Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10142969 | Microvascular Research | 2019 | 16 Pages |
Abstract
Results of our experiments suggest that mastoparan-7 significantly induces contraction of vascular smooth muscle cells not only for controls but in the presence of ischemia and reperfusion too. Potential therapeutic applications of the observed reactions are important. They may include regenerative processes within the nervous system, studies on the improvement of blood flow within the microcirculation, or antimicrobial activity. Modulation of the G protein-phospholipase C response may also be an interesting point of action of future drugs modifying the response to stimulation during ischemia in particular, such activities could take place during the transport of organs for transplantation.
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Authors
Elżbieta GrzeÅk, Nasser Darwish, Wioleta Stolarek, MichaÅ WiciÅski, Bartosz Malinowski, Igor BurdziÅski, Grzegorz GrzeÅk,