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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Fractal dimension: A complementary diagnostic indicator of osteoporosis to bone mineral density
Fulltext Access 3 Pages 2018
Design, synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents
Fulltext Access 4 Pages 2018
Synthesis of chiral isoindolinones via asymmetric propargylation/lactamization cascade
Fulltext Access 4 Pages 2018
Role of copper in depression. Relationship with ketamine treatment
Fulltext Access 4 Pages 2018
Assessing the role of dopamine in the differential neurotoxicity patterns of methamphetamine, mephedrone, methcathinone and 4-methylmethamphetamine
Fulltext Access 11 Pages 2018
A metal-free three components procedure for the synthesis of perfluoroalkyl substituted amidines
Fulltext Access 3 Pages 2017
Correlation between the cellular metabolism of quercetin and its glucuronide metabolite and oxidative stress in hypertrophied 3T3-L1 adipocytes
Fulltext Access 4 Pages 2017
Covalent diphenylalanine peptide nanotube conjugated to folic acid/magnetic nanoparticles for anti-cancer drug delivery
Fulltext Access 9 Pages 2017
A pragmatic randomised controlled trial of healing therapy in a gastroenterology outpatient setting
Fulltext Access 10 Pages 2017
How tumor growth can be influenced by delayed interactions between cancer cells and the microenvironment?
Fulltext Access 14 Pages 2017
Isatin derivatives with activity against apoptosis-resistant cancer cells
Fulltext Access 3 Pages 2016
Antimicrobial resistance and synergy in herbal medicine
Fulltext Access 6 Pages 2016
The “fate” of polymeric and lipid nanoparticles for brain delivery and targeting: Strategies and mechanism of blood–brain barrier crossing and trafficking into the central nervous system
Fulltext Access 11 Pages 2016
Efficient Suzuki reaction catalyzed by recyclable clay carbapalladacycle nanocomposite in ionic liquid media
Fulltext Access 4 Pages 2015
Synthesis of novel ciprofloxacin analogues and evaluation of their anti-proliferative effect on human cancer cell lines
Fulltext Access 4 Pages 2013
Silver salts as new catalyst for coupling reactions; synthesis of epoxyenynes
Fulltext Access 4 Pages 2019
Radical deoxygenation of tertiary alcohols
Fulltext Access 4 Pages 2019
Novel five-co-ordinate phosphorus systems via oxidative addition of pseudohalogens to organic phosphites
Fulltext Access 4 Pages 2019
Calculation of transition state energies by means of simple quantum mechanical lc-methods
Fulltext Access 4 Pages 2019
1.3-Additionen der nitrone an carbonester der acetylenreihe
Fulltext Access 4 Pages 2019
A new ruthenium-catalyzed cyclopropanation of alkenes using propargylic acetates as a precursor of vinylcarbenoids
Fulltext Access 4 Pages 2019
Magnetic non-equivalence of methylene protons in dissymmetric benzylamines
Fulltext Access 5 Pages 2019
Synthesis of Se-arylmethyl selenoformates by reaction of aluminum arylmethaneselenolates with formates
Fulltext Access 5 Pages 2019
Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors
Fulltext Access 5 Pages 2019
Lipase-catalyzed kinetic resolution of phenylcyclohexanone oxime esters
Fulltext Access 6 Pages 2019
Postproduction Handling and Administration of Protein Pharmaceuticals and Potential Instability Issues
Fulltext Access 7 Pages 2019
An Overview of Pharmaceutical Excipients: Safe or Not Safe?
