Well-defined biohybrids using reversible-deactivation radical polymerization procedures
Keywords: RDRP; ATRP; RAFT; Bioconjugates; Biohybrids; Polymer
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PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases
Keywords: hNV; human Norovirus; mNV; murine Norovirus; RdRp; RNA-dependent-RNA-polymerase; PDB; Protein Data Bank; PPNDS; Pyridoxal-5â²-phosphate-6-(2â²-naphthylazo-6â²-nitro-4â²,8â²-disulfonate) tetrasodium salt; Norovirus; RNA-dependent-RNA-polymerase; Antiv
Identification and molecular characterization of human antibody fragments specific for dengue NS5 protein
Keywords: DENV; dengue virus; NS; non-structural protein; NS5FL; full-length NS5 protein; MTase; methyltrasferase; RdRp; RNA-dependent RNA polymerase; Fab; antigen-binding fragment; Dengue; NS5; Phage display; Antibody; Cross-reactivity;
RacGTPase-activating protein 1 interacts with hepatitis C virus polymerase NS5B to regulate viral replication
Keywords: CE; cell extract; co-IP; coimmunoprecipitation; DMEM; Dulbecco's modified Eagle's medium; dsRNA; double-stranded RNA; FBS; fetal bovine serum; FFU; focus-forming units; GAP; GTPase activating protein; GFP; green fluorescent protein; HEK; human embryo
Biophysical characterization of sites of host adaptive mutation in the influenza A virus RNA polymerase PB2 RNA-binding domain
Keywords: ATCC; American Type Culture Collection; EMSA; electrophoretic mobility shift assays; FAM; fluorescein amidite; FLuc; firefly luciferase; HEK; human embryonic kidney; NMR; nuclear magnetic resonance; RdRp; RNA-dependent RNA polymerase; RLuc; Renilla lucife
Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity
Keywords: DENV; dengue virus; AQ; amodiaquine; CQ; chloroquine; AQD; amodiaquine derivative; NS; nonstructural protein; WNV; West Nile virus; RdRP; RNA-dependent RNA polymerase; Repurposing antimalarials as dengue antivirals; Chloroquine; Primaquine; Stable replico
The intracellular inhibition of HCV replication represents a novel mechanism of action by the innate immune Lactoferrin protein
Keywords: HCV; Hepatitis C virus; hLF; human Lactoferrin; LF; Lactoferrin; HIV; human immunodeficiency virus; HSV1; herpes simplex virus type 1; CMV; cytomegalovirus; RDRP; RNA-dependent RNA polymerase; NGS; normal goat serum; WGA; wheat germ agglutinin; IPTG; isop
Generic detection of poleroviruses using an RT-PCR assay targeting the RdRp coding sequence
Keywords: Polerovirus; Generic RT-PCR; Species-specific RT-PCR; Luteoviridae; RdRp; Phylogeny;
New Hepatitis C Therapies: The Toolbox, Strategies, and Challenges
Keywords: Direct-Acting Antivirals; Interferon-Free Regimens; Sofosbuvir; Simeprevir; Daclatasvir; DAA; direct-acting antiviral; HCV; hepatitis C virus; HIV; human immunodeficiency virus; HTA; host-targeted agent; IFN; interferon; RdRp; RNA-dependent RNA polymera
Emaravirus-specific degenerate PCR primers allowed the identification of partial RNA-dependent RNA polymerase sequences of Maize red stripe virus and Pigeonpea sterility mosaic virus
Keywords: Emaravirus; RdRp; Degenerate primers; RT-PCR; Sequencing;
Asymmetric packaging of polymerases within vesicular stomatitis virus
Keywords: VSV; RdRP; Polymerase; PALM; STORM; AFM; L protein; P protein; Viral replication;
Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of foot-and-mouth disease virus in host cells
Keywords: FMD; foot-and-Mouth Disease; FMDV; foot-and-mouth disease virus; 3Dpol; 3D polymerase; 5D9; 4-chloro-Nâ²-thieno [2,3-d]pyrimidin-4-ylbenzenesulfonohydrazide; QSPR; quantitative structure-property relationship; RdRp; RNA dependent RNA polymerase; RNA; r
