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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Silver-catalyzed [3+2+1] annulation of aryl amidines with benzyl isocyanide
Fulltext Access 4 Pages 2018
Impact of mantra meditation on health and wellbeing: A systematic review protocol
Fulltext Access 4 Pages 2018
Un accompagnement sur mesure
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Traitement et prophylaxie du paludisme en pratique
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Adapter et expliquer les traitements de la polyarthrite rhumatoïde
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Information et parcours de soins du patient après chirurgie de la cataracte
Fulltext Access 4 Pages 2018
Is preclinical data sharing the new norm?
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Oxidative kinetic resolution of heterocyclic sulfoxides with a porphyrin-inspired manganese complex by hydrogen peroxide
Fulltext Access 4 Pages 2018
Iridium-catalyzed carbonyl group-directed oxidative coupling of arenes with alkenes
Fulltext Access 4 Pages 2018
Lipase-mediated selective acetylation of primary alcohols in ethyl acetate
Fulltext Access 4 Pages 2018
Iodide catalyzed synthesis of 2-aminobenzoxazoles via oxidative cyclodesulfurization of phenolic thioureas with hydrogen peroxide
Fulltext Access 4 Pages 2018
Pinacol rearrangement of cyclopent-3-en-1,2-diols: Cyclopentenone formation and interrupting reaction
Fulltext Access 4 Pages 2018
Synthesis of biotinylated diazinon: Lessons learned for biotinylation of thiophosphate esters
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Health services research as a framework for expanding a whole systems research agenda in complementary and integrative medicine: The example of intestinal permeability
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Visible-light-activated selective synthesis of sulfoxides via thiol-ene/oxidation reaction cascade
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Transition-metal-free synthesis of aromatic amines via the reaction of benzynes with isocyanates
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Daucus carota root enzyme catalyzed Henry reaction: A green approach
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Novel tricyclic diamines 2. Synthesis of 1,7-diazaisoadamantane, 1,5-diazaisoadamantane and 1,6-diazahomobrendane
Fulltext Access 4 Pages 2018
Synthesis, structure, and host-guest properties of an anthracene-based macrocyclic arene
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Practical selective monohydrolysis of bulky symmetric diesters
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A six-step synthetic approach to marine natural product (+)-aureol
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Identification of the new chymotrypsin inhibitor micropeptin 996 by metabolomics-guided analysis
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A comparative study using conventional methods, ionic liquids, microwave irradiation and combinations thereof for the synthesis of 5-trifluoroacetyl-1,2,3,4-tetrahydropyridines
Fulltext Access 4 Pages 2018
Catalyst-free Petasis-type reaction: Three-component decarboxylative coupling of boronic acids with proline and salicylaldehyde for the synthesis of alkylaminophenols
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Understanding the tetrazole ring cleavage reaction with hydrazines: Structural determination and mechanistic insight
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Hypothesis for the cause and therapy of neurodegenerative diseases
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Affections rhumatologiques du pied
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Synthesis of dihydrobenzoxazine pyrrolidone spirocyclic compounds
Fulltext Access 4 Pages 2018
Literature
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Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma
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A new multifunctional hydroxytyrosol-clofibrate with hypolipidemic, antioxidant, and hepatoprotective effects
Fulltext Access 4 Pages 2018
Design, synthesis and antifungal evaluation of novel pyrazole carboxamides with diarylamines scaffold as potent succinate dehydrogenase inhibitors
Fulltext Access 4 Pages 2018
Reactivity of spiroanthraceneoxazolidines with cyclopropanes: An approach to the oxindole alkaloid scaffold
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Palladium(0)-catalyzed rearrangement of allyl enol ethers to form chiral quaternary carbon centers via asymmetric allylic alkylation
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Discriminating three biothiols by using one fluorescent probe
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Synthesis of a novel bicyclic scaffold inspired by the antifungal natural product sordarin
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Cerebral ischemia: Celebrating successes, confronting challenges
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Carbon dioxide therapy in hypocapnic respiratory failure
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A new cyano-substituted fluorescamine superior to its original form as a fluorescent probe for amino acid detection
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Nature exposure sufficiency and insufficiency: The benefits of environmental preservation
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Dry eye disease in strabismus patients: Does eye deviation harm ocular surface?