Fulltext Access 8 Pages 2019
Graphical abstracts
Fulltext Access 9 Pages 2019
Design strategies to address kinetics of drug binding and residence time
Fulltext Access 13 Pages 2019
Using Molecular Simulations to Probe Pharmaceutical Materials
Fulltext Access 20 Pages 2019
Recent developments in sulfone chemistry
Fulltext Access 27 Pages 2019
Novel nano-insulin formulation modulates cytokine secretion and remodeling to accelerate diabetic wound healing
Fulltext Access 28 Pages 2019
How the surface functionalized nanoparticles affect conformation and activity of proteins: Exploring through protein-nanoparticle interactions
Fulltext Access 29 Pages 2019
Pentamethinium salts as ligands for cancer: Sulfated polysaccharide co-receptors as possible therapeutic target
Fulltext Access 31 Pages 2019
Combined delivery of angiopoietin-1 gene and simvastatin mediated by anti-intercellular adhesion molecule-1 antibody-conjugated ternary nanoparticles for acute lung injury therapy
Fulltext Access 32 Pages 2019
1,2,4-Trisubstituted imidazolinones with dual carbonic anhydrase and p38 mitogen-activated protein kinase inhibitory activity
Fulltext Access 32 Pages 2019
Galactosylated chitosan triptolide nanoparticles for overcoming hepatocellular carcinoma: Enhanced therapeutic efficacy, low toxicity, and validated network regulatory mechanisms
Fulltext Access 33 Pages 2019
High-content analysis for mitophagy response to nanoparticles: A potential sensitive biomarker for nanosafety assessment
Fulltext Access 36 Pages 2019
Design and synthesis of new carbohydrate-lithocholic acid conjugates linked via 1,2,3-triazole rings
Fulltext Access 36 Pages 2019
Metal/catalyst/reagent free hydration of alkynes up to gram scale under temperature and pressure controlled condition
Fulltext Access 4 Pages 2018
Novel polyamine-based Histone deacetylases-Lysine demethylase 1 dual binding inhibitors
Fulltext Access 4 Pages 2018
Cytotoxic oligophenols from the rhizome of Wikstroemia indica
Fulltext Access 4 Pages 2018
Enhanced intracellular peptide delivery by multivalent cell-penetrating peptide with bioreducible linkage
Fulltext Access 4 Pages 2018
Unexpected one-step synthesis of 3-benzoyl-2-phenylbenzofurans under Wittig conditions
Fulltext Access 4 Pages 2018
Urea decomposition: Efficient synthesis of pyrroles using the deep eutectic solvent choline chloride/urea
Fulltext Access 4 Pages 2018
Palladium-catalyzed intramolecular vinylarylation of alkene: Access to spirocyclic scaffold
Fulltext Access 4 Pages 2018
Catalyst-free synthesis of 1,2,4,5-tetrasubstituted imidazoles from arylamins, benzonitriles, arylglyoxals, and Meldrum's acid
Fulltext Access 4 Pages 2018
Metal-free oxidative cyclization of 2-amino-benzamides, 2-aminobenzenesulfonamide or 2-(aminomethyl)anilines with primary alcohols for the synthesis of quinazolinones and their analogues
Fulltext Access 4 Pages 2018
Design, synthesis and antifungal evaluation of novel pyrazole carboxamides with diarylamines scaffold as potent succinate dehydrogenase inhibitors
Fulltext Access 4 Pages 2018
Visible-light-mediated cascade difunctionalization/cyclization of alkynoates with acyl chlorides for synthesis of 3-acylcoumarins
Fulltext Access 4 Pages 2018
Synthesis and spectroscopic studies of 3-carbamoylisonicotinic acid derivatives
Fulltext Access 4 Pages 2018
Solvent-free mechanochemical Buchwald-Hartwig amination of aryl chlorides without inert gas protection
Fulltext Access 4 Pages 2018
Strontium-mediated selective protonation of unsaturated linkage of aromatic hydrocarbons and these derivatives
Fulltext Access 4 Pages 2018
A simple and fast-response fluorescent probe for hypochlorite in living cells
Fulltext Access 4 Pages 2018
Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1
Fulltext Access 4 Pages 2018
The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents
Fulltext Access 4 Pages 2018
An expedient access to chromanols via an arginine-mediated cascade cyclisation in water
Fulltext Access 4 Pages 2018
A new multifunctional hydroxytyrosol-clofibrate with hypolipidemic, antioxidant, and hepatoprotective effects
Fulltext Access 4 Pages 2018
Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma
Fulltext Access 4 Pages 2018
Study of the structure-activity relationship of polymyxin analogues
Fulltext Access 4 Pages 2018
Literature
Fulltext Access 4 Pages 2018
Alkylated/aminated nitroimidazoles and nitroimidazole-7-chloroquinoline conjugates: Synthesis and anti-mycobacterial evaluation
Fulltext Access 4 Pages 2018
A new Chlorin formulation promotes efficient photodynamic action in choriocapillaris of rabbit's eyes
Fulltext Access 4 Pages 2018
Design, synthesis and biological evaluation of artemisinin derivatives containing fluorine atoms as anticancer agents
Fulltext Access 4 Pages 2018
Synthesis and anti-staphylococcal activity of novel bacterial topoisomerase inhibitors with a 5-amino-1,3-dioxane linker moiety
Fulltext Access 4 Pages 2018
Development of biotin-retinoid conjugates as chemical probes for analysis of retinoid function
Fulltext Access 4 Pages 2018
Design and synthesis of a fragment set based on twisted bicyclic lactams
Fulltext Access 4 Pages 2018
Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors
Fulltext Access 4 Pages 2018
Application de la reaction d'ulimann a la synthese de diaryles encombres precurseurs de lignanes bis-benzocyclootadieniques
Fulltext Access 4 Pages 2018
Synthesis of unsaturated silyl nitronates via the silylation of conjugated nitroalkenes
Fulltext Access 4 Pages 2018
Understanding health-related properties of bushmint (Hyptis) by pharmacokinetic modelling of intestinal absorption
Fulltext Access 4 Pages 2018
Two new cyclopropane monoterpene epimers from Varthemia iphionoides of Jordanian origin
Fulltext Access 4 Pages 2018
Biosynthetic origin of alkylated decaline-type polyketides and induction of a new metabolite by addition of benzoate in cultured mycobionts of Pyrenula sp.
