دانلود مقالات ISI درباره Α-Syn + ترجمه فارسی

The effect of fluorescent labeling on α-synuclein fibril morphology

Keywords: α-syn; α-synuclein; AFM; atomic force microscopy; WT; wild type; A140C α-syn; α-syn substitution mutant with residue 140 mutated from Alanine to Cysteine; PD; Parkinson's disease; ThT; thioflavin T; EM; electron microscopy; EDTA; ethylenediaminetetraa

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2016 سفارش ترجمه

Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice

Keywords: α-Syn; α-Synuclein; AD; Alzheimer's disease; APP; amyloid precursor protein; BBB; blood-brain barrier; DAB; 3,3′-Diaminobenzidine tetrahydrochloride; DFO; deferoxamine; DMEM; Dulbecco's minimum essential medium; DMSO; dimethyl sulfoxide; DMT1; dival

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2016 سفارش ترجمه

Proteasome subunit and opioid receptor gene expression down-regulation induced by paraquat and maneb in human neuroblastoma SH-SY5Y cells

Keywords: PQ; paraquat; MB; maneb; α-syn; α-synuclein; TH; tyrosine hydroxylase; PD; Parkinson's disease; SN; substantia nigra; UPS; ubiquitin-proteasome 26 S system; CP; core particle; RP; regulatory particle; Rpt; regulatory particle triphosphateses; Rpn; reg

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Blood α-synuclein in agricultural pesticide handlers in central Washington State

Keywords: AChE; acetylcholinesterase; α-Syn; α-synuclein; BuChE; butyrylcholinesterase; PON1; paraoxonase; PD; Parkinson disease; α-Synuclein; Aryldialkylphosphatase; Chlorpyrifos; Parkinson disease; Pesticides;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

TNF compromises lysosome acidification and reduces α-synuclein degradation via autophagy in dopaminergic cells

Keywords: TNF; tumor necrosis factor-α; PD; Parkinson's disease; α-SYN; α-synuclein; DA; dopamine; CQ; chloroquine; CM; conditioned medium; LPS; lipopolysaccharide; CHX; cycloheximide; 3-MA; 3-methyladenine; tf-LC3; RFP-GFP-tandem fluorescent LC3; TFEB; transcri

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Tea polyphenols alleviate motor impairments, dopaminergic neuronal injury, and cerebral α-synuclein aggregation in MPTP-intoxicated parkinsonian monkeys

Keywords: α-syn; α-synuclein; DA; dopamine; DOPAC; 3,4-dihydroxyphenylacetic acid; EC; (-)-epicatechin; ECG; (-)-epicatechin-3-gallate; EGC; (-)-epigal-locatechin; EGCG; (-)-epigallocatechin-3-gallate; ELISA; Enzyme-Linked Immunosorbnent Assay; HVA; homov

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Molecular chaperones and neuronal proteostasis

Keywords: 17-AAG; 17-allylamino-17-demethoxygeldanamycin; 17-DMAG; 17-dimethylamino-ethylamino-17-demethoxygeldanamycin; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ARSACS; autosomal recessive spastic ataxia of Charlevoix-Saguena

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils

Keywords: α-syn; α-synuclein; PD; Parkinson's disease; Aβ; beta amyloid; LBs; Lewy bodies; LNs; Lewy neuritis; Gn; ginsenoside; GST; glutathione S-transferase; IPTG; isopropyl β-d-1-thiogalactopyranoside; DTT; dithiothreitol; SDS; sodium dodecyl sulfate; PBS; p

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Adverse effects of a SOD1-peptide immunotherapy on SOD1G93A mouse slow model of amyotrophic lateral sclerosis

Keywords: ALS; amyotrophic lateral sclerosis; CS; clinical score; ELISA; enzyme-linked immunosorbent assay; FALS; familial amyotrophic lateral sclerosis; GFAP; glial fibrillary acidic protein; Iba-1; ionized calcium binding adaptor molecule; IgG; immunoglobulin G;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Basic NeuroscienceReviewα-Synuclein and nonhuman primate models of Parkinson's disease

Keywords: α-syn; α-synuclein; 6-OHDA; 6-hydroxydopamine; AAV2; adeno-associated viral vector serotype 2/2; ALP; autophagy-lysosomal pathway; BBB; blood-brain-barrier; c-hGH; cadaver-derived human growth hormone; CK; casein kinases; DA; dopamine; DAT; dopamine

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Protein misfolding cyclic amplification (PMCA): Current status and future directions

Keywords: TSEs; transmissible spongiform encephalopathies; PrPTSE; disease associated misfolded PrP; PrPC; cellular prion protein; PrPres; proteinase K resistant misfolded PrP; PrP27-30; proteinase K resistant core of misfolded PrP; rPrP; recombinant PrP; PMCA; p

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Research ReportSquamosamide derivative FLZ protected dopaminergic neuron by activating Akt signaling pathway in 6-OHDA-induced in vivo and in vitro Parkinson's disease models

Keywords: PD; Parkinson's disease; PI3K; phosphoinositide-3-kinase; α-Syn; α-synuclein; 6-OHDA; 6-hydroxydopamine; TH; tyrosine hydroxylase; Co-IP; Co-Immunoprecipitation; FLZ; Parkinson's disease; Akt; α-synuclein; Tyrosine hydroxylase;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: Targets for disease modification?