ReviewNS5A inhibitors in the treatment of hepatitis C
Keywords: HCV; hepatitis C virus; DAA; direct acting antiviral; NS; nonstructural; RdRp; RNA-dependent RNA polymerase; IFN; interferon; UTR; untranslated region; IRES; internal ribosome entry site; SVR; sustained virological response; RVR; rapid virologic response;
The RNA-dependent RNA polymerase of Citrus tristeza virus forms oligomers
Keywords: CTV; RdRp; Oligomerization; Protein-protein interaction; Epitope tagging; Coimmunoprecipitation; Yeast-two-hybrid system; Protein expression; Immunoblotting;
A peptide targeted against phosphoprotein and leader RNA interaction inhibits growth of Chandipura virus - An emerging rhabdovirus
Keywords: CHPV; Chandipura virus; le-RNA; Chandipura virus leader (+) RNA; RdRp; RNA dependent RNA polymerase; NMR; nuclear magnetic resonance; TOCSY; total correlation spectroscopy; HPLC; high performance liquid chromatography; ESI-MS; electrospray ionization mass
Inhibitors for the hepatitis C virus RNA polymerase explored by SAR with advanced machine learning methods
Keywords: HTQMVQVXFRQIKW-UHFFFAOYSA-N; GHOSNRCGJFBJIB-UHFFFAOYSA-N; QUWPELVBLLLYGL-UHFFFAOYSA-N; AYBCFPXLXOLPIZ-JIPXPUAJSA-N; DWNLKPNALZNWCU-UHFFFAOYSA-N; UVECAUSNPDCAPG-UHFFFAOYSA-N; NS5B; RdRp; HCV; SAR; HCV-796; RDKit; Random Forest; k Nearest Neighbor Simulated
Picornavirus and enterovirus diversity with associated human diseases
Keywords: UTR; untranslated region; RdRp; RNA dependent RNA polymerase; EMCV; Encephalomyocarditis virus; TMEV; Theiler's murine encephalomyelitis virus; VHEV; Vilyuisk human encephalomyelitis virus; TRV; Thera virus; SAFV; Saffold virus; RT-PCR; real-time revers
Characterization of the chandipura virus leader RNA-phosphoprotein interaction using single tryptophan mutants and its detection in viral infected cells
Keywords: Rhabdoviridae; RNA-protein interaction; Transcription-replication switch; Fluorescence quenching; RNA immunoprecipitation; CHPV; chandipura virus; VSV; vesicular stomatitis virus; MNV; Mononegavirales; P protein; phosphoprotein; CKII; casein kinase II
Genome sequence of SeIV-1, a novel virus from the Iflaviridae family infective to Spodoptera exigua
Keywords: IFV; infectious flacherie virus; IRES; internal ribosome entry site; EST; Expressed Sequence Tags; UTR; untranslated region; RACE; rapid amplification of cDNA ends; qPCR; real time quantitative RT-PCR; RdRp; RNA-dependent RNA polymerase; Spodoptera exigua
Different mechanisms of hepatitis C virus RNA polymerase activation by cyclophilin A and B in vitro
Keywords: BSA; bovine serum albumin; CsA; cyclosporine A; CyP; cyclophilin; DTT; dithiothreitol; E; envelope; EDTA; ethylenediaminetetraacetic acid; GST; glutathione S-transferase; HCV; hepatitis C virus; NS; nonstructural protein; PPI; peptidyl prolyl cis/trans-is
Destabilization of PDK1 by Hsp90 inactivation suppresses hepatitis C virus replication through inhibition of PRK2-mediated viral RNA polymerase phosphorylation
Keywords: Hsp90; heat shock protein 90; HCV; hepatitis C virus; RdRp; RNA-dependent RNA polymerase; 17-DMAG; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin; PDK1; phosphoinositide-dependent kinase-1; PRK2; protein kinase C-related kinase 2; Hsp90 inhibitor;
Research ArticleIn vitro selection and characterization of HCV replicons resistant to multiple non-nucleoside polymerase inhibitors
Keywords: HCV; hepatitis C virus; pegIFN; pegylated interferon; RdRp; RNA-dependent RNA polymerase; NI; nucleoside inhibitor; NNI; non-nucleoside inhibitor; NTP; nucleoside triphosphate; DAA; direct-acting antivirals; PI; protease inhibitor; TCA; thiophene carboxyl
Core protein-mediated 5â²-3â² annealing of the West Nile virus genomic RNA in vitro