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No incision and tension-free vaginal sling for stress urinary incontinence: The role of knotless barbed suture
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Categorising bone defect hematomas - Enhance early bone healing
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The role of trophoblastic epigenetic reprogrammation in benign tumor cells on malignant progression: A molecular hypothesis
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Human chorionic gonadotropin levels of pregnant women can be an indicator of boys with cryptorchidism
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Out of the box: A psychedelic model to study the creative mind
Fulltext Access 4 Pages 2018
The putative glymphatic signature of chronic fatigue syndrome: A new view on the disease pathogenesis and therapy
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A proposed tandem mechanism for memory storage in neurons involving magnetite and prions
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A plausible causal relationship between the increased use of fentanyl as an obstetric analgesic and the current opioid epidemic in the US
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A Risk- and Science-Based Approach to the Acceptance Sampling Plan Inspection of Protein Parenteral Products
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Two new cyclopropane monoterpene epimers from Varthemia iphionoides of Jordanian origin
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Synthesis of unsaturated silyl nitronates via the silylation of conjugated nitroalkenes
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An efficient metal catalyst free approach to synthesize 5-(4-(1,2,4,5 tetrazin-3-yl)benzylamino)-5-oxopentanoic acid
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Direct synthesis of 6-sulfonylated phenanthridines via silver-catalyzed radical sulfonylation-cyclization of 2-isocyanobiphenyls
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One-pot synthesis of 2,3-disubstituted benzofurans from 2-chlorophenols using palladium-dihydroxyterphenylphosphine catalyst
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Reusable rhodium catalyst for the selective transvinylation of sp2-C linked carboxylic acid
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Pd-catalyzed oxidative homo-coupling of acrylates and aromatic alkenes for the conjugated diene synthesis
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Aerobic cascade oxidation of substituted cyclopentane-1,2-diones using metalloporphyrin catalysts
Fulltext Access 4 Pages 2018
Literature
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Insight into copper-catalyzed decarboxylative thiolation of carboxylic acids in the gas phase
Fulltext Access 4 Pages 2018
Chemical structures and antimutagenic effects of unusual oximes from the peels of Citrus limon
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The first phytochemical investigation of Rhododendron websterianum: triterpenoids and their cytotoxic activity
Fulltext Access 4 Pages 2018
Toward bioluminescence in the near-infrared region: Tuning the emission wavelength of firefly luciferin analogues by allyl substitution
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Cytotoxic quinazoline alkaloids from the seeds of Peganum harmala
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Cytotoxic oligophenols from the rhizome of Wikstroemia indica
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Synthesis of polyozellin, a prolyl oligopeptidase inhibitor, and its structural revision
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Water-soluble polyol-methanofullerenes as mitochondria-targeted antioxidants: Mechanism of action
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Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1
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A new Chlorin formulation promotes efficient photodynamic action in choriocapillaris of rabbit's eyes
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Design, synthesis and biological evaluation of artemisinin derivatives containing fluorine atoms as anticancer agents
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Development of biotin-retinoid conjugates as chemical probes for analysis of retinoid function
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Design and synthesis of a fragment set based on twisted bicyclic lactams
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Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors
Fulltext Access 4 Pages 2018
Decarbonylative radical conjugate addition of aliphatic aldehydes for alkylation of electron-deficient alkenes
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Bioequivalency of Doxycycline Products
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Double amination of 2-fluoroallylic acetates by palladium catalysts
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Structure-fluorescence relationship of push-pull 2-phenylbenzothiazole derivatives designed based on the firefly light-emitter
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Photochemical synthesis of cyclic peptide models from phthalimido acetamides and phthaloyl dipeptide esters
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Dioxygenation of styrenes with molecular oxygen in water
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One-pot synthesis of triazole-fused isoindoles from o-alkynylbenzaldehydes and trimethylsilyl azide
Fulltext Access 4 Pages 2018
First total synthesis of medicinally important 3,4,7-trimethoxy-9,10-dihydrophenanthrene-1,5-diol
Fulltext Access 4 Pages 2018
Urea decomposition: Efficient synthesis of pyrroles using the deep eutectic solvent choline chloride/urea
Fulltext Access 4 Pages 2018
Metal-free oxidative cyclization of 2-amino-benzamides, 2-aminobenzenesulfonamide or 2-(aminomethyl)anilines with primary alcohols for the synthesis of quinazolinones and their analogues
Fulltext Access 4 Pages 2018
Metal/catalyst/reagent free hydration of alkynes up to gram scale under temperature and pressure controlled condition
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Visible-light-mediated cascade difunctionalization/cyclization of alkynoates with acyl chlorides for synthesis of 3-acylcoumarins
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A simple and fast-response fluorescent probe for hypochlorite in living cells
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An expedient access to chromanols via an arginine-mediated cascade cyclisation in water
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Nitro-Mannich reaction and intramolecular 1,3-dipolar cycloaddition route to acylpyrrolidinones: Synthesis of a tetramic acid and (+)-laccarin
Fulltext Access 4 Pages 2018
Synthesis of [6]helicene-based sulfonic acid, sulfonamide, and disulfonimides
Fulltext Access 4 Pages 2018
Regioselective oxidative ring-opening of cyclopropenyl carboxylates by visible light photoredox catalysis
Fulltext Access 4 Pages 2018
Merging photoredox catalysis with allylboration. The photochemical perfluoroalkylation of unsaturated potassium alkyltrifluoroborates and synthesis of fluorinated alcohols
Fulltext Access 4 Pages 2018
One-pot synthesis of hydrazine derivatives from aldehydes via radical addition reactions
Fulltext Access 4 Pages 2018
Metal-free synthesis of 1,2-amino alcohols by one-pot olefin aziridination and acid ring-opening
Fulltext Access 4 Pages 2018
Facile room-temperature assembly of the 1,2,4-oxadiazole core from readily available amidoximes and carboxylic acids
Fulltext Access 4 Pages 2018
Asymmetric synthesis of highly functionalized tyrosine derivatives for the construction of bistetrahydroisoquinoline alkaloids
Fulltext Access 4 Pages 2018
Three new 2-(2-phenylethyl)chromone derivatives from artificial holing agarwood of Aquilaria sinensis
Fulltext Access 5 Pages 2018
Fingerprinting metabolomics in tropical mistletoes: A case study with facultative aluminum-accumulating species
Fulltext Access 5 Pages 2018
Liposome-aided metabolic engineering of tumor surface immunogenicity
Fulltext Access 5 Pages 2018
Asymmetric synthesis and antiviral activity of novel chiral amino-pyrimidine derivatives
Fulltext Access 5 Pages 2018
A direct two-dimensional pressure formulation in molecular dynamics
Fulltext Access 5 Pages 2018
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