Keywords: Aβ; amyloid beta; AD; Alzheimer's disease; Akt; protein kinase B; α-syn; α-synuclein; BAD; Bcl-2 antagonist of death; BBB; blood brain barrier; Bcl-2; B-cell lymphoma 2; Bcl-XL; B-cell lymphoma extra large; Bim; Bcl-2 interacting mediator of death; cAM

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2014 سفارش ترجمه

AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons

Keywords: NH2htau; NH2-human tau fragment of 20-22 kDa; ANT-1; Adenine Nucleotide Translocator-1; AD; Alzheimer's Disease; APP; amyloid precursor protein; Aβ; amyloid beta; PD; Parkinson's disease; α-syn; α-synuclein; FAD; Familiar Alzheimer's Disease; MOI; m

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2014 سفارش ترجمه

Autophagy and apoptosis dysfunction in neurodegenerative disorders

Keywords: AMBRA; activating molecule in Beclin-1-regulated autophagy; AD; Alzheimer's diseases; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; Aβ; amyloid-beta; α-syn; alpha-synuclein; ALS; amyotrophic lateral sclerosis; APP; amyloid beta precursor

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2014 سفارش ترجمه

α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease

Keywords: PD; Parkinson disease; SNPc; substantia nigra pars compacta; α-syn; α-synuclein; GTPCH; GTP cyclohydrolase I; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPP+; 1-methyl-4-phenylpyridinium; NOS; nitric oxide synthase; DAT; dopamine transporter; B

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2014 سفارش ترجمه

Oligodendroglial alpha-synucleinopathy and MSA-like cardiovascular autonomic failure: Experimental evidence

Keywords: PLP; proteolipid protein promoter; MSA; multiple system atrophy; MSA-P; parkinsonian variant of MSA; MSA-C; cerebellar variant of MSA; α-syn; alpha-synuclein; SND; striatonigral degeneration; OPCA; olivopontocerebellar atrophy; GCI; (oligodendro-)glial c

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Genetic analysis of the ATG7 gene promoter in sporadic Parkinson's disease

Keywords: AP2; Activator protein-2; α-Syn; α-syncuclein; ATGs; autophagy-related genes; ATG3; autophagy-related gene 3; ATG7; autophagy-related gene 7; ATG12; autophagy-related gene 12; CREB; cAMP-responsive element binding protein; HNF-1; hepatocyte nuclear fact

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Research ReportRNA interference targeting α-synuclein attenuates methamphetamine-induced neurotoxicity in SH-SY5Y cells

Keywords: METH; methamphetamine; α-syn; α-synuclein; LBs; Lewy bodies; DA; dopamine; TH; tyrosine hydroxylase; DAT; dopamine transporter; VMAT-2; vesicular monoamine transporter 2; ROS; reactive oxygen species; NOS; nitric oxide synthase; NO; nitrogen monoxide; Î

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Surface behavior of α-Synuclein and its interaction with phospholipids using the Langmuir monolayer technique: A comparison between monomeric and fibrillar α-Synuclein

Keywords: α-Syn; alpha Synuclein; ThT; Thioflavine T; DLS; Dynamic Light Scattering; AFM; Atomic Force Microscopy; RH; Hydrodynamic Radius; α-Synuclein; Monomer and fibrillar forms; Monolayer technique;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Pressure-temperature folding landscape in proteins involved in neurodegenerative diseases and cancer

Keywords: ANS; 1-anilino 8-naphthalene sulfonate; α-syn; alpha-synuclein; bis-ANS; 4, 4′-bis(1-anilinonaphthalene 8-sulfonate); DA; dopamine; FTIR; Fourier transform infrared; HHP; high hydrostatic pressure; I state; intermediate state; LB; Lewy bodies; NMR; nuc

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

The sources of salidroside and its targeting for multiple chronic diseases

Keywords: 6-OHDA; 6-hydroxydopamine; Aβ; β-amyloid protein; MPTP; 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine; MPP+; N-methyl-4-phenylpyridine; AD; Alzheimer's disease; PD; Parkinson's disease; STZ; streptozotocin; PI3K; phosphatidylinositol 3-kinase; ROS; react

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2020 سفارش ترجمه

Expression pattern and localization of alpha-synuclein in the human enteric nervous system

