Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10591288 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
A series of twenty two novel 1-cyclopropyl-6-fluoro-4-oxo-7-(4-substituted piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid analogues have been synthesized, characterized (1H NMR, 13C NMR and LCMS) and evaluated for their inhibitory activity on the proliferation of human caucasian acute lymphoblastic leukemia cells (CCRF-CEM), breast adenocarcinoma cells (MDA-MB-468) and human colon carcinoma cells (HCT-116). Among all the synthesized ciprofloxacin analogues 3t at 50 μM showed comparable potency to doxorubicin (10 μM) in all three cell lines and 3j inhibited proliferation of MDA-MB-468 up to 35% selectively over other two cell lines.
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Authors
Narva Suresh, Hunsur Nagendra Nagesh, Kondapalli Venkata Gowri Chandra Sekhar, Anil Kumar, Amir N. Shirazi, Keykavous Parang,