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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

A boronate-based ratiometric fluorescent probe for fast selective detection of peroxynitrite
Fulltext Access 5 Pages 2018
Therapeutic effects of isothiocyanate prodrugs on rheumatoid arthritis
Fulltext Access 5 Pages 2018
Diversity oriented synthesis of chromene-xanthene hybrids as anti-breast cancer agents
Fulltext Access 5 Pages 2018
Identification of novel plasminogen activator inhibitor-1 inhibitors with improved oral bioavailability: Structure optimization of N-acylanthranilic acid derivatives
Fulltext Access 5 Pages 2018
Carbazole-containing amides and ureas: Discovery of cryptochrome modulators as antihyperglycemic agents
Fulltext Access 5 Pages 2018
Discovery of selective, orally bioavailable inhibitor of mouse chitotriosidase
Fulltext Access 5 Pages 2018
Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors
Fulltext Access 5 Pages 2018
Acylated iridoid diglycosides from the cultivated endangered ornamental tree Gmelina hainanensis
Fulltext Access 5 Pages 2018
Foliar flavonol concentration in Sclerocarya birrea saplings responds to nutrient fertilisation according to growth-differentiation balance hypothesis
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Facile preparation of 3-substituted 2-quinazolinones via electrogenerated base
Fulltext Access 5 Pages 2018
“On water” cascade synthesis of benzopyranopyrazoles and their macrocycles
Fulltext Access 5 Pages 2018
Research on Liebeskind-Srogl coupling/intramolecular Diels-Alder reaction cascade
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Laccase-catalyzed, aerobic oxidative coupling of 4-substituted urazoles with sodium arylsulfinates: Green and mild procedure for the synthesis of arylsulfonyl triazolidinediones
Fulltext Access 5 Pages 2018
A direct two-dimensional pressure formulation in molecular dynamics
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A comparative study of in vitro antimicrobial, antioxidant and cytotoxic activity of Albizia lebbeck and Acacia nilotica stem bark
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The effect of music on the results of a non-stress test: A non-randomized controlled clinical trial
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Integrative medicine as a change agent of hospital staff: From hospital orderlies to partners in health promotion
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Excessive fetal movements are a sign of fetal compromise which merits further examination
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Fibromyalgia and unexplained widespread pain: The idiopathic cerebrospinal pressure dysregulation hypothesis
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Synthesis and characteristics of sugar-phosphoramidates: A spectroscopic study
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Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity
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Should whole body cryotherapy sessions be differentiated between women and men? A preliminary study on the role of the body thermal resistance
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Synthesis of 1-hydrocarbon substituted cyclopropyl silyl ketones
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A simple boronic acid-based fluorescent probe for selective detection of hydrogen peroxide in solutions and living cells
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Marketing authorisation applications submitted to the European Medicines Agency by small and medium-sized enterprises: an analysis of major objections and their impact on outcomes
Fulltext Access 5 Pages 2018
Synthesis of novel multivalent fluorescent inhibitors with high affinity to prostate cancer and their biological evaluation
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Secondary carbamate linker can facilitate the sustained release of dopamine from brain-targeted prodrug
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Discovery of a quinoline-based phenyl sulfone derivative as an antitrypanosomal agent
Fulltext Access 5 Pages 2018
Nano-chemotherapy using cationic liposome that strategically targets the cell membrane potential of pancreatic cancer cells with negative charge
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Structure-based drug design of 1,3,6-trisubstituted 1,4-diazepan-7-ones as selective human kallikrein 7 inhibitors
Fulltext Access 5 Pages 2018
Bioactivity and structure-activity relationship of cinnamic acid derivatives and its heteroaromatic ring analogues as potential high-efficient acaricides against Psoroptes cuniculi
