| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1358562 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
The objective of this study was to develop a positron emission tomography (PET) probe with hypoxia targeting specificity and a relatively long half-life. The synthesis, 64Cu-labeling in vitro and in vivo study of the novel 2-nitroimidazole complex 64Cu-BMS2P2 is presented in this study. The hypoxia targeting capacity of 64Cu-BMS2P2 in vitro was evaluated and compared with the 64Cu-BMS181321, and confirmed by PET imaging in vivo and immunohistochemistry for carbonic anhydrase 9 (CA9) in a tumor mouse model. These results suggest that 64Cu-BMS2P2 is a promising candidate for PET hypoxia imaging and worthy of further investigations in dynamic hypoxia imaging.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zheng Luo, Hua Zhu, Xinfeng Lin, Taiwei Chu, Ruyi Luo, Yunhua Wang, Zhi Yang,