Memantine reduces the production of amyloid-β peptides through modulation of amyloid precursor protein trafficking Fulltext Access 10 Pages 2017
Rapid selection for resistance to diamide insecticides in Plutella xylostella via specific amino acid polymorphisms in the ryanodine receptor Fulltext Access 10 Pages 2017
Alanine to valine substitutions in the pore helix IIIP1 and linker-helix IIIL45 confer cockroach sodium channel resistance to DDT and pyrethroids Fulltext Access 10 Pages 2017
Cadmium-induced IL-6 and IL-8 expression and release from astrocytes are mediated by MAPK and NF-κB pathways Fulltext Access 10 Pages 2017
Hyperammonemia compromises glutamate metabolism and reduces BDNF in the rat hippocampus Fulltext Access 10 Pages 2017
The involvement of autophagy and cytoskeletal regulation in TDCIPP-induced SH-SY5Y cell differentiation Fulltext Access 10 Pages 2017
Effects of perinatal bisphenol A exposure on the volume of sexually-dimorphic nuclei of juvenile rats: A CLARITY-BPA consortium study Fulltext Access 10 Pages 2017
Epigallocatechin-3-gallate prevents cardiac apoptosis by modulating the intrinsic apoptotic pathway in isoproterenol-induced myocardial infarction Fulltext Access 10 Pages 2017
Anti-excitotoxic effects of cannabidiol are partly mediated by enhancement of NCX2 and NCX3 expression in animal model of cerebral ischemia Fulltext Access 10 Pages 2017
MC37, a new mono-carbonyl curcumin analog, induces G2/M cell cycle arrest and mitochondria-mediated apoptosis in human colorectal cancer cells Fulltext Access 10 Pages 2017
Cyclosporine counteracts endotoxemia-evoked reductions in blood pressure and cardiac autonomic dysfunction via central sGC/MAPKs signaling in rats Fulltext Access 10 Pages 2017
Celastrol attenuates angiotensin II mediated human umbilical vein endothelial cells damage through activation of Nrf2/ERK1/2/Nox2 signal pathway Fulltext Access 10 Pages 2017
Tris (1,3-dichloro-2-propyl) phosphate-induced apoptotic signaling pathways in SH-SY5Y neuroblastoma cells Fulltext Access 10 Pages 2017
Paeonol alleviates epirubicin-induced renal injury in mice by regulating Nrf2 and NF-κB pathways Fulltext Access 10 Pages 2017
Propofol attenuates pancreatic cancer malignant potential via inhibition of NMDA receptor Fulltext Access 10 Pages 2017
Identification of demethylincisterol A3 as a selective inhibitor of protein tyrosine phosphatase Shp2 Fulltext Access 10 Pages 2017
Terpenoids as anti-colon cancer agents - A comprehensive review on its mechanistic perspectives Fulltext Access 10 Pages 2017
Butein induction of HO-1 by p38 MAPK/Nrf2 pathway in adipocytes attenuates high-fat diet induced adipose hypertrophy in mice Fulltext Access 10 Pages 2017
Effects of iron overload, an iron chelator and a T-Type calcium channel blocker on cardiac mitochondrial biogenesis and mitochondrial dynamics in thalassemic mice Fulltext Access 10 Pages 2017
Diethyl-4,4ʹ-dihydroxy-8,3ʹ-neolign-7,7ʹ-dien-9,9ʹ-dionate exhibits antihypertensive activity in rats through increase in intracellular cGMP level and blockade of calcium channels Fulltext Access 10 Pages 2017
Dopamine D2 receptors mediate the increase in reinstatement of the conditioned rewarding effects of cocaine induced by acute social defeat Fulltext Access 10 Pages 2017
B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor Fulltext Access 10 Pages 2017
Derivatives of furanditerpenes from Pterodon genus: Pharmacological studies disclose their potential as chronic pain relief in mice Fulltext Access 10 Pages 2017
Matrine attenuates cardiac fibrosis by affecting ATF6 signaling pathway in diabetic cardiomyopathy Fulltext Access 10 Pages 2017
Effects of rehabilitation training on apoptosis of nerve cells and the recovery of neural and motor functions in rats with ischemic stroke through the PI3K/Akt and Nrf2/ARE signaling pathways Fulltext Access 10 Pages 2017
