Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10148695 | Microbial Pathogenesis | 2018 | 11 Pages |
Abstract
The present investigates the antiquorum sensing and biofilm inhibitory potential of 5 - hydroxymethylfurfural against Chromobacterium violaceum, Streptococcus pyogenes, Streptococcus mutans, Staphylococcus aureus and Staphylococcus epidermidis. 5HMF inhibits the quorum sensing mediated violacein pigment production by 87% at 100â¯Î¼g/ml concentration. A 100â¯Î¼g/ml concentration of the compound inhibits S. mutans and S. epidermidis biofilm formation by 86% and 79% whereas for S. pyogenes and S. aureus 125â¯Î¼g/ml concentration inhibits biofilm formation by 83% and 82%. The Confocal images clearly indicate that 5HMF as a promising antibiofilm agent.
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Authors
Karuppiah Vijayakumar, Thiruganasambandam Ramanathan,