Keywords: CS; conserved sequence; DAR; downstream AUG region; DB; dumbbell-like structure; DENV; dengue virus; JEV; Japanese encephalitis virus; ORF; open reading frame; RdRp; RNA-dependent RNA polymerase; sfRNA; subgenomic flavivirus RNA; TBEV; tick-borne encephal
Identification and evaluation of anti Hepatitis C virus phytochemicals from Eclipta alba
Keywords: HCV; Hepatitis C virus; NS5B; non-structural protein 5B of hepatitis C virus; SDS-PAGE; sodium dodecyl sulfate polyacrylamide gel electrophoresis; Poly (rA).(dT)18; polyriboadenylic acid annealed with (oligodeoxythymidylic acid)18; RdRp; RNA-dependant RNA
Genome-wide identification of Dicer-like, Argonaute and RNA-dependent RNA polymerase gene families and their expression analyses in response to viral infection and abiotic stresses in Solanum lycopersicum
Keywords: AGO; Argonaute; CS; chilling stress; CDS; coding DNA sequence; CK; control; DCL; Dicer-like protein; dsRNAs; double-stranded RNAs; DS; drought stress; HS; heat stress; hc-siRNAs; heterochromatic siRNAs; ITAG; International Tomato Annotation Group; miRNAs;
AntiâHepatitis C Virus Drugs in Development
Keywords: Protease Inhibitors; NS5B Inhibitors; NS5A Inhibitors; Host Targeted Anti-Virals; DAA; direct-acting antivirals; EVR; early virologic response; HCV; hepatitis C virus; IL; interleukin; miRNA-122; microRNA-122; NI; nucleos(t)ide inhibitor; NNI; non-nucleos
Mechanism of action of the suppression of influenza virus replication by Ko-Ken Tang through inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway and viral RNP nuclear export
Keywords: CAT; chloramphenicol acetyltransferase; CPE; cytopathic effect; KKT; Ko-Ken Tang; pfu; plaque forming unit; PI3K; phosphatidylinositol 3-kinase; moi; multiplicity of infection; pi; post viral infection; RdRp; RNA-dependent RNA polymerase; RNP; ribonucleop
RNA chaperone activity of the tombusviral p33 replication protein facilitates initiation of RNA synthesis by the viral RdRp in vitro
Keywords: Tomato bushy stunt virus; Replication; RNA chaperone; Duplex unwinding; Plus-strand synthesis; In vitro; RdRp; Virus replicase
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors
Keywords: RNA-dependent RNA polymerase; RdRP; Inhibitor; Poliovirus; HTS; RNA
Complete nucleotide sequences of four dsRNAs associated with a new chrysovirus infecting Aspergillus fumigatus
Keywords: Chrysovirus; dsRNA segments; Aspergillus fumigatus; RdRP
Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infection
Keywords: HCV; hepatitis C virus; ATG5; autophagy-related gene 5; DMV; double membrane vesicle; HCV; Autophagy; ATG5; RdRp; NS5B; siRNA;
HCV Research 20 Years After Discovery: A Summary of the 16th International Symposium on Hepatitis C Virus and Related Viruses
Keywords: apo; apolipoprotein; CTLA-4; cytotoxic T-lymphocyte antigen 4; ER; endoplasmic reticulum; GADD45β; growth arrest and DNA damage-inducible 45β; GRE; GU-rich element; HVR1; hypervariable region 1; IFN; interferon; IL; interleukin; IRF; interferon-regulato
Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants
Keywords: HCV; hepatitis C virus; CPE; cytopathic effect; ER; endoplasmic reticulum; RdRp; RNA dependent RNA polymerase; HCV-JFH1 cell culture; Plaque assay; Cytopathic effect; Adaptive mutations; Human hepatocyte chimeric mice;
Processing of SeMV polyproteins revisited
Keywords: SeMV; Sesbania mosaic virus; ssRNA; single-stranded RNA; ORF; open reading frame; VPg; viral protein genome linked; RdRp; RNA dependent RNA polymerase; CfMV; Cocksfoot mottle virus; SCPMV; Southern cowpea mosaic virus; RYMV; Rice yellow mottle virus; P10;
