Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10156716 | Biochimica et Biophysica Acta (BBA) - Biomembranes | 2018 | 8 Pages |
Abstract
There is a diverse class of peripheral membrane-binding proteins that specifically bind phosphatidylserine (PS), a lipid that signals apoptosis or cell fusion depending on the membrane context of its presentation. PS-receptors are specialized for particular PS-presenting pathways, indicating that they might be sensitive to the membrane context. In this review, we describe a combination of thermodynamic, structural, and computational techniques that can be used to investigate the mechanisms underlying this sensitivity. As an example, we focus on three PS-receptors of the T-cell Immunoglobulin and Mucin containing (TIM) protein family, which we have previously shown to differ in their sensitivity to PS surface density.
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Authors
Daniel Kerr, Gregory T. Tietjen, Zhiliang Gong, Emad Tajkhorshid, Erin J. Adams, Ka Yee C. Lee,