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Synthesis, antimicrobial activity and acid dissociation constants of methyl 5,5-diphenyl-1-(thiazol-2-yl)pyrrolidine-2-carboxylate derivatives
Fulltext Access 5 Pages 2018
Protein Nanoparticles Promote Microparticle Formation in Intravenous Immunoglobulin Solutions During Freeze-Thawing and Agitation Stresses
Fulltext Access 6 Pages 2018
First protection-free protocol for synthesis of 1-deoxy sugars through glycosyl dithiocarbamate intermediates
Fulltext Access 6 Pages 2018
Concise synthesis of artemisinin from a farnesyl diphosphate analogue
Fulltext Access 6 Pages 2018
Natural resonance theory of chemical reactivity, with illustrative application to intramolecular Claisen rearrangement
Fulltext Access 6 Pages 2018
Activatable fluorescent probes in fluorescence-guided surgery: Practical considerations
Fulltext Access 6 Pages 2018
Comparing the effect of listening to music during hemodialysis and at bedtime on sleep quality of hemodialysis patients: A randomized clinical trial
Fulltext Access 6 Pages 2018
Bioactive isoquinoline alkaloids from Glaucium arabicum
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Impacting Global Health Through Equipment Repurposing: Measurable Progress Through the Accumulation of Many Tiny Victories
Fulltext Access 6 Pages 2018
Predictive Screening Tools Used in High-Concentration Protein Formulation Development
Fulltext Access 6 Pages 2018
When east meets west: Understanding the traditional Chinese medicine diagnoses on insomnia by Western medicine symptomatology
Fulltext Access 6 Pages 2018
Preparation and Quality Evaluation of Salvianolic Acids and Tanshinones Dry Powder Inhalation
Fulltext Access 6 Pages 2018
Muscle testing for lie detection: Grip strength dynamometry is inadequate
Fulltext Access 6 Pages 2018
Nanoparticle-loaded gels for topical delivery of nitrofurazone: Effect of particle size on skin permeation and retention
Fulltext Access 6 Pages 2018
Effect of spray-drying temperature on the formation of flower-like lactose for griseofulvin loading
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Drug-excipient compatibility assessment of solid formulations containing meloxicam
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A comprehensive approach for evaluating charge heterogeneity in biosimilars
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Hemicyanine-linked pyrimidine mimics as solvatochromic fluorophores with visible excitation wavelengths
Fulltext Access 6 Pages 2018
Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs
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Effect of listening to music on anxiety and physiological parameters during coronary angiography: A randomized clinical trial
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One-pot synthesis of dihydroquinazolinethione-based polycyclic system
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Effect of surfactant molecular structure on Progesterone solubilization
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Palladium-catalyzed direct allylation of fluorinated benzothiadiazoles with allyl chlorides
Fulltext Access 6 Pages 2018
Three new sesquiterpene lactones from Carpesium abrotanoides
Fulltext Access 6 Pages 2018
Design, synthesis and biological evaluation of novel 1,2,3-triazole linked coumarinopyrazole conjugates as potent anticholinesterase, anti-5-lipoxygenase, anti-tyrosinase and anti-cancer agents
Fulltext Access 6 Pages 2018
Significant Drying Time Reduction Using Microwave-Assisted Freeze-Drying for a Monoclonal Antibody
Fulltext Access 6 Pages 2018
Synthesis and bioactivities evaluation of l-pyroglutamic acid analogues from natural product lead
Fulltext Access 6 Pages 2018
Improving the carbonic anhydrase inhibition profile of the sulfamoylphenyl pharmacophore by attachment of carbohydrate moieties
Fulltext Access 6 Pages 2018
Taurine as a green bio-organic catalyst for the preparation of bio-active barbituric and thiobarbituric acid derivatives in water media
Fulltext Access 6 Pages 2018
Les cytotoxiques par voie orale
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1,8-Naphthalimide-based highly emissive luminogen with reversible mechanofluorochromism and good cell imaging characteristics
Fulltext Access 6 Pages 2018
Total syntheses of (+)-bernumidine and its unnatural enantiomer
Fulltext Access 6 Pages 2018
Screening one bead one compound libraries against serum using a flow cytometer: Determination of the minimum antibody concentration required for ligand discovery
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Novel carbamate-linked quaternary ammonium lipids containing unsaturated hydrophobic chains for gene delivery
Fulltext Access 6 Pages 2018
A latent green fluorescent styrylcoumarin probe for the selective growth and detection of Gram negative bacteria
