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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Recent advances in metal catalyzed intramolecular aryl additions-accessing bioactive molecules
Fulltext Access 8 Pages 2016
Modular genetic regulatory networks increase organization during pattern formation
Fulltext Access 8 Pages 2016
Using epigenetic networks for the analysis of movement associated with levodopa therapy for Parkinson's disease
Fulltext Access 8 Pages 2016
Artificial intelligence and synthetic biology: A tri-temporal contribution
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The body of knowledge: On the role of the living body in grounding embodied cognition
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Stochastic analysis of Chemical Reaction Networks using Linear Noise Approximation
Fulltext Access 8 Pages 2016
A novel azo-thiourea based visible light switchable anion receptor
Fulltext Access 8 Pages 2016
An efficient synthesis of phosphoramidates from halides in aqueous ethanol
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The reductive cleavage of picolinic amides
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Tritylation of alcohols under mild conditions without using silver salts
Fulltext Access 8 Pages 2016
Phenomic prediction of maize hybrids
Fulltext Access 8 Pages 2016
Synthesis of ladder-type graphene ribbon oligomers from pyrene units
Fulltext Access 8 Pages 2016
Ecofriendly syntheses of phenothiazones and related structures facilitated by laccase - a comparative study
Fulltext Access 8 Pages 2016
Use of 'click chemistry' for the synthesis of carbohydrate-porphyrin dendrimers and their multivalent approach toward lectin sensing
Fulltext Access 8 Pages 2016
Synthesis of new benzimidazolium salts and their application in the asymmetric arylation of aldehydes
Fulltext Access 8 Pages 2016
Conversion of aziridines to oxazolidines through geminal difunctionalization of vinyl arenes or by tandem ring-opening/closing reaction of aziridine itself
Fulltext Access 8 Pages 2016
LiCl-mediated, easy, and low-cost removal of the trityl group from protected alcohols and diols
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Zinc oxide surface: a versatile nanoplatform for solvent-free synthesis of diverse isatin derivatives
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Metal-free, Brønsted acid-mediated synthesis of coumarin derivatives from phenols and propiolic acids
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Synthesis and Diels-Alder reactions of novel styrylcyclohexenol dienes: a general pathway for the synthesis of tricyclic lactone and octahydronaphthalene systems
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Thermodynamic investigation of the interaction between cyclodextrins and preservatives - Application and verification in a mathematical model to determine the needed preservative surplus in aqueous cyclodextrin formulations
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Extensions of indication throughout the drug product lifecycle: a quantitative analysis
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Immunotoxin therapy for hematologic malignancies: where are we heading?
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Intracellular transport of nanocarriers across the intestinal epithelium
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Developing timely insights into comparative effectiveness research with a text-mining pipeline
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Exploration of individuality in drug metabolism by high-throughput metabolomics: The fast line for personalized medicine
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Identifying compound efficacy targets in phenotypic drug discovery
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Developing genetically engineered mouse models using engineered nucleases: Current status, challenges, and the way forward
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Systems pharmacology of hepatic metabolism in zebrafish larvae
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Systematical bifurcation analysis of an intracellular calcium oscillation model
Fulltext Access 8 Pages 2016
Synthesis and characterization of two fluorenone-based conjugated polymers and their application in solar cells and thin film transistors
Fulltext Access 8 Pages 2016
