Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10156898 | International Journal of Biological Macromolecules | 2018 | 11 Pages |
Abstract
Amphiphilic ionic complexes of hyaluronic acid and alkyltrimethylphosphonium soaps with alkyl chains containing even numbers of carbons from 12 to 22 have been produced. The complexes have a nearly stoichiometric composition, are non-water soluble, and are stable to heat up to temperatures above 200â¯Â°C. These complexes are amphiphilic and able to adopt a biphasic structure with the paraffinic and polysaccharide phases ordered arranged with a periodicity ranging between 3 and 5â¯nm depending on n. The paraffinic phase in complexes with nâ¯â¥â¯18 was crystallized and showed melting at temperatures between 58 and 70â¯Â°C depending on the n value. The complexes decomposed upon incubation in water under physiological conditions, and undergone extensive biodegradation by the action of hyaluronidases. Biocide assays carried out in both solid and liquid media demonstrated a high antimicrobial activity of the complexes against Gram-positive S. aureus but moderate against Gram-negative E. coli and C. albicans fungi.
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Authors
Ana Gamarra, Eva Forés, Jordi Morató, Sebastián Muñoz-Guerra,