Therapeutic implication of vascular endothelial growth factor receptor-1 (VEGFR-1) targeting in cancer cells and tumor microenvironment by competitive and non-competitive inhibitors

Article ID	Journal	Published Year	Pages	File Type
10137652	Pharmacological Research	2018	51 Pages	PDF

Keywords

PlGF SDF-1 TGFβ ERK ECM IDO IFNγ CXCL Tregs GM-CSF VEGFR M-CSF TAMs Sorafenib: (PubMED CID: 216239)sVEGFR-1 Soluble VEGFR-1 AML C-X-C motif chemokine ligand EGFR ADCC OSCC PI3K LPS Mmps NRP MAPK PKB/AKT Angiogenesis interleukin indoleamine 2,3-dioxygenase Transforming Growth Factor Beta Melanoma NSCLC Non-small cell lung cancer Regulatory T cells MIF placental growth factor Macrophage migration inhibitory factor granulocyte-macrophage colony-stimulating factor stromal cell-derived factor-1 acute lymphoid leukemia acute myeloid leukemia lipopolysaccharide extra-cellular matrix macrophage-colony stimulating factor Macrophages Tumor-associated macrophages Metalloproteases Immune checkpoint inhibitors Neuropilin ALL protein kinase B mitogen-activated protein kinase oral squamous cell carcinoma extracellular signal-regulated kinase Interferon gamma vascular endothelial growth factor receptor-1 vascular endothelial growth factor receptor Epidermal growth factor receptor

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Therapeutic implication of vascular endothelial growth factor receptor-1 (VEGFR-1) targeting in cancer cells and tumor microenvironment by competitive and non-competitive inhibitors

Authors

Pedro Miguel Lacal, Grazia Graziani,