smooth muscle contraction by picotamide in the male human lower urinary tract outflow region Fulltext Access 9 Pages 2017
Effects of the fibroblast activation protein inhibitor, PT100, in a murine model of pulmonary fibrosis Fulltext Access 9 Pages 2017
Targeting human telomerase RNA component using antisense oligonucleotide induces rapid cell death and increases ATO-induced apoptosis in APL cells Fulltext Access 9 Pages 2017
RP5063, a novel, multimodal, serotonin receptor modulator, prevents Sugen 5416-hypoxia-induced pulmonary arterial hypertension in rats Fulltext Access 9 Pages 2017
Antidepressant-like effects of YL-IPA08, a potent ligand for the translocator protein (18Â kDa) in chronically stressed rats Fulltext Access 9 Pages 2017
Dysregulated corticostriatal activity in open-field behavior and the head-twitch response induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine Fulltext Access 9 Pages 2017
GABAÏ selective antagonist TPMPA partially inhibits GABA-mediated currents recorded from neurones and astrocytes in mouse striatum Fulltext Access 9 Pages 2017
Structure-activity relationship of linear tetrapeptides Tic-DPhe-Arg-Trp-NH2 at the human melanocortin-4 receptor and effects on feeding behaviors in rat Fulltext Access 9 Pages 2017
GluN1 deletions in D1- and A2A-expressing cell types reveal distinct modes of behavioral regulation Fulltext Access 9 Pages 2017
Integrated regulation of AMPA glutamate receptor phosphorylation in the striatum by dopamine and acetylcholine Fulltext Access 9 Pages 2017
FTY720 (Fingolimod) reverses α-synuclein-induced downregulation of brain-derived neurotrophic factor mRNA in OLN-93 oligodendroglial cells Fulltext Access 9 Pages 2017
Galanin (1-15) enhancement of the behavioral effects of Fluoxetine in the forced swimming test gives a new therapeutic strategy against depression Fulltext Access 9 Pages 2017
Expression of the K+/Clâ cotransporter, KCC2, in cerebellar Purkinje cells is regulated by group-I metabotropic glutamate receptors Fulltext Access 9 Pages 2017
Metabotropic glutamate receptor, mGlu5, mediates enhancements of hippocampal long-term potentiation after environmental enrichment in young and old mice Fulltext Access 9 Pages 2017
Chronic citalopram administration desensitizes prefrontal cortex but not somatodendritic α2-adrenoceptors in rat brain Fulltext Access 9 Pages 2017
Relief learning requires a coincident activation of dopamine D1 and NMDA receptors within the nucleus accumbens Fulltext Access 9 Pages 2017
Neuroprotection by Paeoniflorin in the MPTP mouse model of Parkinson's disease Fulltext Access 9 Pages 2017
Trafficking of calcium-permeable and calcium-impermeable AMPA receptors in nucleus accumbens medium spiny neurons co-cultured with prefrontal cortex neurons Fulltext Access 9 Pages 2017