Process design and control of a twin screw hot melt extrusion for continuous pharmaceutical tamper-resistant tablet production
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Mechanism study on stability enhancement of adefovir dipivoxil by cocrystallization: Degradation kinetics and structure-stability correlation
Fulltext Access 8 Pages 2016
Lipid based noninvasive vesicular formulation of cytarabine: Nanodeformable liposomes
Fulltext Access 8 Pages 2016
Formulation and stabilization of norfloxacin in liposomal preparations
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Evaluation of the artificial membrane permeability of drugs by digital simulation
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Leverage nonclinical development of bispecifics by translational science
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Translational pharmacologyTranslational biomarkers: from discovery and development to clinical practice
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Engineered miniaturized models of musculoskeletal diseases
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Transparency in drug regulation: public assessment reports in Europe and Australia
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Current therapies for premature ejaculation
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Overview of the synthesis of carbazoloquinone natural products
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Applying lessons learned from cytomegalovirus infection in transplant patients to vaccine design
Fulltext Access 8 Pages 2016
Locoregional cancer therapy using polymer-based drug depots
Fulltext Access 8 Pages 2016
Molecular targets of quercetin with anti-inflammatory properties in atopic dermatitis
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Drugs affecting glycosaminoglycan metabolism
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Water, water, everywhere… It's time to stop and think
Fulltext Access 8 Pages 2016
Targeting delivery in Parkinson's disease
Fulltext Access 8 Pages 2016
Computational power and generative capacity of genetic systems
Fulltext Access 8 Pages 2016
The use of cyclooxygenase-2 inhibitors for improvement of efficacy of radiotherapy in cancers
Fulltext Access 9 Pages 2016
Organization principles of biological networks: An explorative study
Fulltext Access 9 Pages 2016
Synthesis of the first representatives of amino bis(picolyl) and amino bis(quinaldinyl) phosphines
Fulltext Access 9 Pages 2016
Optimisation of the synthesis of second generation 1,2,4,5 tetraoxane antimalarials
Fulltext Access 9 Pages 2016
On the behavior of bis(sulfonyl)nitrobutadienes towards primary amines: a convenient access to 1-alkyl-2-aryl-4-(phenylsulfonyl)pyrroles
Fulltext Access 9 Pages 2016
Synthesis of 2-(2-hydroxyaryl)alkenylphosphonium salts from phosphine oxides via ring-closing ring-opening approach and their antimicrobial evaluation
Fulltext Access 9 Pages 2016
Synthesis and structural studies of new asymmetric pyridyl-tetrazole ligands for supramolecular chemistry
Fulltext Access 9 Pages 2016
Exploration of structural motifs influencing solid-state conformation and packing of unclosed cryptands sharing the same 19-membered macrocyclic core
Fulltext Access 9 Pages 2016
Quantitative systems pharmacology: a promising approach for translational pharmacology
Fulltext Access 9 Pages 2016
Translational pharmacokinetics and pharmacodynamics of monoclonal antibodies
Fulltext Access 9 Pages 2016
Volatile constituents and antimicrobial activities of nine South African liverwort species
Fulltext Access 9 Pages 2016
Natural polyphenols: potential in the prevention of sexually transmitted viral infections
Fulltext Access 9 Pages 2016
Translatability: what does it mean in drug discovery?
Fulltext Access 9 Pages 2016
Mapping lifecycle management activities for blockbuster drugs in Japan based on drug approvals and patent term extensions
Fulltext Access 9 Pages 2016
A multiple information fusion method for predicting subcellular locations of two different types of bacterial protein simultaneously
Fulltext Access 9 Pages 2016
Hexavalent glycoclusters having tris-bipyridine ferrous complex cores as minimum combinatorial libraries for probing carbohydrate-carbohydrate interactions
Fulltext Access 9 Pages 2016
Habitat variability does not generally promote metabolic network modularity in flies and mammals
Fulltext Access 9 Pages 2016
Design principles for clinical network-based proteomics
Fulltext Access 9 Pages 2016
Modeling approaches for hepatic spatial heterogeneity in pharmacokinetic simulations
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Self-assembly drug conjugates for anticancer treatment
Fulltext Access 9 Pages 2016
Assessment of cognitive safety in clinical drug development
Fulltext Access 9 Pages 2016
A comprehensive company database analysis of biological assay variability
Fulltext Access 9 Pages 2016
Synthesis and evaluation of functionalized benzoboroxoles as potential anti-tuberculosis agents
Fulltext Access 9 Pages 2016
Naphthol-based macrocyclic receptors
Fulltext Access 9 Pages 2016
Rearrangement of 4-oxobutane-1,1,2,2-tetracarbonitriles to the penta-1,3-diene-1,1,3-tricarbonitrile moiety as an approach to novel acceptors for donor-acceptor chromophores
Fulltext Access 9 Pages 2016
Recent advances in dual transition metal-visible light photoredox catalysis
Fulltext Access 9 Pages 2016
Pyrrole acetylenecarbaldehydes: an entry to a novel class of functionalized pyrroles
Fulltext Access 9 Pages 2016
Are enzymes sensitive to the multivalent effect? Emerging evidence with glycosidases
Fulltext Access 9 Pages 2016
Microwave-assisted synthesis of new fluorescent indoline-based building blocks by ligand free Suzuki-Miyaura cross-coupling reaction in aqueous media
Fulltext Access 9 Pages 2016
Alternative tandem cyclisation pathways in the reaction between imines and enones
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One-pot multicomponent synthesis of highly substituted bicyclo[2.2.2]octane derivatives using bismuth nitrate as a catalyst
Fulltext Access 9 Pages 2016
Pyridinium saccharinate salts as efficient recyclable acylation catalyst: a new bridge between heterogeneous and homogeneous catalysis
Fulltext Access 9 Pages 2016
Neuropharmacology beyond reductionism - A likely prospect
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Design and synthesis of diaziridinyl quinone thiadiazole hybrids via nitrile sulfide cycloaddition reaction as a key step
Fulltext Access 9 Pages 2016
Facile synthesis of hexahydropyrazino[2,3-e]pyrazines from 3-aminomethyl-1,2,4-triazoles
Fulltext Access 9 Pages 2016
Synthesis and conformational study of novel pyrazine-based pseudopeptides bearing amidoxime, amidoxime ester and 1,2,4-oxadiazole units
Fulltext Access 9 Pages 2016
Self-assembly of cyclic peptides and peptidomimetic macrocycles: linking structure with function
Fulltext Access 9 Pages 2016
Ketenimine mediated synthesis of lactam iminosugars: development of one-pot process via tandem hydrative amidation of amino-alkynes and intramolecular transamidation
Fulltext Access 9 Pages 2016
Lanthanide and asymmetric catalyzed syntheses of sterically hindered 4-isoxazolyl-1,4-dihydropyridines and 4-isoxazolyl-quinolones
Fulltext Access 9 Pages 2016
Recent advances in aerobic oxidation with ruthenium catalysts
Fulltext Access 9 Pages 2016
Synthetic studies pertaining to the 2,3-pyridyne and 4,5-pyrimidyne
Fulltext Access 9 Pages 2016
Mechanistic insights into a catalyst-free method to construct quinazolinones through multiple oxidative cyclization
Fulltext Access 9 Pages 2016
Ring-opening reaction of aziridines with amines under the influence of dimethyl sulfoxide
Fulltext Access 9 Pages 2016
The 1,3-dioxane motif-a useful tool in monitoring molecular and supramolecular architectures
Fulltext Access 9 Pages 2016
Reactions of ethyl cyanoformate with cycloimmonium salts: a direct pathway to fused or substituted azaheterocycles
Fulltext Access 9 Pages 2016
Protonated trititanate nanotubes: an efficient catalyst for one-pot three-component coupling of benzothiazole amines, heterocyclic aldehydes, and dialkyl/diaryl phosphites with a greener perspective
Fulltext Access 9 Pages 2016
Aromatization of pyridinylidenes into pyridines is inhibited by exocyclic delocalization. A theoretical mechanistic assessment
Fulltext Access 9 Pages 2016
Quantum formalism as an optimisation procedure of information flows for physical and biological systems
Fulltext Access 9 Pages 2016
Networks and games for precision medicine
Fulltext Access 9 Pages 2016
Synthesis of purine nucleoside-amino acid conjugates and their photophysical properties
Fulltext Access 9 Pages 2016
Analyzing resilience properties in oscillatory biological systems using parametric model checking
Fulltext Access 9 Pages 2016
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