Long non-coding RNA HOTAIR promotes ischemic infarct induced by hypoxia through up-regulating the expression of NOX2
Keywords: Ischemic infarct; HOTAIR; NOX2; HT22Â cells;
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Role of NOX2 in mediating doxorubicin-induced senescence in human endothelial progenitor cells
Keywords: Endothelial progenitor cells; Aging; Doxorubicin; Nox2; Cardiovascular diseases;
Overexpression of HDAC6 induces pro-inflammatory responses by regulating ROS-MAPK-NF-κB/AP-1 signaling pathways in macrophages
Keywords: HDAC6; histone deacetylase 6; ROS; reactive oxygen species; Nox2; NADPH oxidase enzyme 2; MAPK; mitogen-activated protein kinase; NF-κB; nuclear factor kappa B; AP-1; activator protein-1; ROS; HDAC6; Inflammation; Cytokines; MAPK; NF-κB; AP-1; Macrophag
NADPH oxidase 4 deficiency leads to impaired wound repair and reduced dityrosine-crosslinking, but does not affect myofibroblast formation
Keywords: NADPH oxidase 4; Dityrosine crosslinking; Wound healing; Wound repair; HIF1alpha; CD31; Myofibroblast; Mouse model; Neovascularization; ROS; MPO; NOX2; Collagen crosslinking; Extracellular matrix; NOX4; VPO1; Myeloperoxidase;
Ethanol directly induced HMGB1 release through NOX2/NLRP1 inflammasome in neuronal cells
Keywords: Ethanol; HMGB1 release; NOX2; NLRP1 inflammasome;
Activation of the AGE/RAGE system in the brains of rats and in SH-SY5Y cells exposed to high level of fluoride might connect to oxidative stress
Keywords: AGE/RAGE; Fluorosis; MDA; NOX2; ROS
EHT 1864, a small molecule inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac1), attenuates glucose-stimulated insulin secretion in pancreatic β-cells
Keywords: Arf6; ADP-ribosylation factor 6; Cdc42; Cell division control protein 42; ERK1/2; Extracellular signal-regulated kinases; GEF; Guanine nucleotide exchange factor; GDP; Guanosine diphosphate; GTP; Guanosine triphosphate; GGTI; Geranylgeranyl transferase in
Acute ethanol induces apoptosis by stimulating TRPC6 via elevation of superoxide in oxygenated podocytes
Keywords: Catalase; Oxidative stress; NOX2; Patch-clamp technique; Confocal microscopy; Intracellular Ca2 +
Contractile Function During Angiotensin-IIÂ Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation
Keywords: angiotensin II; contraction; myocyte; NADPH oxidase; Ang II; angiotensin II; [Ca2+]i; intracellular calcium ions; HF; heart failure; LV; left ventricular; NADPH; reduced nicotinamide adenine dinucleotide phosphate; NCX; sodium-calcium exchange; Nox2; NADP
Close teamwork between Nrf2 and peroxiredoxins 1 and 6 for the regulation of prostaglandin D2 and E2 production in macrophages in acute inflammation
Keywords: AA; arachidonic acid; AP-1; activator protein-1; ARE; antioxidant-response element; BMDM; bone marrow-derived macrophage; COX-2; cyclooxygenase-2; DEX; dexamethasone; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; ERK2; extracellular-regulated kinase 2; GST
Curcumin ameliorated diabetic neuropathy partially by inhibition of NADPH oxidase mediating oxidative stress in the spinal cord
Keywords: STZ; streptozotocin; NS; normal saline; NADPH; nicotinamide adenine dinucleotide phosphate; SOD; superoxide dismutase; MDA; malondialdehyde; H2O2; hydrogen peroxide; ROS; reactive oxygen species; NOX2; nicotinamide adenine dinucleotide phosphate oxidase 2
NADPH oxidase inhibition improves neurological outcome in experimental traumatic brain injury
Keywords: Traumatic brain injury; NADPH oxidase; NOX2; Apocynin
MicroRNA-34a induces apoptosis in the human glioma cell line, A172, through enhanced ROS production and NOX2 expression
Keywords: miR-34a; Human glioma cell line A172; Apoptosis; NOX2
Flavonoids promoting HaCaT migration: II. Molecular mechanism of 4′,6,7-trimethoxyisoflavone via NOX2 activation
Keywords: Flavonoids; Wound healing; Keratinocyte; 4′,6,7-Trimethoxyisoflavone (TMF); Migration; NOX2
Remote ischemic preconditioning differentially affects NADPH oxidase isoforms during hepatic ischemia-reperfusion
Keywords: NOX2; NOX4; Microcirculation; Inflammation; Intravital video microscopy; Modified spectrophotometry; Polymorphonuclear leukocytes;
L-alpha-glycerylphosphorylcholine reduces the microcirculatory dysfunction and nicotinamide adenine dinucleotide phosphate-oxidase type 4 induction after partial hepatic ischemia in rats
Keywords: Liver; Ischemia-reperfusion; Microcirculation; Modified spectrometry; HMGB1; TNF-α; Myeloperoxidase; NOX2; NOX4
NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII
