Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10129123 | International Journal of Biological Macromolecules | 2018 | 103 Pages |
Abstract
Pullulan is a non-ionic, linear, water-soluble and a neutral polysaccharide. It is composed of α-(1,6) repeated maltotriose units via α-(1,4) glycosidic bond having chemical formula (C6H10O5)n. It shows non-immunogenic, non-toxic, non-carcinogenic and non-mutagenic properties. It is used in food edible coatings, films, as flocculant, foaming agent and adhesive. It may also be used as a carrier for bioactive compounds and a protective packaging for food and pharmaceutical products. Therefore, it is blended with different polymers such as carrageenan, mucilages, chitosan, cellulose, sodium alginate, starch, polyethyleneimine, whey-protein, polyisopropylacrylamide, histone, jeffamine, polyamidoamine, pemulen, hyaluronic acid, polyvinyl alcohol and caboxymethyl cellulose. In this article, a comprehensive overview of combination of pullulan with natural and synthetic polymers and their applications in biomedical field involving drug delivery system, tissue engineering, wound healing and gene therapy, is presented. It also describes the utilization of pullulan based materials in food industry, water treatment and pharmaceutical industry. All the technical scientific issues have been addressed; highlighting the recent advancements.
Keywords
PEICLSMAPIPDTPPOCMCDOXAmaranth protein isolateGPCCMPPTXPLPPheophorbideLcstPheoFDAPLAGDLSSAXSPVAnuclear magnetic resonanceHCCHPCsFood & Drug AdministrationFolic acidHyaluronic acidMRIPolypropylene oxideTemFourier-transform infrared spectroscopyNMRWater treatmentTocopheryl succinateDrug and gene deliveryPhotodynamic therapyLower critical solution temperatureDoxorubicinChondroitin sulphateFT-IRSEMscanning electron microscopeTransmission electron microscopeConfocal microscopyRice starchPAMAMXRDX-ray diffractionsmall angle X-ray ScatteringDynamic Light Scatteringpoly(lactic-co-glycolic acid)PolyamidoaminePolyethyleniminePolyethyleneoxidepolyvinyl alcoholEdible coatingsPulPullulanPEOHepatocellular carcinomaCarboxymethyl cellulosehigh performance liquid chromatographyHPLCGel permeation chromatographyGas chromatography
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Authors
Shazia Tabasum, Aqdas Noreen, Muhammad Farzam Maqsood, Hijab Umar, Nadia Akram, Zill-i-Huma Nazli, Shahzad Ali Shahid Chatha, Khalid Mahmood Zia,