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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Design, synthesis and cytotoxicity of nitrogen-containing tanshinone derivatives
Fulltext Access 6 Pages 2018
Drug-excipient compatibility assessment of solid formulations containing meloxicam
Fulltext Access 6 Pages 2018
Muscle testing for lie detection: Grip strength dynamometry is inadequate
Fulltext Access 6 Pages 2018
Acupuncture for improving gait disturbance in Parkinson's disease: A study protocol for a pilot randomized controlled trial
Fulltext Access 6 Pages 2018
Association of adiponectin, ghrelin, and leptin with metabolic syndrome and its metabolic components in Sasang constitutional type
Fulltext Access 6 Pages 2018
Anti-retroviral drugs: current state and development in the next decade
Fulltext Access 6 Pages 2018
Drug discovery tomorrow: how to Catapult ourselves into the future
Fulltext Access 6 Pages 2018
Mechanism of nanoparticle-induced hypersensitivity in pigs: complement or not complement?
Fulltext Access 6 Pages 2018
EU decision-making for marketing authorization of advanced therapy medicinal products: a case study
Fulltext Access 6 Pages 2018
Real-world evidence approach to traditional herbal medicinal products
Fulltext Access 6 Pages 2018
Nanoparticle-loaded gels for topical delivery of nitrofurazone: Effect of particle size on skin permeation and retention
Fulltext Access 6 Pages 2018
Development of a new fluorescence ratiometric switch for endogenous hypochlorite detection in monocytes of diabetic subjects by dye release method
Fulltext Access 6 Pages 2018
Application of solid-state early-transition metal clusters as catalysts
Fulltext Access 6 Pages 2018
Copper diisobutyl-t-butoxyaluminum hydride: A novel reagent for chemoselective reduction of tertiary amides over esters
Fulltext Access 6 Pages 2018
Chiral iminophosphoranes organocatalyzed asymmetric hydroxylation of 3-substituted oxindoles with oxaziridines
Fulltext Access 6 Pages 2018
A red emissive donor-acceptor fluorophore as protein sensor: Synthesis, characterization and binding study
Fulltext Access 6 Pages 2018
Revisiting Amadori and Heyns synthesis: Critical percentage of acyclic form play the trick in addition to catalyst
Fulltext Access 6 Pages 2018
Iridium-catalyzed asymmetric hydrogenation of 2-substituted 1,4-benzodioxines
Fulltext Access 6 Pages 2018
Catalyst-free synthesis of 2,3-dihydrobenzofurans through [4+1] cycloaddition of ortho-hydroxyphenylsubstituted para-quinone methides and sulfur ylides
Fulltext Access 6 Pages 2018
Highly regioselective photodimerization of 1,4-dihydropyridines: An efficient synthesis of novel 3,6-diazatetraasteranes
Fulltext Access 6 Pages 2018
Synthesis and bioactivities evaluation of l-pyroglutamic acid analogues from natural product lead
Fulltext Access 6 Pages 2018
Bioactive isoquinoline alkaloids from Glaucium arabicum
Fulltext Access 6 Pages 2018
Non-destructive chemical analysis of a Garcinia mangostana L. (Mangosteen) herbarium voucher specimen
Fulltext Access 6 Pages 2018
Transition metal free large-scale synthesis of aromatic vinyl chlorides from aromatic vinyl carboxylic acids using bleach
Fulltext Access 6 Pages 2018
One-pot synthesis of dihydroquinazolinethione-based polycyclic system
Fulltext Access 6 Pages 2018
Significant Drying Time Reduction Using Microwave-Assisted Freeze-Drying for a Monoclonal Antibody
Fulltext Access 6 Pages 2018
Les cytotoxiques par voie orale
Fulltext Access 6 Pages 2018
Total syntheses of (+)-bernumidine and its unnatural enantiomer
Fulltext Access 6 Pages 2018
Screening one bead one compound libraries against serum using a flow cytometer: Determination of the minimum antibody concentration required for ligand discovery
Fulltext Access 6 Pages 2018
A latent green fluorescent styrylcoumarin probe for the selective growth and detection of Gram negative bacteria
Fulltext Access 6 Pages 2018
Effect of surfactant molecular structure on Progesterone solubilization
Fulltext Access 6 Pages 2018
The protected survivor model: Using resistant successful cognitive aging to identify protection in the very old
Fulltext Access 6 Pages 2018
Dissecting spontaneous cerebrospinal fluid collection
Fulltext Access 6 Pages 2018
A complex systems approach to cancer prevention
Fulltext Access 6 Pages 2018