A screen for modulators reveals that orexin-A rapidly stimulates thyrotropin releasing hormone expression and release in hypothalamic cell culture Fulltext Access 10 Pages 2017
Effect of amyloid-Î (25-35) in hyperglycemic and hyperinsulinemic rats, effects on phosphorylation and O-GlcNAcylation of tau protein Fulltext Access 10 Pages 2017
Combine effect of Chondroitinase ABC and low level laser (660Â nm) on spinal cord injury model in adult male rats Fulltext Access 10 Pages 2017
Involvement of GABAA receptors in the regulation of social preference and emotional behaviors by oxytocin in the central amygdala of female mandarin voles Fulltext Access 10 Pages 2017
Hypothalamic pathways regulate the anorectic action of p-chloro-diphenyl diselenide in rats Fulltext Access 10 Pages 2017
Drug induces depression-like phenotypes and alters gene expression profiles in Drosophila Fulltext Access 10 Pages 2017
Characterization of aromatase expression in the spinal cord of an animal model of familial ALS Fulltext Access 10 Pages 2017
Functions of AT1 and AT2 angiotensin receptors in the paraventricular nucleus of the rat, correlating single-unit and cardiovascular responses Fulltext Access 10 Pages 2017
Ceftriaxone reverses deficits of behavior and neurogenesis in an MPTP-induced rat model of Parkinson's disease dementia Fulltext Access 10 Pages 2017
ReviewLong non-coding RNAs in brain development, synaptic biology, and Alzheimer's disease Fulltext Access 10 Pages 2017
Research reportNMDA receptor adjusted co-administration of ecstasy and cannabinoid receptor-1 agonist in the amygdala via stimulation of BDNF/Trk-B/CREB pathway in adult male rats Fulltext Access 10 Pages 2017
Wavy multistratified amacrine cells in the monkey retina contain immunoreactive secretoneurin Fulltext Access 10 Pages 2017
Research reportPrelimbic α1-adrenoceptors are involved in the regulation of depressive-like behaviors in the hemiparkinsonian rats Fulltext Access 10 Pages 2017
Central TrkB blockade attenuates ICV angiotensin II-hypertension and sympathetic nerve activity in male Sprague-Dawley rats Fulltext Access 10 Pages 2017
Supplementation action with ascorbic acid in the morphology of the muscular layer and reactive acetylcholinesterase neurons of ileum of mdx mice Fulltext Access 10 Pages 2017
Renal denervation enhances GABA-ergic input into the PVN leading to blood pressure lowering in chronic kidney disease Fulltext Access 10 Pages 2017
Does MAOA increase susceptibility to prenatal stress in young children? Fulltext Access 10 Pages 2017
Aminoguanidine alleviated MMA-induced impairment of cognitive ability in rats by downregulating oxidative stress and inflammatory reaction Fulltext Access 10 Pages 2017
27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells Fulltext Access 10 Pages 2017
Behavioral effects and neuroanatomical targets of acute atrazine exposure in the male Sprague-Dawley rat Fulltext Access 10 Pages 2017
Gestational exposure to perfluorooctanoic acid (PFOA): Alterations in motor related behaviors Fulltext Access 10 Pages 2017
Reprint of: Importins in the maintenance and lineage commitment of ES cells Fulltext Access 10 Pages 2017
Dencichine ameliorates kidney injury in induced type II diabetic nephropathy via the TGF-β/Smad signalling pathway Fulltext Access 10 Pages 2017
Regulation of allergic airway inflammation by adoptive transfer of CD4+ T cells preferentially producing IL-10 Fulltext Access 10 Pages 2017
Genipin protects d-galactosamine and lipopolysaccharide-induced hepatic injury through suppression of the necroptosis-mediated inflammasome signaling Fulltext Access 10 Pages 2017
PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts Fulltext Access 10 Pages 2017
Selective p300 inhibitor C646 inhibited HPV E6-E7 genes, altered glucose metabolism and induced apoptosis in cervical cancer cells Fulltext Access 10 Pages 2017
Penehyclidine hydrochloride preconditioning provides cardiac protection in a rat model of myocardial ischemia/reperfusion injury via the mechanism of mitochondrial dynamics mechanism Fulltext Access 10 Pages 2017
Inhibition of lipolysis by ilexgenin A via AMPK activation contributes to the prevention of hepatic insulin resistance Fulltext Access 10 Pages 2017
Rutin alleviates diabetic cardiomyopathy and improves cardiac function in diabetic ApoEknockout mice Fulltext Access 10 Pages 2017
Silicon containing ibuprofen derivatives with antioxidant and anti-inflammatory activities: An in vivo and in silico study Fulltext Access 10 Pages 2017
Involvement of cyclic nucleotide-gated channels in spontaneous activity generated in isolated interstitial cells of Cajal from the rabbit urethra Fulltext Access 10 Pages 2017
5-HT7 receptor antagonism (SB-269970) attenuates bleomycin-induced pulmonary fibrosis in rats via downregulating oxidative burden and inflammatory cascades and ameliorating collagen deposition: Comparison to terguride Fulltext Access 10 Pages 2017
14-O-Methylmorphine: A Novel Selective Mu-Opioid Receptor Agonist with High Efficacy and Affinity Fulltext Access 10 Pages 2017
Ionic mechanisms of the action of anaesthetics on sinoatrial node automaticity Fulltext Access 10 Pages 2017
Attenuated diuresis and natriuresis in response to glucagon-like peptide-1 in hypertensive rats are associated with lower expression of the glucagon-like peptide-1 receptor in the renal vasculature Fulltext Access 10 Pages 2017
Genistein, a dietary soy isoflavone, exerts antidepressant-like effects in mice: Involvement of serotonergic system Fulltext Access 10 Pages 2017
Individual and interactive sex-specific effects of acute restraint and systemic IFN-γ treatment on neurochemistry Fulltext Access 10 Pages 2017
Enhanced dopaminergic neurotoxicity mediated by MPTP in IL-32β transgenic mice Fulltext Access 10 Pages 2017
Capillarisin augments anti-oxidative and anti-inflammatory responses by activating Nrf2/HO-1 signaling Fulltext Access 10 Pages 2017
Endothelin causes transactivation of the EGFR and HER2 in non-small cell lung cancer cells Fulltext Access 10 Pages 2017
Research articleIrisin in goldfish (Carassius auratus): Effects of irisin injections on feeding behavior and expression of appetite regulators, uncoupling proteins and lipoprotein lipase, and fasting-induced changes in FNDC5 expression Fulltext Access 10 Pages 2017
Trifluoroacetylated tyrosine-rich D-tetrapeptides have potent antioxidant activity Fulltext Access 10 Pages 2017
The anti-tumor effects of the recombinant toxin protein rLj-RGD3 from Lampetra japonica on pancreatic carcinoma Panc-1 cells in nude mice Fulltext Access 10 Pages 2017
Characterization of two peptides isolated from the venom of social wasp Chartergellus communis (Hymenoptera: Vespidae): Influence of multiple alanine residues and C-terminal amidation on biological effects Fulltext Access 10 Pages 2017
Research paperA novel vascular-targeting peptide for gastric cancer delivers low-dose TNFα to normalize the blood vessels and improve the anti-cancer efficiency of 5-fluorouracil Fulltext Access 10 Pages 2017
Neurochemical and neuropharmacological characterization of ASP2905, a novel potent selective inhibitor of the potassium channel KCNH3 Fulltext Access 10 Pages 2017
Psoralidin, a prenylated coumestan, as a novel anti-osteoporosis candidate to enhance bone formation of osteoblasts and decrease bone resorption of osteoclasts Fulltext Access 10 Pages 2017