Fulltext Access 4 Pages 2018
The first phytochemical investigation of Rhododendron websterianum: triterpenoids and their cytotoxic activity
Fulltext Access 4 Pages 2018
Chemical structures and antimutagenic effects of unusual oximes from the peels of Citrus limon
Fulltext Access 4 Pages 2018
Literature
Fulltext Access 4 Pages 2018
Aerobic cascade oxidation of substituted cyclopentane-1,2-diones using metalloporphyrin catalysts
Fulltext Access 4 Pages 2018
Synthesis of new di-anchoring organic sensitizer based on quinoxaline acceptor for dye-sensitized solar cells
Fulltext Access 4 Pages 2018
Pd-catalyzed oxidative homo-coupling of acrylates and aromatic alkenes for the conjugated diene synthesis
Fulltext Access 4 Pages 2018
Reusable rhodium catalyst for the selective transvinylation of sp2-C linked carboxylic acid
Fulltext Access 4 Pages 2018
One-pot synthesis of 2,3-disubstituted benzofurans from 2-chlorophenols using palladium-dihydroxyterphenylphosphine catalyst
Fulltext Access 4 Pages 2018
Direct synthesis of 6-sulfonylated phenanthridines via silver-catalyzed radical sulfonylation-cyclization of 2-isocyanobiphenyls
Fulltext Access 4 Pages 2018
Synthesis and cytotoxicity screening of derivatives of the simplified ecteinascidin pentacyclic skeleton as anticancer agents
Fulltext Access 4 Pages 2018
Total synthesis and biological evaluation of nannocystin analogues modified at the polyketide phenyl moiety
Fulltext Access 4 Pages 2018
An efficient metal catalyst free approach to synthesize 5-(4-(1,2,4,5 tetrazin-3-yl)benzylamino)-5-oxopentanoic acid
Fulltext Access 4 Pages 2018
Cytotoxic quinazoline alkaloids from the seeds of Peganum harmala
Fulltext Access 4 Pages 2018
Asymmetric synthesis of highly functionalized tyrosine derivatives for the construction of bistetrahydroisoquinoline alkaloids
Fulltext Access 4 Pages 2018
Synthesis and peripheral substituent effects of bay-annulated indigo derivatives
Fulltext Access 4 Pages 2018
Copper-catalyzed hydroboration of alkenyl oxindoles
Fulltext Access 4 Pages 2018
Facile room-temperature assembly of the 1,2,4-oxadiazole core from readily available amidoximes and carboxylic acids
Fulltext Access 4 Pages 2018
Se-mediated one-pot synthesis of 2-substituted benzoselenazole derivatives from 2 to iodoanilines and arylacetic acids/arylmethyl chlorides
Fulltext Access 4 Pages 2018
Metal-free synthesis of 1,2-amino alcohols by one-pot olefin aziridination and acid ring-opening
Fulltext Access 4 Pages 2018
One-pot synthesis of hydrazine derivatives from aldehydes via radical addition reactions
Fulltext Access 4 Pages 2018
Merging photoredox catalysis with allylboration. The photochemical perfluoroalkylation of unsaturated potassium alkyltrifluoroborates and synthesis of fluorinated alcohols
Fulltext Access 4 Pages 2018
Highly efficient organic photosensitizer with aggregation-induced emission for imaging-guided photodynamic ablation of cancer cells
Fulltext Access 4 Pages 2018
Ruthenium-catalyzed nitrogen-directed ortho CH borylation of aromatic imines with pinacolborane
Fulltext Access 4 Pages 2018
Regioselective oxidative ring-opening of cyclopropenyl carboxylates by visible light photoredox catalysis
Fulltext Access 4 Pages 2018
Synthesis of [6]helicene-based sulfonic acid, sulfonamide, and disulfonimides
Fulltext Access 4 Pages 2018
Fluorescent sensor for fluoride anion based on a sulfonamido-chromone scaffold
Fulltext Access 4 Pages 2018
Nitro-Mannich reaction and intramolecular 1,3-dipolar cycloaddition route to acylpyrrolidinones: Synthesis of a tetramic acid and (+)-laccarin
Fulltext Access 4 Pages 2018
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