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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Evaluation of ion exchange processes in drug-eluting embolization beads by use of an improved flow-through elution method
Fulltext Access 9 Pages 2016
Design, synthesis and biological evaluation of novel non-covalent piperidine-containing peptidyl proteasome inhibitors
Fulltext Access 9 Pages 2016
Synthesis and biological evaluation of novel pyrazolopyrimidines derivatives as anticancer and anti-5-lipoxygenase agents
Fulltext Access 9 Pages 2016
Novel analogs of alloferon: Synthesis, conformational studies, pro-apoptotic and antiviral activity
Fulltext Access 9 Pages 2016
Optimization of the process variables of tilianin-loaded composite phospholipid liposomes based on response surface-central composite design and pharmacokinetic study
Fulltext Access 9 Pages 2016
Pharmacokinetics/pharmacodynamic correlations of fluconazole in murine model of cryptococcosis
Fulltext Access 9 Pages 2016
Modulating lipophilicity of rohitukine via prodrug approach: Preparation, characterization, and in vitro enzymatic hydrolysis in biorelevant media
Fulltext Access 9 Pages 2016
Pharmacokinetics and pharmacodynamics evaluation of a thermosensitive chitosan based hydrogel containing liposomal doxorubicin
Fulltext Access 9 Pages 2016
Evaluation of the route dependency of the pharmacokinetics and neuro-pharmacokinetics of tramadol and its main metabolites in rats
Fulltext Access 9 Pages 2016
Dual functioning microspheres embedded crosslinked gelatin cryogels for therapeutic intervention in osteomyelitis and associated bone loss
Fulltext Access 9 Pages 2016
Effectiveness of supersaturation promoting excipients on albendazole concentrations in upper gastrointestinal lumen of fasted healthy adults
Fulltext Access 9 Pages 2016
Applicability of near-infrared spectroscopy in the monitoring of film coating and curing process of the prolonged release coated pellets
Fulltext Access 9 Pages 2016
Pharmacokinetic modeling of a gel-delivered dapivirine microbicide in humans
Fulltext Access 9 Pages 2016
Synthesis and evaluation of dihydropyrimidinone-derived selenoesters as multi-targeted directed compounds against Alzheimer's disease
Fulltext Access 9 Pages 2016
Experimental and in silico investigations of organic phosphates and phosphonates sorption on polymer-ceramic monolithic materials and hydroxyapatite
Fulltext Access 9 Pages 2016
Influence of salivary washout on drug delivery to the oral cavity using coated microneedles: An in vitro evaluation
Fulltext Access 9 Pages 2016
Effects of cisplatin and letrozole on surgically induced endometriosis and comparison of the two medications in a rat model
Fulltext Access 9 Pages 2016
Molecularly imprinted microparticles in lipid-based formulations for sustained release of donepezil
Fulltext Access 9 Pages 2016
Solubility, lipophilicity and membrane permeability of some fluoroquinolone antimicrobials
Fulltext Access 9 Pages 2016
Usefulness of minipigs for predicting human pharmacokinetics: Prediction of distribution volume and plasma clearance
Fulltext Access 9 Pages 2016
Developments of mass spectrometry-based technologies for effective drug development linked with clinical proteomes
Fulltext Access 9 Pages 2016
Improving drug safety with a systems pharmacology approach
Fulltext Access 9 Pages 2016
Development of oral site-specific pellets containing flavonoid extract with antioxidant activity
Fulltext Access 9 Pages 2016
Formulation and evaluation of chitosan/polyethylene oxide nanofibers loaded with metronidazole for local infections
Fulltext Access 9 Pages 2016
Feasibility of a trial with Tibetan Singing Bowls, and suggested benefits in metastatic cancer patients. A pilot study in an Italian Oncology Unit
Fulltext Access 9 Pages 2016
Design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2
Fulltext Access 9 Pages 2016
Synthesis and bioactivity of novel triazole incorporated benzothiazinone derivatives as antitubercular and antioxidant agent
Fulltext Access 9 Pages 2016
Synthesis, biological evaluation and structure-activity relationship of 2-styrylquinazolones as anti-tubercular agents
Fulltext Access 9 Pages 2016
Design, synthesis and biological evaluation of pyrazolylaminoquinazoline derivatives as highly potent pan-fibroblast growth factor receptor inhibitors
Fulltext Access 9 Pages 2016
Isolation, analytical measurements, and cell line studies of the iron-bryostatin-1 complex
Fulltext Access 9 Pages 2016