Medical information security in the era of artificial intelligence
Fulltext Access 6 Pages 2018
The potential use of scaffold-mediated local delivery of bone modulators in accelerated orthodontics: A hypotheses
Fulltext Access 6 Pages 2018
Bone resorption and bone metastasis risk
Fulltext Access 6 Pages 2018
Predictive Screening Tools Used in High-Concentration Protein Formulation Development
Fulltext Access 6 Pages 2018
Protein Nanoparticles Promote Microparticle Formation in Intravenous Immunoglobulin Solutions During Freeze-Thawing and Agitation Stresses
Fulltext Access 6 Pages 2018
Total synthesis of akuammiline alkaloid (+)-strictamine
Fulltext Access 6 Pages 2018
Characterization of a helminthosporic acid analog that is a selective agonist of gibberellin receptor
Fulltext Access 6 Pages 2018
Exploration of diphenylalkyloxadiazoles as novel cardiac myosin activator
Fulltext Access 6 Pages 2018
Lipid accumulation inhibitory activities of novel isoxazole-based chenodeoxycholic acids: Design, synthesis and preliminary mechanism study
Fulltext Access 6 Pages 2018
Activatable fluorescent probes in fluorescence-guided surgery: Practical considerations
Fulltext Access 6 Pages 2018
Synthesis, spectroscopic studies and biological evaluation of acridine derivatives: The role of aggregation on the photodynamic efficiency
Fulltext Access 6 Pages 2018
Novel carbamate-linked quaternary ammonium lipids containing unsaturated hydrophobic chains for gene delivery
Fulltext Access 6 Pages 2018
Ionic liquid-enabled synthesis, cholinesterase inhibitory activity, and molecular docking study of highly functionalized tetrasubstituted pyrrolidines
Fulltext Access 6 Pages 2018
Taurine as a green bio-organic catalyst for the preparation of bio-active barbituric and thiobarbituric acid derivatives in water media
Fulltext Access 6 Pages 2018
Zonal distribution of neutral aroma components in flue-cured tobacco leaves
Fulltext Access 6 Pages 2018
Facile construction of trifluoromethyl-azirines via one-pot metal-free Neber reaction
Fulltext Access 6 Pages 2018
Continuous, on-demand generation and separation of diphenylphosphoryl azide
Fulltext Access 6 Pages 2018
Transition metal-free cross-coupling of furan ring with haloacetylenes
Fulltext Access 6 Pages 2018
Identification and characterization of the druggable kinase targets of olmesartan and its analogues from a systematic kinase-chemical interaction profile in atherosclerosis
Fulltext Access 6 Pages 2018
Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats
Fulltext Access 7 Pages 2018
Unprotected primary sulfonamide group facilitates ring-forming cascade en route to polycyclic [1,4]oxazepine-based carbonic anhydrase inhibitors
Fulltext Access 7 Pages 2018
Development of a single-jet electrospray method for producing quercetin-loaded poly (lactic-co-glycolic acid) microspheres with prolonged-release patterns
Fulltext Access 7 Pages 2018
A specific two-pulse release of rivastigmine using a modified time-controlled delivery system: A proof of concept case study
Fulltext Access 7 Pages 2018
Selection of phospholipids to design liposome preparations with high skin penetration-enhancing effects
Fulltext Access 7 Pages 2018
Design, synthesis and antimycobacterial activity of 3,5-dinitrobenzamide derivatives containing fused ring moieties
Fulltext Access 7 Pages 2018
Iodine-promoted three-component reaction for the synthesis of spirooxindoles
Fulltext Access 7 Pages 2018
A cell surface clicked navigation system to direct specific bone targeting
Fulltext Access 7 Pages 2018
The impact of process parameters on carrier free paracetamol nanosuspension prepared using different stabilizers by antisolvent precipitation method
Fulltext Access 7 Pages 2018
Design, synthesis and biological evaluation of new carbazole derivatives as anti-cancer and anti-migratory agents
Fulltext Access 7 Pages 2018
Development of a microbioreactor for glycoconjugate synthesis
Fulltext Access 7 Pages 2018
Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery
Fulltext Access 7 Pages 2018
Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs
Fulltext Access 7 Pages 2018
Facilely accessible quinoline derivatives as potent antibacterial agents
Fulltext Access 7 Pages 2018
Structure-based design of free fatty acid receptor 1 agonists bearing non-biphenyl scaffold