Regulation of hepatitis C virus replication by the core protein through its interaction with viral RNA polymerase
Keywords: HCV; RNA replication; Core protein; Protein interaction; RdRp; Subgenomic replicon;
3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase
Keywords: HCV; NS5b; rdrp; Gamess; Polymerase; Hepatitis; Inhibitor; Non-nucleoside; Palm; Isoquinoline; 3-Hydroxyisoquinoline; Replicon; Dioxo-benzoisothiazole; Negishi; Suzuki; 2-Aminobenzenesulfonamide; N-tert-Butyl-2-chlorobenzene-sulfonamide; 3-Carbomethoxy-1,
Permutation of the active site of putative RNA-dependent RNA polymerase in a newly identified species of plant alpha-like virus
Keywords: Virus; Evolution; RdRp; Palm sub-domain; Internal permutation; Marafivirus; Tymoviridae; Grapevine; Blackberry;
Identification of novel inhibitors of HCV RNA-dependent RNA polymerase by pharmacophore-based virtual screening and in vitro evaluation
Keywords: HCV NS5B; RdRp; Inhibitors; Binding pocket; Virtual screening
Self-guanylylation of birnavirus VP1 does not require an intact polymerase activity site
Keywords: IBDV; Birnavirus; VP1; Protein priming; Polymerase; Guanylylation; RDRP
Inhibition of Japanese encephalitis virus replication by peptide nucleic acids targeting cis-acting elements on the plus- and minus-strands of viral RNA
Keywords: JEV; Peptide nucleic acids (PNAs); Antisense; RdRp; cis-Acting element
Non-nucleoside inhibitors of the hepatitis C virus NS5B RNA-dependant RNA polymerase: 2-Aryl-3-heteroaryl-1,3-thiazolidin-4-one derivatives
Keywords: HCV; NS5B; RdRp; 4-Thiazolidinones
RNA template-mediated inhibition of hepatitis C virus RNA-dependent RNA polymerase activity
Keywords: Hepatitis C virus; HCV; RNA-dependent RNA polymerase; RdRp; NS5B; RNA template inhibition
Effective inhibition of porcine transmissible gastroenteritis virus replication in ST cells by shRNAs targeting RNA-dependent RNA polymerase gene
Keywords: TGEV; RNA interference (RNAi); Short hairpin RNA (shRNA); RdRp; ST;
Clinical-liver, pancreas, and biliary tractMutation Rate of the Hepatitis C Virus NS5B in Patients Undergoing Treatment With Ribavirin Monotherapy
Keywords: CHC; chronic hepatitis C; PCR; polymerase chain reaction; RdRp; RNA-dependent RNA polymerase; Th1; T-helper cell-1;
Modulation of host metabolism as a target of new antivirals
Keywords: HCV; hepatitis C virus; CH; chronic hepatitis; HCC; hepatocellular carcinoma; IFN; interferon; SVR; sustained virological response; PEG-IFN; pegylated-IFN; GBV-B; GB virus B; uPA-SCID; urokinase plasminogen activator-severe combined immunodeficiency; NS;
A homogeneous, solid-phase assay for hepatitis C virus RNA-dependent RNA polymerase
Keywords: Hepatitis C virus; HCV; RNA-dependent RNA polymerase; RdRp; NS5B; High-throughput screening; Scintillation proximity assay; SPA; Solid-phase assay;
Hepatitis C Virus Core Protein Is a Potent Inhibitor of RNA Silencing-Based Antiviral Response
Keywords: dsRNA; double-stranded RNA; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; IRES; internal ribosome entry site; RdRP; RNA-dependent RNA polymerase; RNAi; RNA interference; siRNA; short interfering RNA;
Kinetics and functional studies on interaction between the replicase proteins of Tomato Bushy Stunt Virus: Requirement of p33:p92 interaction for replicase assembly
Keywords: Virus replication; RdRp; Protein–protein interactions; Surface plasmon resonance; Coimmunoprecipitation assay; Yeast host
Structure and prevalence of replication silencer–3′ terminus RNA interactions in Tombusviridae
Keywords: cis-acting RNA; RNA element; RNA virus; Plant virus; DI RNA; Tomato bushy stunt virus; RNA structure; RdRp; Tombusvirus