Strigolactone derivatives for potential crop enhancement applications
Fulltext Access 9 Pages 2016
Design, synthesis and structure-activity relationship of novel diphenylamine derivatives
Fulltext Access 9 Pages 2016
Tubulin modulating antifungal and antiproliferative pyrazinone derivatives
Fulltext Access 9 Pages 2016
Combined dual effect of modulation of human neutrophils' oxidative burst and inhibition of colon cancer cells proliferation by hydroxycinnamic acid derivatives
Fulltext Access 9 Pages 2016
Exploring new chemical functionalities to improve aromatase inhibition of steroids
Fulltext Access 9 Pages 2016
Multi-walled nanotubes for cellular reprogramming of cancer
Fulltext Access 9 Pages 2016
Magnetic sentinel lymph node biopsy in a murine tumour model
Fulltext Access 9 Pages 2016
Identifying distinct nanoscopic features of native collagen fibrils towards early diagnosis of pelvic organ prolapse
Fulltext Access 9 Pages 2016
Comparison of individualized virtual reality- and group-based rehabilitation in older adults with chronic stroke in community settings: a pilot randomized controlled trial
Fulltext Access 9 Pages 2016
Graphical contents list
Fulltext Access 9 Pages 2016
Design, synthesis and antiproliferative activity of novel 5-nitropyrimidine-2,4-diamine derivatives bearing alkyl acetate moiety
Fulltext Access 9 Pages 2016
Synthesis, characterization and in vitro evaluation of amphiphilic ion pairs of erythromycin and kanamycin antibiotics with liposaccharides
Fulltext Access 9 Pages 2016
Tyrosol and hydroxytyrosol derivatives as antitrypanosomal and antileishmanial agents
Fulltext Access 9 Pages 2016
Graphical contents list
Fulltext Access 9 Pages 2016
Polyvalent effect enhances diglycosidic antiplasmodial activity
Fulltext Access 9 Pages 2016
Challenges of docking in large, flexible and promiscuous binding sites
Fulltext Access 9 Pages 2016
General van der Waals potential for common organic molecules
Fulltext Access 9 Pages 2016
Expedient synthesis of an atypical oxazolidinone compound library
Fulltext Access 9 Pages 2016
Novel approach of fragment-based lead discovery applied to renin inhibitors
Fulltext Access 9 Pages 2016
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers
Fulltext Access 9 Pages 2016
Multiantigenic peptide–polymer conjugates as therapeutic vaccines against cervical cancer
Fulltext Access 9 Pages 2016
Graphical contents list
Fulltext Access 9 Pages 2016
Synthesis and antimicrobial activity of styryl/pyrrolyl/pyrazolyl sulfonylmethyl-1,3,4-oxadiazolyl amines and styryl/pyrrolyl/pyrazolyl sulfonylmethyl-1,3,4-thiadiazolyl amines
Fulltext Access 9 Pages 2016
Synthesis, anti-cancer evaluation of benzenesulfonamide derivatives as potent tubulin-targeting agents
Fulltext Access 9 Pages 2016
Synthesis and biological evaluation of new naphthalene substituted thiosemicarbazone derivatives as potent antifungal and anticancer agents
Fulltext Access 9 Pages 2016
Synthesis, characterization and biological evaluation of benzothiazoles and tetrahydrobenzothiazoles bearing urea or thiourea moieties as vasorelaxants and inhibitors of the insulin releasing process
Fulltext Access 9 Pages 2016
Emerging therapeutics for the treatment of diabetic nephropathy
Fulltext Access 9 Pages 2016
Syntheses and biological evaluation of 1,2,3-triazole and 1,3,4-oxadiazole derivatives of imatinib
Fulltext Access 9 Pages 2016
Structural features underlying raloxifene’s biophysical interaction with bone matrix
Fulltext Access 9 Pages 2016
Expanding the structural diversity of diarylureas as multi-target tyrosine kinase inhibitors
Fulltext Access 9 Pages 2016
Synthesis and biological evaluation of novel 5-hydroxylaminoisoxazole derivatives as lipoxygenase inhibitors and metabolism enhancing agents
Fulltext Access 9 Pages 2016
Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies
Fulltext Access 9 Pages 2016
Design, synthesis, and biological evaluation of arylpiperazine–benzylpiperidines with dual serotonin and norepinephrine reuptake inhibitory activities
Fulltext Access 9 Pages 2016
Protective effects of kaempferol against reactive oxygen species-induced hemolysis and its antiproliferative activity on human cancer cells
Fulltext Access 9 Pages 2016
Simple and accurate single base resolution analysis of 5-hydroxymethylcytosine by catalytic oxidative bisulfite sequencing using micelle incarcerated oxidants
Fulltext Access 9 Pages 2016
Design, synthesis, and mode of action studies of a mitomycin tetramer inducing double activations with a single probe
Fulltext Access 9 Pages 2016