Fulltext Access 7 Pages 2018
Evaluation of 4-phenylamino-substituted naphthalene-1,2-diones as tubulin polymerization inhibitors
Fulltext Access 7 Pages 2018
Identification of anti-inflammatory active peptide from black soybean treated by high hydrostatic pressure after germination
Fulltext Access 7 Pages 2018
Structure-based optimization of free fatty acid receptor 1 agonists bearing thiazole scaffold
Fulltext Access 7 Pages 2018
Effect of alkyl chain on cellular uptake and antitumor activity of hydroxycamptothecin nanoparticles based on amphiphilic linear molecules
Fulltext Access 7 Pages 2018
Synthesis of phenanthroimidazole-based four coordinate organoboron compounds
Fulltext Access 7 Pages 2018
Relict plastidic metabolic process as a potential therapeutic target
Fulltext Access 7 Pages 2018
Triple domino reaction for the synthesis of pyrazole/indoline linked chromenes
Fulltext Access 7 Pages 2018
Palladium-catalyzed allylation and deacylative allylation of 3-acetyl-2-oxindoles with allylic alcohols
Fulltext Access 7 Pages 2018
Cembranoids from Eunicea sp. enhance insulin-producing cells proliferation
Fulltext Access 7 Pages 2018
A dichotomy in the enantioselective oxidation of aryl benzyl sulfides: A combined experimental and computational work
Fulltext Access 7 Pages 2018
Comparing of endocyclic and exocyclic cleavage reactions using mycothiol synthesis as an example
Fulltext Access 7 Pages 2018
Novel fluorescent N,O-chelated fluorine-boron benzamide complexes containing thiadiazoles: Synthesis and fluorescence characteristics
Fulltext Access 7 Pages 2018
Organic superbase-induced chemiluminescent decomposition of a hydroxyaryl-substituted dioxetane: Unique effect of a bifunctional guanidine base on the chemiluminescence profile of a bicyclic dioxetane bearing a 4-(benzoxazol-2-yl)-3,5-dihydroxyphenyl moie
Fulltext Access 7 Pages 2018
A green, isocyanide-based three-component reaction approach for the synthesis of multisubstituted ureas and thioureas
Fulltext Access 7 Pages 2018
The synthesis, antifungal and apoptotic effects of triazole-oxadiazoles against Candida species
Fulltext Access 7 Pages 2018
Branching tryptamines as a tool to tune their antiproliferative activity
Fulltext Access 7 Pages 2018
Design, synthesis and antimicrobial evaluation of propylene-tethered ciprofloxacin-isatin hybrids
Fulltext Access 7 Pages 2018
Curcumin inspired 2-chloro/phenoxy quinoline analogues: Synthesis and biological evaluation as potential anticancer agents
Fulltext Access 7 Pages 2018
Haspin: a promising target for the design of inhibitors as potent anticancer drugs
Fulltext Access 7 Pages 2018
Circadian variations in the pharmacokinetics of capecitabine and its metabolites in rats
Fulltext Access 7 Pages 2018
The influence and manipulation of acid/base properties in drug discovery
Fulltext Access 7 Pages 2018
Gallium-68 labeled Ubiquicidin derived octapeptide as a potential infection imaging agent
Fulltext Access 7 Pages 2018
Synthetic strigolactone analogues reveal anti-cancer activities on hepatocellular carcinoma cells
Fulltext Access 7 Pages 2018
Design and characterization of bivalent compounds as potential neuroprotectants for Alzheimer's disease: Impact of the spacer on biological activity
Fulltext Access 7 Pages 2018
Synthesis and anti-proliferative activity of allogibberic acid derivatives containing 1,2,3-triazole pharmacophore
Fulltext Access 7 Pages 2018
Design and validation of a simple device for insufflation of dry powders in a mice model
Fulltext Access 7 Pages 2018
Intestinal permeability determinants of norfloxacin in Ussing chamber model
Fulltext Access 7 Pages 2018
Topically used corticosteroids: What is the big picture of drug product degradation?
Fulltext Access 7 Pages 2018
New arguments for beneficial effects of alpha-lipoic acid on the cardiovascular system in the course of type 2 diabetes
Fulltext Access 7 Pages 2018
Microemulsion containing triamcinolone acetonide for buccal administration
Fulltext Access 7 Pages 2018
Particle sizing of pharmaceutical aerosols via direct imaging of particle settling velocities
Fulltext Access 7 Pages 2018
Correlation between glucuronidation and covalent adducts formation with proteins of nonsteroidal anti-inflammatory drugs
Fulltext Access 7 Pages 2018
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