Morin activates the Nrf2-ARE pathway and reduces oxidative stress-induced DNA damage in pancreatic beta cells Fulltext Access 10 Pages 2017
Force development and intracellular Ca2+ in intact cardiac muscles from gravin mutant mice Fulltext Access 10 Pages 2017
Remote limb ischemic post conditioning during early reperfusion alleviates cerebral ischemic reperfusion injury via GSK-3β/CREB/ BDNF pathway Fulltext Access 10 Pages 2017
In vivo pharmacological profile of S 38093, a novel histamine H3 receptor inverse agonist Fulltext Access 10 Pages 2017
Selective cytotoxicity of the antibacterial peptide ABP-dHC-Cecropin A and its analog towards leukemia cells Fulltext Access 10 Pages 2017
Epigallocatechin-3-gallate ameliorates hypoxia-induced pulmonary vascular remodeling by promoting mitofusin-2-mediated mitochondrial fusion Fulltext Access 10 Pages 2017
Magnesium isoglycyrrhizinate blocks fructose-induced hepatic NF-κB/NLRP3 inflammasome activation and lipid metabolism disorder Fulltext Access 10 Pages 2017
Liraglutide, a glucagon-like peptide-1 analog, induce autophagy and senescence in HepG2 cells Fulltext Access 10 Pages 2017
APD668, a G protein-coupled receptor 119 agonist improves fat tolerance and attenuates fatty liver in high-trans fat diet induced steatohepatitis model in C57BL/6 mice Fulltext Access 11 Pages 2017
Oleanolic acid modulates the renin-angiotensin system and cardiac natriuretic hormone concomitantly with volume and pressure balance in rats Fulltext Access 11 Pages 2017
Cyclooxygenase-2 inhibitors differentially attenuate pentylenetetrazol-induced seizures and increase of pro- and anti-inflammatory cytokine levels in the cerebral cortex and hippocampus of mice Fulltext Access 11 Pages 2017
Role of mitochondrial dysfunction in renal fibrosis promoted by hypochlorite-modified albumin in a remnant kidney model and protective effects of antioxidant peptide SS-31 Fulltext Access 11 Pages 2017
Interaction among hERG channel blockers is a potential mechanism of death in caffeine overdose Fulltext Access 11 Pages 2017
Salidroside protects rat liver against ischemia/reperfusion injury by regulating the GSK-3β/Nrf2-dependent antioxidant response and mitochondrial permeability transition Fulltext Access 11 Pages 2017
Direct activation of Ca2+ and voltage-gated potassium channels of large conductance by anandamide in endothelial cells does not support the presence of endothelial atypical cannabinoid receptor Fulltext Access 11 Pages 2017
Celastrol attenuates mitochondrial dysfunction and inflammation in palmitate-mediated insulin resistance in C3A hepatocytes Fulltext Access 11 Pages 2017
Anfibatide protects against rat cerebral ischemia/reperfusion injury via TLR4/JNK/caspase-3 pathway Fulltext Access 11 Pages 2017
Effects of BMS-902483, an α7 nicotinic acetylcholine receptor partial agonist, on cognition and sensory gating in relation to receptor occupancy in rodents Fulltext Access 11 Pages 2017
In vitro and in vivo antitumor activities of T-3764518, a novel and orally available small molecule stearoyl-CoA desaturase 1 inhibitor Fulltext Access 11 Pages 2017
Simultaneous blockade of NMDA receptors and PARP-1 activity synergistically alleviate immunoexcitotoxicity and bioenergetics in 3-nitropropionic acid intoxicated mice: Evidences from memantine and 3-aminobenzamide interventions Fulltext Access 11 Pages 2017
The selective effect of glycyrrhizin and glycyrrhetinic acid on topoisomerase IIα and apoptosis in combination with etoposide on triple negative breast cancer MDA-MB-231 cells Fulltext Access 11 Pages 2017
In vitro and in vivo pharmacology of NXT629, a novel and selective PPARα antagonist Fulltext Access 11 Pages 2017
New opioid receptor antagonist: Naltrexone-14-O-sulfate synthesis and pharmacology Fulltext Access 11 Pages 2017