Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10148552 | Diabetes & Metabolic Syndrome: Clinical Research & Reviews | 2019 | 28 Pages |
Abstract
Wound healing in diabetes is frequently impaired and its treatment remains a challenge. The ability of topical application of cerium (Ce) dioxide nanoparticles (CNPs) to accelerate wound healing in an animal model provides a rationale to develop this technology for use in humans affected by traumatic injury, diabetes and burns. We first described a case report of successful topical treatment of neuropathic diabetic foot ulcers with novel gel containing CNPs. The CNPs has bacteriostatic activity, anti-inflammatory properties and can penetrated into the wound tissue and reduced oxidative damage therefore protect regenerative tissue, suggesting a therapeutic potential for topical treatment of diabetic foot ulcers.
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Authors
Nazarii Kobyliak, Ludovico Abenavoli, Liudmyla Kononenko, Dmytro Kyriienko, Mykola Spivak,