Keywords: NOX2; NADPH oxidase 2; gp91phox; catalytic subunit of NOX2; Ang II; Angiotensin II; ROS; Reactive oxygen species; H89; N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamide; SERCA; SR Ca ATPAse; SR; sarcoplasmic reticulum; AIP; autoca
Extra virgin olive oil blunt post-prandial oxidative stress via NOX2 down-regulation
Keywords: Extra virgin olive oil; Oxidative stress; NOX2; Mediterranean diet;
Detection of superoxide production in stimulated and unstimulated living cells using new cyclic nitrone spin traps
Keywords: BMPO; 5-tert-butoxycarbonyl-5-methyl-1-pyrroline N-oxide; CAT; catalase; CD-DIPPMPO; 6-monodeoxy-6-mono-4-[(5-diisopropoxyphosphoryl-5-methyl-1-pyrroline-N-oxide)-ethylenecarbamoyl-(2,3-di-O-methyl)hexakis-(2,3,6-tri-O-methyl)]-β-cyclodextrin; DEPMPO; 5-
Serotonin regulates innate immune responses of colon epithelial cells through Nox2-derived reactive oxygen species
Keywords: 5-HT; Nox2; Innate immune response; Inflammatory bowel disease; Reactive oxygen species; Free radicals;
Nitroxyl (HNO) suppresses vascular Nox2 oxidase activity
Keywords: cGMP; cyclic guanosine monophosphate; cGK; cGMP-dependent protein kinase; IPA/NO; isopropylamine NONOate; MCA; middle cerebral artery; ODQ; 1H-[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one; PDBu; phorbyl 12,13-dibutyrate; ROS; reactive oxygen species; Rp-8-pC
Oxidative stress in atrial fibrillation: An emerging role of NADPH oxidase
Keywords: Oxidative stress; Atrial fibrillation; NADPH oxidase; NOX2; NOX4; Structural and electrical remodeling;
Nitroarachidonic acid prevents NADPH oxidase assembly and superoxide radical production in activated macrophages
Keywords: AA; arachidonic acid; AANO2; nitroarachidonic acid; O2â¢â; superoxide radical; NOX2; phagocytic NADPH oxidase; PMA; phorbol myristate acetate; ROS; reactive oxygen species, RNS, reactive nitrogen species, NOS2, inducible nitric oxide synthase, Cyt c, c
Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide
Keywords: cGMP; guanosine 3â²,5â²-cyclic monophosphate; GTP; guanosine 5â²-triphosphate; pGC; particulate-type guanylyl cyclase; sGC; soluble-type guanylyl cyclase; 8-Nitro-cGMP; 8-nitroguanosine 3â²,5â²-cyclic monophosphate; PTM; post-translational modificati
The sources of salidroside and its targeting for multiple chronic diseases
Keywords: 6-OHDA; 6-hydroxydopamine; Aβ; β-amyloid protein; MPTP; 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine; MPP+; N-methyl-4-phenylpyridine; AD; Alzheimer's disease; PD; Parkinson's disease; STZ; streptozotocin; PI3K; phosphatidylinositol 3-kinase; ROS; react
Ofloxacin induces apoptosis via β1 integrin-EGFR-Rac1-Nox2 pathway in microencapsulated chondrocytes
Keywords: Ofloxacin; Reactive oxygen species; Apoptosis; β1 integrin; Nox2
Protection against vascular aging in Nox2-deficient mice: Impact on endothelial progenitor cells and reparative neovascularization
Keywords: Aging; Angiogenesis; Neovascularization; Nox2; Oxidative stress; EPCs;
Anionic lipid-induced conformational changes in human phagocyte flavocytochrome b precede assembly and activation of the NADPH oxidase complex
Keywords: Cytochrome b558/559; Phosphatidic acid; Neutrophils; Nox2; NOX; Oxidants; Superoxide
Nox4- and Nox2-dependent oxidant production is required for VEGF-induced SERCA cysteine-674 S-glutathiolation and endothelial cell migration
Keywords: SERCA; Endothelial cells; VEGF; Hydrogen peroxide; Calcium; Nox2; Nox4; Free radicals;
Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; CTLA-4; cytotoxic T-lymphocyte antigen 4; FACS; fluorescence-activated cell sorting; Foxp3; forkhead-box transcription factor; GFP; green fluorescent protein; IL-4; interleukin 4; IL-10; interle
Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation
Keywords: Akt; Nox2; Tat; HIV-1; LTR transactivation;
Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke
Keywords: Ang II; angiotensin II; AT1; angiotensin receptor 1; KO; knockout mouse; MCA; middle cerebral artery; MCAO; middle cerebral artery occlusion; NOX1; Nox1-containing NADPH oxidase; NOX2; Nox2-containing NADPH oxidase; NOX4; Nox4-containing NADPH oxidase; rC
Nox regulation of smooth muscle contraction
Keywords: ROS, reactive oxygen species; DPI, diphenylene iodinuim; IR, inverted repeat; PTPs, protein tyrosine phosphatases; VSMCs, vascular smooth muscle cells; Ang II, Angiotensin IINox; Duox; dNox; dDuox; NADPH Oxidase; Reactive Oxygen; Drosophila; Nox1; Nox2; N
A key role for the microglial NADPH oxidase in APP-dependent killing of neurons
Keywords: Alzheimers disease; Amyloid precursor protein; NOX2; NADPH oxidase; Microglia; Neuroblastoma cells