Heptapeptide ligands against receptor-binding sites of influenza hemagglutinin toward anti-influenza therapy
Fulltext Access 9 Pages 2016
A spectroscopic study of substituted anthranilic acids as sensitive environmental probes for detecting cancer cells
Fulltext Access 9 Pages 2016
Design and synthesis of a new generation of substituted purine hydroxamate analogs as histone deacetylase inhibitors
Fulltext Access 9 Pages 2016
Synthesis and anti-acetylcholinesterase activity of scopoletin derivatives
Fulltext Access 9 Pages 2016
A photo-cleavable biotin affinity tag for the facile release of a photo-crosslinked carbohydrate-binding protein
Fulltext Access 9 Pages 2016
Identification of novel acetylcholinesterase inhibitors: Indolopyrazoline derivatives and molecular docking studies
Fulltext Access 9 Pages 2016
Syntheses and odor properties of optically active dimethyl octenone and its analogs
Fulltext Access 9 Pages 2016
Total synthesis of panaxydol and its stereoisomers as potential anticancer agents
Fulltext Access 9 Pages 2016
Synthesis of organotin derivatives of optically active eleven-membered macrodiolides
Fulltext Access 9 Pages 2016
Effect of pirfenidone delivered using layer-by-layer thin film on excisional wound healing
Fulltext Access 9 Pages 2016
The prevalence of traditional and complementary medicine in the general population in Kashan, Iran, 2014
Fulltext Access 9 Pages 2016
A formulation of grape seed, Indian gooseberry, turmeric and fenugreek helps controlling type 2 diabetes mellitus in advanced-stage patients
Fulltext Access 9 Pages 2016
Women and complementary medicine: Eleven years of experience at a homeopathic clinic for women in a public hospital
Fulltext Access 9 Pages 2016
Preparation of fluorous Yamaguchi reagents and evaluation of their reactivity in esterification
Fulltext Access 9 Pages 2016
Insights into the diastereoselective control in the sulfa-Michael addition of thiols to nitroalkenes: stereoelectronic effect in the cyclic chelated transition state
Fulltext Access 9 Pages 2016
2-Heteroarylidene-1-indanone derivatives as inhibitors of monoamine oxidase
Fulltext Access 9 Pages 2016
Stereochemistry abstracts
Fulltext Access 9 Pages 2016
Dual action of acertannins as potential regulators of intracellular ceramide levels
Fulltext Access 9 Pages 2016
Spherical polymeric nanoconstructs for combined chemotherapeutic and anti-inflammatory therapies
Fulltext Access 9 Pages 2016
Multiscale benchmarking of drug delivery vectors
Fulltext Access 9 Pages 2016
Co-administration of morphine and gabapentin leads to dose dependent synergistic effects in a rat model of postoperative pain
Fulltext Access 9 Pages 2016
Nanonized itraconazole powders for extemporary oral suspensions: Role of formulation components studied by a mixture design
Fulltext Access 9 Pages 2016
Biocompatibility assessment of fibrous nanomaterials in mammalian embryos
Fulltext Access 9 Pages 2016
Fundamental understanding of drug absorption from a parenteral oil depot
Fulltext Access 9 Pages 2016
Effects of ramp-up of inspired airflow on in vitro aerosol dose delivery performance for certain dry powder inhalers
Fulltext Access 9 Pages 2016
Chitosan-pectin hybrid nanoparticles prepared by coating and blending techniques
Fulltext Access 9 Pages 2016
Synthesis and characterization of a novel radioiodinated phenylacetamide and its homolog as theranostic agents for malignant melanoma
Fulltext Access 9 Pages 2016
Olanzapine modulation of hepatic oxidative stress and inflammation in socially isolated rats
Fulltext Access 9 Pages 2016
The molecular assembly of the ionic liquid/aliphatic carboxylic acid/aliphatic amine as effective and safety transdermal permeation enhancers
Fulltext Access 9 Pages 2016
Uptake of free, calcium-bound and liposomal encapsulated nitrogen containing bisphosphonates by breast cancer cells
Fulltext Access 9 Pages 2016
Co-spray dried resveratrol and budesonide inhalation formulation for reducing inflammation and oxidative stress in rat alveolar macrophages
Fulltext Access 9 Pages 2016
A supersaturating delivery system of silibinin exhibiting high payload achieved by amorphous nano-complexation with chitosan
Fulltext Access 9 Pages 2016
Real-time monitoring of cocrystallization processes by solvent evaporation: A near infrared study
Fulltext Access 9 Pages 2016
Synthesis and biological evaluation of salicylic acid conjugated isoxazoline analogues on immune cell proliferation and angiogenesis
Fulltext Access 9 Pages 2016
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