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Zonal distribution of neutral aroma components in flue-cured tobacco leaves
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Revisiting Amadori and Heyns synthesis: Critical percentage of acyclic form play the trick in addition to catalyst
Fulltext Access 6 Pages 2018
Addressing subphthalocyanines and subnaphthalocyanines features relevant to fluorescence imaging
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Total synthesis of akuammiline alkaloid (+)-strictamine
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A four step synthesis of violaceic acid
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Facile synthesis of perfluoroalkylated fluorenes via a one-pot two-step three-component process
Fulltext Access 6 Pages 2018
Design, synthesis, and evaluation of l-cystine diamides as l-cystine crystallization inhibitors for cystinuria
Fulltext Access 6 Pages 2018
Mechanofluorochromic behavior of anthracene-based acylhydrazone derivatives
Fulltext Access 6 Pages 2018
Facile construction of trifluoromethyl-azirines via one-pot metal-free Neber reaction
Fulltext Access 6 Pages 2018
A red emissive donor-acceptor fluorophore as protein sensor: Synthesis, characterization and binding study
Fulltext Access 6 Pages 2018
Unravelling the binding mechanism of benproperine with human serum albumin: A docking, fluorometric, and thermodynamic approach
Fulltext Access 6 Pages 2018
Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors
Fulltext Access 6 Pages 2018
Identification of novel allosteric inhibitors of mutant isocitrate dehydrogenase 1 by cross docking-based virtual screening
Fulltext Access 6 Pages 2018
Regioselective and efficient enzymatic synthesis of antimicrobial andrographolide derivatives
Fulltext Access 6 Pages 2018
Identification of 2-thioxoimidazolidin-4-one derivatives as novel noncovalent proteasome and immunoproteasome inhibitors
Fulltext Access 6 Pages 2018
Synthesis, spectroscopic studies and biological evaluation of acridine derivatives: The role of aggregation on the photodynamic efficiency
Fulltext Access 6 Pages 2018
Lysosomes-targeting imaging and anticancer properties of novel bis-naphthalimide derivatives
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Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors
Fulltext Access 6 Pages 2018
Characterization of a helminthosporic acid analog that is a selective agonist of gibberellin receptor
Fulltext Access 6 Pages 2018
Acupuncture for improving gait disturbance in Parkinson's disease: A study protocol for a pilot randomized controlled trial
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Interprofessional undergraduate health sciences students' experiences seeking natural health product information from Canadian vendors as self-described in reflective essays
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Association of adiponectin, ghrelin, and leptin with metabolic syndrome and its metabolic components in Sasang constitutional type
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Exploring community pharmacists' knowledge, perception and experiences towards branded and generic medicines in Kuwait: Highlighting the role of pharmacist
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Development of autotaxin inhibitors: A series of zinc binding triazoles
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1er semestre 2018
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Design, synthesis and cytotoxicity of nitrogen-containing tanshinone derivatives
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Exploration of diphenylalkyloxadiazoles as novel cardiac myosin activator
Fulltext Access 6 Pages 2018
Novel compounds that target lipoprotein lipase and mediate growth arrest in acute lymphoblastic leukemia
Fulltext Access 6 Pages 2018
d-Mannitol-derived novel chiral thioureas: Synthesis and application in asymmetric Henry reactions
Fulltext Access 6 Pages 2018
Development of a new fluorescence ratiometric switch for endogenous hypochlorite detection in monocytes of diabetic subjects by dye release method
Fulltext Access 6 Pages 2018
Application of solid-state early-transition metal clusters as catalysts
Fulltext Access 6 Pages 2018
Synthesis and evaluation of the antibacterial activities of aryl substituted dihydrotriazine derivatives
Fulltext Access 6 Pages 2018
Copper diisobutyl-t-butoxyaluminum hydride: A novel reagent for chemoselective reduction of tertiary amides over esters
Fulltext Access 6 Pages 2018
Chiral iminophosphoranes organocatalyzed asymmetric hydroxylation of 3-substituted oxindoles with oxaziridines
Fulltext Access 6 Pages 2018
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