| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10158165 | Acta Pharmaceutica Sinica B | 2018 | 14 Pages |
Abstract
Human carboxylesterases (CES) play crucial roles in both endo- and xenobiotic metabolism, which arouse great interest in the discovery of potent CES modulators to regulate endobiotic metabolism or to improve the outcomes of ester drugs. This review covers the structural and catalytic features of human CES, tissue distributions, biological functions and substrate specificities of two predominant human CES, as well as the significance and recent progress on the discovery of human CES modulators.324
Keywords
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Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Dandan Wang, Liwei Zou, Qiang Jin, Jie Hou, Guangbo Ge, Ling Yang,