Keywords: α-syn; α-synuclein; p-α-syn; phosphorylated α-synuclein; ENS; enteric nervous system; CNS; central nervous system; LB; Lewy bodies; LN; Lewy neurites; LMD; laser microdissection; GI; gastrointestinal; PD; Parkinson´s disease; qPCR; quantitative PCR;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Impaired olfactory bulb neurogenesis depends on the presence of human wild-type alpha-synuclein

Keywords: α-syn; alpha-synuclein; BrdU; 5-bromo-2′-deoxyuridine; CaM_α-syn; human wild-type alpha-synuclein transgenic mice; CaM_α-syn + dox; human wild-type alpha-synuclein transgenic mice plus treatment with doxycycline; CaMKII; calcium/calmodulin-dependen

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse

Keywords: α-syn; α-synuclein; ASK1; Apoptosis signaling-regulating kinase 1; CMA; Chaperone-mediated autophagy; DAT; Dopamine transporter; ETC; Electron transport chain; iPS; Induced pluripotent stem; LAMP-2A; Lysosome-associated membrane protein 2A; LB; Lewy bod

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2012 سفارش ترجمه

Neuromuscular pathology in mice lacking alpha-synuclein

Keywords: α-syn; alpha-synuclein; ACh; acetylcholine; CMAP; compound muscle action potential; R-CMAP; repetitive compound muscle action potential; Alpha-synuclein; Skeletal muscles; Neuromuscular junction; Electromyography; Knockout mice;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Synuclein modulation of monoamine transporters

Keywords: α-Syn; α-synuclein; β-Syn; β-synuclein; γ-Syn; γ-synuclein; AD; Alzheimer's disease; CNS; central nervous system; DA; dopamine; DAT; dopamine transporter; DMI; desipramine; MAT; presynaptic plasma membrane monoamine transporters; NAC; non-Aβ comp

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Redox activity of α-synuclein-Cu is silenced by Zn7-metallothionein-3

Keywords: Aβ; amyloid-β; AD; Alzheimer disease; α-Syn; α-synuclein; CC; cluster centered; 3-CCA; coumarin 3-carboxylic acid; CD; circular dichroism; CysS; cysteine thiolate; DEAE; diethylaminoethyl; EPR; electron paramagnetic resonance; ESI-Q-TOF MS; electrospr

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

The KDEL receptor induces autophagy to promote the clearance of neurodegenerative disease-related proteins

Keywords: KDEL receptor; ER stress; neurodegenerative disease-related proteins; autophagy; ALS; amyotrophic lateral sclerosis; ARF1; ADP ribosylation factor 1; ARF1-GAP; ARF1 GTPase-activating protein; ATG5; autophagy-related gene 5; BIP; binding immunoglobulin pro

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Prosurvival effect of human wild-type α-synuclein on MPTP-induced toxicity to central but not peripheral catecholaminergic neurons isolated from transgenic mice

Keywords: α-synuclein transgenic mice; Parkinson's disease; protection against MPTP; nigrostriatal system; peripheral nervous system; α-SYN; alpha-synuclein; DA; dopamine; DAB; 3,3′-diaminobenzidine; DAT; dopamine transporter; DOPAC; 3,4-dihydroxyphenyl acetic

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2010 سفارش ترجمه

Partial regulation of serotonin transporter function by γ-synuclein

Keywords: 5-HT; serotonin; SERT; serotonin transporter; α-Syn; α-synuclein; γ-Syn; γ-synuclein; β-Syn; β-synuclein; co-IP; co-immunoprecipitation; IMP; imipramine; Depression; Mood disorders; Monoamine transporters; γ-Synuclein; Serotonin transporter; Raphe

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Immunolocalization of alpha-synuclein in the rat spinal cord by two novel monoclonal antibodies

Keywords: synucleins; nervous system; immunohistochemistry; spinal cord; Parkinson disease; NPY; neuropeptide tyrosine; PBS; phosphate-buffered saline; PD; Parkinson's disease; SNCA; gene coding for α-synuclein; TH; tyrosine hydroxylase; α-Syn; alpha-synuclein;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Proteomic profiling of phosphoproteins and glycoproteins responsive to wild-type alpha-synuclein accumulation and aggregation

Keywords: ACN; acetonitrile; α-Syn; wild-type alpha-synuclein; AD; Alzheimer's disease; BCA; bicinchoninic acid assay; 2-D; two-dimensional; FA; formic acid; IEF; isoelectric focusing; IMAC; immobilized metal ion affinity chromatography; PAGE; polyacrylamide gel e

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2009 سفارش ترجمه

Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease

Keywords: Neurodegenerative disorders; Parkinson's disease; AD; Alzheimer's disease; DA; dopamine; DA-ergic neurons; dopaminergic neurons; 18F-DOPA; 6-18fluoro-l-dihydroxy phenylalanine; GIRK channel; G-protein-activated inward-rectifying K+ channel; wv/+; heterozy

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه