Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1368501 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
Protein geranylgeranylation is a type of post-translational modification that aids in the localization of proteins to the plasma member where they elicit cellular signals. To better understand the isoprenoid requirements of GGTase-I, a series of aryl-modified geranylgeranyl diphosphate analogs were synthesized and screened against mammalian GGTase-I. Of our seven-member library of compounds, six analogs proved to be substrates of GGTase-I, with 6d having a krel = 1.93 when compared to GGPP (krel = 1.0).
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kayla J. Temple, Elia N. Wright, Carol A. Fierke, Richard A. Gibbs,